Donepezil
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Donepezil
All You Need To Know About Aricept
What is an Aricept?
Donepezil is the generic name for Aricept. A cholinesterase inhibitor called donepezil is used to treat dementia as well as other mild, moderate, or severe Alzheimer's symptoms. It functions by stopping the acetylcholine in the brain tissue from degrading. Because its breakdown in the brain tissue is prevented, the amount of acetylcholine rises. Enhancing brain cell connectivity, it enhances mental performance and cognition. Alzheimer's disease cannot be cured, although the drug donepezil can slow the decline in mental capacities including thinking, remembering, etc.
What are Aricept Uses?
Aricept is primarily used to treat Alzheimer's disease by enhancing cognition and behaviour. It is advised as a strategy to treat Alzheimer's disease, whether it be mild, moderate, or even severe. To see the advantages, periodic screenings of the patient taking Aricept are recommended. The ingestion should end if there is no discernible effectiveness.
According to medical research, discontinuing Aricept therapy for dementia patients causes a sizable decline in the patient's cognitive function. Other medical diseases like Lewy Body Dementia, Vascular Dementia, Traumatic Brain Injury, and Parkinson's Disease-Related Dementia may also benefit from Aricept's ability to lessen their symptoms.
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Aricept is a very important medicine for Alzheimer’s Treatment in California. One can easily get it prescribed, Fill up the evaluation form
Donepezil Hydrochloride
Brand Name: Aricept
Generic Available
Dosage Forms:
Tablets, 5 mg, 10 mg, and 23 mg.
Tablets, orally-disintegrating (Aricept ODT): 5 mg and 10 mg.
FDA Indications/Dosages:
For the treatment of mild, moderate, and severe dementia of the Alzheimer’s type: Begin with a dose of 5 mg at bedtime. Dosage may be increased after an initial period of 4 to 6 weeks to a daily dose of 10 mg given at bedtime. A dose of 23 mg once daily can be given after patients have been on a dose of 10 mg once daily for at least 3 months. As may be expected, cholinergic side effects are greater with the higher dose.
Pharmacology/Pharmacokinetics: Alzheimer’s disease is characterized by early changes in cholinergic pathways in the CNS, including a deficiency of cortical acetylcholine. Donepezil hydrochloride is a reversible acetylcholine inhibitor that works centrally to increase the amount of acetylcholine available at cholinergic synapses. Peak plasma levels are reached in 3-4 hours with an elimination half-life of 70 hours. About 96% is bound to plasma proteins. Metabolism occurs via CYP 450 isoenzymes 2D6 and 3A4.
Drug Interactions: The clinical effects on CYP2D6 and 3A4 not known. In vitro there are minimal effects on the metabolism of terfenadine and cisapride. The metabolism of Aricept may be increased by phenytoin, carbamazepine, phenobarbital, rifampin, or dexamethasone, or decreased by ketoconazole, or quinidine.
Contraindications/Precautions: Contraindicated in patients with known hypersensitivity to donepezil or piperidine derivatives. It may be beneficial to discontinue usage prior to known anesthesia. May cause vagotonic effects on the heart therefore use caution in patients with sick sinus syndrome. May increase gastric acid secretion therefore use caution in patients prone to ulcers or GI bleeding. Use with caution in patients with asthma or obstructive pulmonary disease. Pregnancy Category C.
Adverse Effects: The most common adverse effects are nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue, and anorexia. Rare but potentially serious adverse effects include rhabdomyolysis, QTc prolongation, Stevens Johnson syndrome, and toxic epidermal necrolysis.
Patient Consultation:
May be taken with or without food.
Take in the evening, just prior to retiring.
Store in a cool, dry place away from sunlight and children.
Contact a physician if the above side effects are severe or persistent.
If a dose is missed, skip it and return to normal dosing schedule.
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A MINUTE OF YOUR DAY – Protect Yourself
I hope that title got your attention. You need to protect yourself with SUNSCREEN and hats, and you need to protect your loved one.
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