#basement membrane

[lantsandlaminin]

Funded PhD position Available - Laminins, Superresolution microscopy and Junctional Epidermolysis Bullosa

Very exciting news – Fight For Sight and DEBRA are supporting a PhD studentship with my group and we are now accepting applications. From Gene Editing to Therapeutics: Building Human Corneal Models of Inherited Fragility Disorder Junctional Epidermolysis Bullosa In this project you will work at the frontier of cell engineering and high resolution imaging to understand how inherited mutations…

Funded PhD position Available - Laminins, Superresolution microscopy and Junctional Epidermolysis Bullosa

[lantsandlaminin]

New Paper Published - Understanding Laminin N Terminus Alpha 31's Role in Corneal Healing

I’m very pleased to tell you about our latest paper published this week in PLOS One. Its been a long time coming, the manuscript co-first authored by two of the lab’s former PhD students Dr Lee Troughton, now at Loyola University and Dr Valentina Iorio now managing the teaching labs at University of Liverpool. Indeed, most of the team through the years contributed to this work with former PhD…

New Paper Published - Understanding Laminin N Terminus Alpha 31's Role in Corneal Healing

[lantsandlaminin]

They Grow Up so Fast - Congratulations to Dr Fawziah Asiri

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[bpod-bpod]

Organ Building Basis

Cells and tissue are supported by extracellular matrix known as the basement membrane. Study of fruit fly egg chambers (pictured) as a model system reveals that members of the ADAMTS enzyme family control the basement membrane's composition and properties that underlie organ shape

Read the published research article here

Image from work by Uwe Töpfer and colleagues

Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada; School of Science, Technische Universität Dresden, Dresden, Germany

Image contributed and copyright held by Uwe Töpfer

Research published in Cell Reports, July 2024

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[lantsandlaminin]

New paper published - First ever LaNt in vivo studies!

New paper published - Describing laminin N terminus alpha31 in a transgenic mouse model. The first in vivo experiments into this protein. The results are striking and change the way we think about laminin regulation. #ECM #basementmembrane #laminin

This is big one. I am extremely pleased to (finally) be able to announce the publication of our most recent paper “Laminin N-terminus a31 expression during development is lethal and causes widespread tissue-specific defects in a transgenic mouse model” in FASEB Journal. Read the paper here [link]. Read the lay summary “LaNt wars” here [link]. It has been a long journey to get this one over the…

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[lantsandlaminin]

New paper out - Laminin polymerization and inherited disease: lessons from genetics

New paper out - Laminin polymerization and inherited disease: lessons from genetics #laminin #MDC1A #pierson #JEB #basement membrane

Link to paper (free accesss) Regular readers of this blog will know that we love laminins here. The most interesting* and important protein family! One of the many reasons that we can confidently say that laminins are important is that if they don’t function properly the effects are devastating leading to diseases including muscular dystrophy (MDC1A), kidney and eye defects (Pierson syndrome)…

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[lantsandlaminin]

2 New papers out - Comprehensive reviews of conjunctival ECM and replacement strategies

2 New papers out – Comprehensive reviews of conjunctival ECM and replacement strategies

Two linked review articles “The conjunctival extracellular matrix, related disorders and development of substrates for conjunctival restoration” and “Biological tissues and components, and synthetic substrates for conjunctival cell transplantation” were published in The Ocular Surface recently. You can access the first paper for free via this link for the next 50 days, and the second one as…

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[lantsandlaminin]

They grow up so fast - ASMB Nashville

They grow up so fast – ASMB Nashville

This week Lee and I are in Nashville for the biannual American Society of Matrix Biology Basement Membrane workshop. Cue the obligatory blog post about the team presenting their work…

As a lab, we go to a variety of different meetings. Some focus on a tissue (eye or skin), others on cancers , and others still broadly focused on cell or matrix biology. In each of these we learn lots of stuff but…

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