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On the balance of knowledge - Immunology Research
Nature Reviews Immunology, Published online: 05 February 2026; doi:10.1038/s41577-026-01276-4 Ruslan Medzhitov shares his thoughts on the balance between generating data and developing theories in immunology, with a focus on exploring the rules that govern complex systems. Read more about this post… Credits: Source Disclaimer
Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy - New Study
Manufacturing of CRISPR-edited primary mouse CAR T cells for cancer immunotherapy Summary CRISPR-Cas9 technology can enhance CAR T-cell immunotherapy by improving T-cell function and targeting specificity. This study focuses on a streamlined manufacturing process for generating CRISPR-edited, primary mouse CAR T cells. The process involves electroporation of Cas9 ribonucleoprotein (RNP)…
meet the researchers trying to turn water bears into neuroscience models
There’s no two ways about it: tardigrades are badblock. These eight-legged, microscopic water-dwellers have survived the vacuum of space, extreme dehydration, and temperatures ranging from near absolute zero to above boiling point. In 2021, researchers fired frozen tardigrades from a gun onto a target several metres away, to simulate a meteorite impact, and showed that they lived to tell the…
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A ‘killswitch’ peptide solidifies protein droplets in living cells
RESEARCH BRIEFINGS 18 June 2025 Human cells contain dozens of different types of proteinaceous droplets called biomolecular condensates. A newly developed tool provides insights into the behaviour of biomolecules in condensates and into the functions of condensates in living cells. Source link
Mengapa begitu sulit untuk menulis ulang genom?
Ketika Patrick Yizhi Cai merefleksikan keadaan genomika sintetis, dia mengingat Kontes DNA Besar. Diluncurkan pada tahun 2004, kompetisi ini menantang para ahli biologi sintetis untuk merancang urutan DNA 40.000 pasangan basa yang baru dan fungsional yang akan diproduksi secara gratis oleh sponsor kontes, yaitu perusahaan sintesis DNA Amerika Serikat, Blue Heron Biotech (sekarang Eurofins…
Sensing methods of Dielectrophories from Bulky Instruments to Lab-on-a-chip
Sensing methods of Dielectrophories from Bulky Instruments to Lab-on-a-chip
Recently, the sensing methods for dielectrophoresis (DEP) have been changed from bulky instruments to lab-on-a-chip. Lab-on-a-chip based the dielectrophoresis phenomenon holds the promise to give biology the advantage of miniaturization for carrying out complex experiments. However, until now, there is an unmet need for lab-on-a-chip to effectively deal with the biological systems at the cell…
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90s LAB PROBLEMS!
Funny but one can realize how much biological techniques and tools have improved the last decades...
