Although the chemical imbalance model remains the dominant cultural story of depression in the United States (France, Lysaker, & Robinson, 2007), its validity has been publicly questioned with increasing frequency in recent years (e.g., Angell, 2011a, 2011b; Begley, 2010; Spiegel, 2012; Stahl, 2012). Scientists have long understood the “low serotonin” explanation of depression to be unsubstantiated (Kendler & Schaffner, 2011; Kirsch, 2010; Lacasse & Leo, 2005), and psychiatry is currently attempting to distance itself from this pseudoscientific notion. Prominent biomedical model proponents now use adjectives like “antiquated” (Insel, 2011) and “outmoded” (Coyle, cited in Spiegel, 2012) to describe the chemical imbalance story, thereby creating the misleading impression that this notion has only recently been exposed as mistaken. Pies (2011) proclaimed that the chemical imbalance theory is an “urban legend” that was never taken seriously by thoughtful psychiatrists. “In the past 30 years,” he asserts, “I don't believe I have ever heard a knowledgeable, well-trained psychiatrist make such a preposterous claim, except perhaps to mock it.” This declaration might come as a surprise to former APA president Steven Sharfstein who explicitly defended the validity of the chemical imbalance theory on NBC's Today Show (Bell, 2005b) in the wake of actor Tom Cruise's infamous remarks criticizing psychiatry (Bell, 2005a). Patients with mental disorders might also be surprised to learn that some doctors use the chemical imbalance story simply as a convenient metaphor for facilitating drug treatment and/or attempting to reduce stigma. Until recently, the American public had little reason to doubt the veracity of chemical imbalance claims promoted by the popular media, health websites, patient advocacy groups, governmental agencies, and other reputable medical authorities. Given recent high-profile revelations about the limitations of the chemical imbalance story, biomedical model advocates may face increasing pressure to disseminate accurate information about mental disorder rather than persist in the promotion of an unfounded but politically and economically useful scientific caricature.
–Brett J. Deacon, “The biomedical model of mental disorder: A critical analysis of its validity, utility, and effects on psychotherapy research.” Clinical Psychology Review 33 (2013), 846–861. http://dx.doi.org/10.1016/j.cpr.2012.09.007