#cold thermogenesis

[kramlabs]

I was wrong about this too*

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*but cold thermogenesis and BAT conversion are real, but the effects are measurable starting at any temperature below 98.1.

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Update:

From comments:

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: back in the day:

[kramlabs]

[kramlabs]

More better mitochondria

High animal-low plant, seasonal keto, walking/rucking, lift weights, sprint/HIIT, get cold, get hot, get sun, avoid blue light at night, avoid PUFA’s, especially linoleic//omega-6’s

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[kramlabs]

[kramlabs]

[kramlabs]

https://www.nature.com/nature/journal/v404/n6778/full/404652a0.html

[kramlabs]

“The mitochondria in a eukaryotic cell utilize fuels to produce energy in the form of adenosine triphosphate (ATP). This process involves storing energy as a proton gradient, also known as the proton motive force (PMF), across the mitochondrial inner membrane. This energy is used to synthesize ATP when the protons flow across the membrane (down their concentration gradient) through the ATP synthase enzyme; this is known as chemiosmosis.

In endotherms, body heat is maintained by signaling the mitochondria to allow protons to run back along the gradient without producing ATP (proton leak). This can occur since an alternative return route for the protons exists through an uncoupling protein in the inner membrane. This protein, known as uncoupling protein 1 (thermogenin), facilitates the return of the protons after they have been actively pumped out of the mitochondria by the electron transport chain. This alternative route for protons uncouples oxidative phosphorylation and the energy in the PMF is instead released as heat.

To some degree, all cells of endotherms give off heat, especially when body temperature is below a regulatory threshold. However, brown adipose tissue is highly specialized for this non-shivering thermogenesis. First, each cell has a higher number of mitochondria compared to more typical cells. Second, these mitochondria have a higher-than-normal concentration of thermogenin in the inner membrane.”

https://en.wikipedia.org/wiki/Brown_adipose_tissue

https://en.wikipedia.org/wiki/Thermogenesis

“Cold exposure increases circulating irisin.[42] Irisin improves insulin sensitivity, increases bone quality and quantity, is involved in the building of lean muscle mass, and helps reduce obesity by converting white fat to brown fat,[44] providing many of the same benefits of exercise.[45] Healthy centenarians are characterized by increased serum irisin levels, whereas levels of this hormone were found to be significantly lower in young patients with myocardial infarction. These findings may prompt further research into the role played by irisin not only in vascular disorders but also in life span modulation.[46]Cold exposure increases SIRT1 phosphorylation/activity in both skeletal muscle and BAT, increasing thermogenesis and insulin sensitivity.[47] Elevated SIRT1 levels in people are associated with increased human longevity.[48] SIRT1 (and the other sirtuins) have many metabolic effects, but an important one for improving health and longevity is the fact that SIRT1 increases insulin sensitivity and glucose control in skeletal muscles,[49] triggers the browning of white fat[50] and increases BAT activity.[51]“

[kramlabs]

Jack Kruse on Cold thermogenesis and carbs

Two Swim-Related Deaths this Weekend at Ironman 70.3 Mossel Bay - Triathlon Magazine Canada

The community mourns two deaths that occurred during the swim portion of the Mossel Bay 70.3.

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