#g-protein

[medschooltutors]

The Med Student's Guide to Receptors

If you are looking for a receptors cheat sheet--alpha receptors, beta receptors, M receptors, dopamine receptors and more--you have come to the right place.

Whoever said that it’s better to give than receive clearly never met a #GProtein. 

[reportsandmarkets]

G-protein Coupled Receptor Market Report 2017

G-protein Coupled Receptor Market Report 2017

About: G-protein Coupled Receptor Request For PDF of Premium Research Report WithTOC@ https://www.reportsandmarkets.com/sample-request/asia-pacific-g-protein-coupled-receptor-market-report-2017-1622938 In this report, the Asia-Pacific G-protein Coupled Receptor market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between…

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[reportsandmarkets]

G-Protein Coupled Receptor Market by Top Manufacturers with Production, Price, Revenue (value) and Market Share to 2017

G-Protein Coupled Receptor Market by Top Manufacturers with Production, Price, Revenue (value) and Market Share to 2017

Request For Description @https://www.reportsandmarkets.com/reports/global-g-protein-coupled-receptor-industry-market-research-2017-1585815 In this report, we analyze the G-Protein Coupled Receptor industry from two aspects. One part is about its production and the other part is about its consumption. In terms of its production, we analyze the production, revenue, gross margin of its main…

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[houseofmind]

Histamine 

....And the transmitter series is back in business. If you've been following from the start, you know what I'm talking about ;) If you're new, welcome!

Here is a list of neurotransmitters that have been covered so far: 

Dopamine

Serotonin

Norepinephrine

Glutamate

GABA

Acetylcholine

Histamine acts as a modulatory neurotransmitter. As such, it acts through G-protein coupled receptors to fine-tune excitatory and inhibitory neurotransmitters.  Histamine is involved in a number of biological processes, including immune and inflammatory responses, maintenance of wakefulness, feeding and energy balance and regulating physiological function in the gut. 

Histamine is produced in the brain by mast cells and neurons for regulated release. In the adult mammalian brain, histamine is produced exclusively in the tuberomammillary nucleus (TMN) of the hypothalamus, which sends fibre projections to all  major parts of the brain. Histamine released from TMN neurons activate 3 G-protein coupled receptors. These are:

H1Rs and H2Rs- located in neuronal and glial cells, expressed postsynaptically and have important roles in the cerebral cortex, striatum, hypothalamus, and hippocampus H3Rs- exclusively expressed in neurons; can act as both auto receptors in histaminergic neurons and heteroreceptors in nonhistaminergic neurons which regulate release of other neurotransmitters

Studies in humans and animal models of psychiatric disorders suggest a role for histamine dysfunction in the following diseases:

Narcolepsy and sleep disorders Cognitive dysfunction and Alzheimer's disease Motor disorders such as Parkinson's disease and Gilles de la Tourette syndrome Schizophrenia Addictive behaviors Multiple sclerosis 

Sources: 

Panula and Nuutinen (2013). The histaminergic network in the brain: basic organization and role in disease. Nature Reviews Neuroscience 14: 472-487. 

[onedirectionfingerlickinggood]

Did Niall date Ellie Goulding? I just saw it on Daily Mail, and I am so confused! x

as far as I'm concerned it was all rumors and didn't date. x

[ilovethebrain-blog]

sigh

I find myself waking up with a heavy heart this morning, mostly because I know that today I need to memorize almost the entire PSYCO 478 (Psychopharmacology) course in a single day. You see, the class I'm taking right now, PSYCI 511 (Introduction to Psychiatry) features two lectures by the fabled Dr. S. Kar, the main reason I dropped NEURO 410. I went to that class on the first day, observed his very first lecture on the nature of K+ channels, distinctly remember myself muttering, "Eff this..." and getting up early to leave. I find myself face-to-face with this professor again, but now he's rattling on about neurotransmitter and neuromodulator profiles, going through each NT in about 15 minutes or less. Mind you, in PSYCO 478, an NT system would take us at least a week and a half to finish, so he's zipping through this stuff pretty fast. Just to give you an indication of what this guy wants me to memorize, let me introduce you to one of the seven circles of hell: Try memorizing ~50 pharmacological agents with names like hexahydrosiladifenidol (Ach M3 selective antagonist) or heaven forbid the three metabotropic glutamate receptor identifiers: 2,5-dihydroxyphenylglycine (Class I mGluR), 2-(2,3-dicarboxycycloepropyl)-glycine (Class II mGluR) and 2-amino-4-phosphonobutyrate (Class III mGluR). Their short forms don't even match their names (DHPG, DCG-IV, and L-AP4)!! You can understand why I find myself dragging my feet to Second Cup today to study this garbage. I have to deal with memorizing synthesis/release, distribution, receptor profile and functions of 8 major NTs, followed by a few neuromodulators to boot. My class is starting to freak out - some girl e-mailed the whole class requesting that we form a study group to go over the material because there's so much and she doesn't know where to start. I'm just glad I've done this kind of thing before in PSYCO 478, but it's still causing my brain to hurt.

***

Anyways, I posted a great joke I made up in class the other day on Facebook, but I think it probably eludes the majority of individuals (you'd have to be 1. male 2. heavily into neuroscience to get it). That being said I'll explain it: Question: What do Snake Eyes, Storm Shadow, and the majority of metabotropic glutamate receptors have in common? The first component: Snake Eyes and Storm Shadow are characters from the timeless classic series G.I. Joe. The second component: G-proteins are specific second-messenger signalling pathways that are often used to jump-start a physiological reaction (according to Dr. Kar, 40% of clinical drugs use G-protein pathways). That being said, there are three types of G-proteins: Gq/G11, Gs, and Gi/Go. The majority of mGluRs operate via Gi/Go. Thus: Answer: They are all Gi/Gos!!! Brilliant huh? I know, I am so proud of myself; my claim to fame.