#gutbrainaxis

[neurosciencenews]

Researchers discover crucial link between brain and gut stem cells

The insulin-like growth factor II gene plays a critical role in adult stem cell maintenance of both the intestine and the brain. Findings suggest IGF-2 is essential for multiple stem cell types, including those implicated in cognitive function and renewing the lining of the small intestine.

Read the full article here: https://neurosciencenews.com/gut-brain-stem-cells-11087/

In the study, the researchers removed the gene from adult mice either rapidly over five days or more slowly over 15 days. In the intestine, the fast deletion of the gene led to a rapid loss of fast-cycling stem cells that replenish the gut lining, leading to dramatic weight loss and death within a week. A slower deletion of the gene allowed the mice to survive due to the recruitment of a second, and more inactive, population of gut stem cells, whose existence has been debated. Additionally, the study revealed that half of the stem cells in two regions of the brain that house neural stem cells were lost, causing deficits in learning and memory, increased anxiety and a loss of the sense of smell.

(Their findings show that the insulin-like growth factor II gene is essential for multiple types of adult stem cells that are critical for cognitive function and renewing the lining of small intestine in adults. The image is adapted from the Rutgers University news release. )

“Insulin-like Growth Factor II: An Essential Adult Stem Cell Niche Constituent in Brain and Intestine” Levison et al. Stem Cell Reports. Published online April 15, 2019 doi:10.1016/j.stemcr.2019.02.011

[naturalwellnessjourney]

*******GLYPHOSATE******* By 2025, half the children born in the United States will be diagnosed with autism, says Dr. Stephanie Seneff, a senior research scientist at the MIT Computer Science and Artificial Intelligence Laboratory. “Is there a toxic substance that is currently in our environment on the rise in step with increasing rates of autism that could explain this?” She asks in a 2013 presentation sponsored by Wellesley League of Women Voters. “The answer is yes, I’m quite sure that I’m right, and the answer is glyphosate.” -Dr Stephanie Seneff . . . https://www.medicaldaily.com/autism-rates-increase-2025-glyphosate-herbicide-may-be-responsible-future-half-316388 . . . . . . . #GLYPHOSATE #AUTISM #HEAVYMETALTOXICITY #ENVIRONMENT #ASD #SUPPORTASD #autismawarenessmonth #autismsupport #detox #toxicoverload #foodallergies #glutenintolerance #gutbrainaxis #gutbrainconnection #guthealth https://www.instagram.com/p/BwGVqTaH0bs/?utm_source=ig_tumblr_share&igshid=rck3qk7qf599

[starhospitalseo]

Gut–Brain Link May Explain ALS & Dementia Risk

Discover how the gut–brain link influences ALS and dementia risk. Neurologist insights on causes, prevention, and brain health. Read more.

New Gut–Brain Link May Explain ALS and Dementia Risk, Says Neurologist

A New Understanding of the Gut–Brain Axis

By Dr. Neeharika L. Mathukumalli, Senior Consultant Neurologist and specialist in autoimmune neurological diseases, STAR Hospitals, Banjara Hills

Recent research has strengthened the growing evidence that the gut–brain axis plays a critical role in the development of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD), according to Dr. Neeharika L Mathukumalli, Sr. Consultant in Neurology and specialist in autoimmune neurological diseases at STAR Hospital, Banjara Hills.

Referring to a study published in Cell Reports, Dr. Neeharika explains that certain gut bacteria may produce inflammatory forms of glycogen, a type of sugar, which can trigger immune-mediated damage to brain cells. “This study provides an important biological link between gut microbiota and neuroinflammation, which has been a missing piece in understanding diseases like ALS and FTD,” she said.

How These Diseases Affect the Brain

ALS is a progressive neurological disorder affecting motor neurons, leading to muscle weakness and eventual paralysis, while FTD primarily impacts the frontal and temporal lobes, resulting in behavioral and language disturbances. In most patients, the exact cause of these conditions remains unclear.

Link Between Genetics and Environment

“The findings are particularly relevant because they help explain why some individuals with genetic predisposition, such as C9orf72 mutations, develop these diseases while others do not,” Dr. Neeharika noted. “It suggests that environmental factors, especially gut microbiome alterations, may influence disease onset and progression.”

According to the study, nearly 70% of patients with ALS and FTD were found to have elevated levels of harmful bacterial sugars, compared to about one-third of individuals without these conditions. “This difference is clinically significant and points toward a potential modifiable pathway,” she added.

Rising Disease Burden

Globally, ALS affects approximately 2–3 individuals per 100,000 population, and FTD accounts for around 10–20% of early-onset dementia cases. Notably, nearly 90% of ALS cases are sporadic, without a clear inherited cause, further highlighting the importance of identifying non-genetic contributors.

Why the Gut Matters

Dr. Neeharika emphasized that the human gut microbiome plays a major role in regulating the immune system. “The gastrointestinal system hosts trillions of microorganisms and is closely linked to immune function. Any imbalance in this system can have far-reaching effects, including on brain health,” she explained.

Implications for Future Treatment

From a treatment perspective, the findings open up new possibilities. “Targeting the gut microbiome—either by reducing harmful bacterial metabolites or modifying microbial composition—could emerge as a future therapeutic strategy,” she said. Early experimental data suggest that reducing these harmful sugars may improve neurological outcomes.

However, she cautioned that more clinical trials are needed before such approaches become part of routine care. “While the findings are promising, they should be seen as an early step toward understanding disease mechanisms rather than an immediate solution,” she noted.

Importance of Early Awareness

Dr. Neeharika also highlighted the importance of early awareness. “Neurodegenerative diseases often have a long preclinical phase. Identifying early biological triggers, such as gut-related inflammatory signals, may help in early diagnosis and intervention,” she said.

She added that maintaining gut health through balanced nutrition and lifestyle measures may play a supportive role, although its direct impact on preventing these diseases remains uncertain.

A Shift in Neurology

“This research represents a shift in how we approach neurological disorders,” Dr. Neeharika concluded. “It reinforces the idea that brain health is interconnected with the gut, and future treatments may need to address this broader interaction.”

[mallikblogs]

7 Gut Healing Steps That Calm Anxiety Naturally

Your gut has 500 million neurons and talks to your brain 24/7. When your gut is broken — your brain feels anxious. When your gut heals — your anxiety finally eases.

How to Heal Your Gut to Reduce Anxiety: 7 Proven Steps Actually Work

Discover how to heal your gut to reduce anxiety with 7 proven steps. Fix gut bacteria, ease bloating, and finally calm your anxious mind.

[guthealth34]

Mind–Gut Connection: Advancing Research on the Gut–Brain Axis and Mental Health

Introduction

The connection between the human gut and brain has become one of the most significant discoveries in modern healthcare and nutrition science. Through a complex communication network known as the gut–brain axis, the gastrointestinal system and the brain continuously exchange signals that influence mood, cognition, immunity, metabolism, and overall well-being.

Recent scientific studies have demonstrated that the gut microbiome — trillions of microorganisms residing in the digestive tract — plays a crucial role in mental and neurological health. Imbalances in gut microbiota have been associated with conditions such as anxiety, depression, stress disorders, autism spectrum disorders, and neurodegenerative diseases. These findings are encouraging the development of innovative therapeutic approaches involving probiotics, psychobiotics, nutrition, and personalized microbiome-based interventions.

As awareness of mental health continues to grow globally, understanding the relationship between gut health and brain function has become essential for advancing preventive and personalized medicine.

Description of the Gut–Brain Axis

The gut–brain axis is a bidirectional communication system that connects the central nervous system with the enteric nervous system through neural, hormonal, metabolic, and immune pathways. This dynamic interaction allows gut microorganisms to influence brain activity, emotional responses, stress management, and cognitive performance.

The gut microbiome contributes to the production of important neurotransmitters such as serotonin, dopamine, and gamma-aminobutyric acid (GABA), which are directly linked to mood regulation and mental health. Scientific evidence suggests that maintaining a balanced gut microbiota may positively support emotional stability, memory, concentration, and stress resilience.

Current research in this field focuses on:

Psychobiotics and mood-enhancing probiotics

Gut microbiota and anxiety disorders

Nutritional interventions for depression and stress

Neuroinflammation and cognitive health

Personalized probiotic therapies

Microbiome-based mental health solutions

Gut health and neurological disorders

These advancements are creating new opportunities for integrating nutrition, microbiology, neuroscience, and personalized medicine into future healthcare practices.

Benefits of Gut–Brain Axis Research

Research on the gut–brain connection offers numerous benefits for healthcare, nutrition, and mental wellness, including:

Key Benefits

Improved understanding of mental health disorders

Development of microbiome-targeted therapies

Enhanced emotional and cognitive well-being

Better stress management and mood regulation

Personalized nutrition and probiotic interventions

Potential prevention strategies for neurological diseases

Advancement of precision medicine approaches

Improved quality of life through holistic healthcare solutions

The growing application of probiotics and nutritional therapies may provide safer, more personalized, and preventive strategies for supporting both physical and mental health.

About the Conference

Track 6: Gut–Brain Axis and Mental Health will be featured at the . This prestigious international conference will bring together leading scientists, researchers, clinicians, nutritionists, academicians, healthcare professionals, and industry experts from around the world to discuss the latest scientific developments in probiotics, microbiome science, nutrition, and gut health.

The conference aims to encourage global scientific collaboration, promote innovative research, and provide a platform for knowledge exchange in emerging areas of microbiome and mental health research.

Conference Highlights

30 CME & CPD Credit Hours

International keynote and plenary sessions

Oral and poster research presentations

Networking with global experts and professionals

Hybrid participation: In-Person & Virtual

Industry exhibitions and collaborative opportunities

Important Links

Conference Website : https://probiotics-guthealth.utilitarianconferences.com/

Scientific Sessions : https://probiotics-guthealth.utilitarianconferences.com/scientific-sessions

Submit Abstract : https://probiotics-guthealth.utilitarianconferences.com/submit-abstract

Registration : https://probiotics-guthealth.utilitarianconferences.com/registration

WhatsApp Support : https://wa.me/[phone]

Conclusion

The rapidly evolving field of gut–brain axis research is transforming the understanding of mental health and personalized healthcare. Scientific advancements continue to reveal the powerful relationship between the gut microbiome and brain function, opening new possibilities for innovative probiotic therapies, nutritional strategies, and microbiome-based interventions.

The will serve as a valuable global platform for researchers and healthcare professionals to exchange ideas, present groundbreaking findings, and explore future opportunities in gut microbiome and mental health research. Participation in this conference will contribute to advancing scientific knowledge and shaping the future of integrative healthcare and mental wellness.

[drmilindcom]

The Whole-Person Approach: Navigating Holistic Treatment for Anxiety

Holistic Treatment for Anxiety We’ve all been there—that feeling like an invisible motor is running at full speed under your skin. Your heart races, your breath hitches, and your mind begins to spin a web of “what-ifs” that would rival a Hollywood disaster script. In our modern, high-bandwidth world, anxiety has become the background hum of our lives. When we look for help, we are often…

The Whole-Person Approach: Navigating Holistic Treatment for Anxiety

[thebodycan]

You have anxiety." No root cause. No investigation. A prescription and a wave goodbye. 👋 But WHAT IF your 'anxiety' is actually: ⚡ Magnesium deficiency (racing heart, panic, insomnia) ⚡ Thyroid dysfunction (constant dread, sensitivity to everything) ⚡ Adrenal exhaustion (wired but tired, fear for no reason) ⚡ Gut dysbiosis (90% of serotonin is made in your GUT — not your brain) You are NOT broken. You are NOT just anxious. Your body is running on empty. THAT is the real message. I've helped hundreds of clients naturally resolve all of this — without a single pharmaceutical drug. 💬 Have you been dismissed with 'it's just anxiety' when you KNEW something deeper was wrong? Tell me below 👇 📞 TheBodyCan.com | 844-275-1056

[healthpont]

Gut-brain axis: how the gut influences the mind

For many years, the gut was considered a simple digestive organ, responsible only for breaking down food and absorbing nutrients. Today, however, science is reshaping this view, revealing a deep and dynamic relationship between the gut and the brain. This is not just a theoretical connection, but a complex communication network that influences mood, thinking, behavior, and even mental health. The gut-brain axis is a bidirectional communication system, where the gut and the brain constantly exchange information through neural, hormonal, and immune pathways. This communication never stops: every meal, every thought, and every emotion can affect gut function—and vice versa. It is no coincidence that everyday expressions like “I have a knot in my stomach” or “I feel butterflies” reflect this connection. Our body experiences emotions not only in the brain, but also in the gut. Modern research shows that the gut hosts trillions of microorganisms, which play a crucial role in the production of neurotransmitters and the regulation of inflammation. These mechanisms can directly influence mood, anxiety, and cognitive function. In other words, the gut is not just metaphorically a “second brain”—it truly functions as a neurobiological center that constantly communicates with the central nervous system. What is the gut-brain axis The gut-brain axis is the communication network that connects the gastrointestinal system with the central nervous system. This connection is bidirectional, meaning that the brain affects the gut and the gut, in turn, affects the brain. This communication occurs through multiple pathways, including the nervous system (especially the vagus nerve), the endocrine system, and the immune system. At the same time, the gut microbiome—the community of microorganisms living in the gut—plays a central role in this process. Essentially, it is a system of continuous “dialogue,” where chemical signals, hormones, and neurotransmitters transmit information back and forth between the gut and the brain. The microbiome: the “invisible regulator” of mental health The human gut hosts billions of bacteria that are not merely passive residents, but active participants in bodily functions. This microbial community influences the production of substances related to mood, such as serotonin, dopamine, and GABA. Remarkably, about 90% of serotonin is produced in the gut. Although it does not directly travel to the brain, it indirectly influences mood through complex biological mechanisms. Research suggests that individuals with anxiety or depression often exhibit a different microbiome composition compared to healthy individuals. This indicates that microbial balance may significantly impact mental health. How the gut affects mood and anxiety The connection between the gut and mood is stronger than previously believed. Gut bacteria can influence the production of neurotransmitters as well as the function of the body’s stress-response system (the HPA axis), which regulates how we react to stress. When the microbiome is disrupted, inflammation may increase and brain function may be affected. This can lead to heightened anxiety, irritability, or even depressive symptoms. At the same time, stress itself can impact the gut, causing symptoms such as bloating, discomfort, or digestive disturbances. This creates a vicious cycle, where the gut and brain continuously influence each other. The role of inflammation in the gut-brain connection Inflammation is one of the key mechanisms through which the gut affects the brain. When the gut environment is imbalanced, levels of inflammatory molecules in the bloodstream may rise. These substances can influence brain function, contributing to mood disorders and impaired cognitive performance. Chronic inflammation has also been linked to neurodegenerative diseases and conditions such as depression, making gut health even more important for overall well-being. The vagus nerve: the “communication highway” One of the main pathways connecting the gut and the brain is the vagus nerve. Through this nerve, the gut constantly sends signals to the brain about its condition. Gut bacteria can activate the vagus nerve through chemical signals, thereby influencing mood and behavior. The function of the vagus nerve is so essential that it is considered a key factor in regulating stress, relaxation, and emotional balance. The impact of diet on the gut-brain axis Diet is perhaps the most important factor influencing the gut microbiome. Foods rich in fiber, probiotics, and prebiotics can support gut health and, consequently, mental well-being. On the other hand, a diet high in processed foods and sugar can disrupt microbial balance, negatively affecting mood and concentration. Scientific evidence increasingly shows that caring for the gut through proper nutrition can be a powerful tool in preventing and supporting mental health conditions. How stress alters the gut Stress does not only affect the brain—it also impacts the gut. When the body is under pressure, the stress-response system is activated, which can alter the composition of the microbiome. This may lead to digestive disturbances, increased inflammation, and changes in gut motility. As a result, a cycle is created in which stress affects the gut and the gut, in turn, amplifies stress, making it harder to restore balance. The connection between the gut and cognitive function Beyond mood, the gut also appears to influence memory, concentration, and overall cognitive performance. Gut microbes produce substances that can affect neuron function and signal transmission in the brain. Studies suggest that changes in the microbiome may be associated with conditions such as dementia and Alzheimer’s disease, opening new pathways for prevention and treatment. Practical ways to support the gut-brain axis Maintaining a healthy gut-brain axis is not a matter of chance, but of daily habits. A balanced diet, adequate fiber intake, and consumption of probiotic-rich foods can strengthen the microbiome. At the same time, managing stress through exercise, quality sleep, and relaxation techniques plays a crucial role in maintaining balance. Even small lifestyle changes can have a significant impact on the connection between the gut and the brain. One body, one system The gut-brain axis reminds us that the body does not function in isolated parts, but as an integrated system. The gut and the brain are in constant communication, influencing each other on multiple levels. Taking care of the gut is not only about digestion—it also affects mood, thinking, and overall quality of life. By understanding this connection, we can make more conscious choices that support both physical and mental health. Ultimately, the gut is not just a “second brain.” It is a powerful ally in our well-being—if we learn to listen to it. Read the full article