#hematopoiesis

[bpod-bpod]

From the Heart

Study of a zebrafish model provides direct evidence that blood cells – mainly neutrophils – are produced in developing embryos by the tissue lining the heart (endocardium) and reveals the molecular signals that regulate this

Read the published research article here

Video from work by Suman Gurung, Nicole K. Restrepo and Saulius Sumanas

Department of Pathology and Cell Biology, USF Health Heart Institute, University of South Florida, Tampa, FL, USA

Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Cell Reports, February 2024

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[er-cryptid]

Hematopoiesis

-- also called homopoiesis

-- blood cell production

-- all cells are made from a single type originally

-- original cell = hemocytoblast

-- proerythroblasts become red blood cells

-- myeloblasts become      -- basophils      -- neutrophils      -- eosinophils

-- lymphoblasts become lymphocytes

--- monoblasts become monocytes

-- megakaryoblasts become platelets

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[drkarunakumar]

Aplastic Anemia: Understanding Its Origins, Diagnostic Approaches, and Progressing Treatment Innovations.

Aplastic anemia is a condition characterized by impaired bone marrow hematopoiesis, resulting in reduced levels of all blood components, including red and white blood cells, as well as platelets.

In essence, marrow aplasia represents a form of bone marrow insufficiency. When left untreated, aplastic anemia can give rise to severe complications, including irregular heart rhythms (arrhythmia) and heart failure. Continue reading to explore the historical aspects, diagnostic methods, and available treatment modalities for this condition. Given the substantial impact of aplastic anemia, it is crucial to gain a comprehensive understanding of its diverse clinical manifestations.

What is aplastic anemia?

Aplastic anemia, also known as bone marrow aplasia, is a rare condition characterized by a simultaneous reduction in red blood cells, white blood cells, and platelets, referred to as pancytopenia. It results from issues with bone marrow stem cell development. The disease progression involves:

1. Diminished hematopoietic stem cell capability.

2. Alterations in the bone marrow's chemical environment and cell interactions.

3. Elevated inhibitory immune chemicals like interferon and TNF, which can lead to bone marrow cell apoptosis.

While relatively rare, it is more common in adolescents and young adults. Severe cases, if inadequately treated, can be fatal, but milder cases often have a better prognosis. Regular medical check-ups are crucial due to the likelihood of disease recurrence.

In summary, aplastic anemia is a rare blood disorder characterized by a simultaneous reduction in red and white blood cells and platelets, leading to pancytopenia. Its causes range from stem cell issues to changes in the bone marrow environment and heightened immune-inhibiting substances. It can be present from birth or develop later due to factors like genetics, toxins, infections, immune system abnormalities, or pregnancy.

Accurate diagnosis involves a comprehensive medical history review, extensive blood tests, and precise bone marrow sampling. Symptoms can vary but often include fatigue, susceptibility to infections, and bleeding tendencies. Treatment options encompass discontinuing harmful medications, blood transfusions, antibiotics, immunosuppressive drugs, and potentially life-saving bone marrow transplants, especially in severe cases…….

FOR MORE INFO PLEASE VISIT: https://www.drkarunhematology.com/aplastic-anemia.html

dr. karuna Kumar

[email protected]

9742778093

Dr KK Hematology Clinic

No 3-9-242, 81, Siva Arun Colony, West Marredpally, Secunderabad, Telangana 500026

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[er-cryptid]

Hematopoiesis

[aalt-ctrl-del]

I wanna start doing some digging in research regarding hemopoiesis related to covid, due to the hemolytic properties induced on some people who had mild cases of covid-19. Covid-19 has been known to infect the bone marrow of those who carried the disease, like it can infiltrated the brain capillaries.

There isn’t a lot of published data on this yet - this takes far more time to collect, and the method to test the health of bone marrow tedious and painful. Through aspiration and a biopsy. The closest I could find thus far was the National Medical Library article here.

A few reports on covid and its prospected effects have noted disruption in cell production, usually red blood cells which in turn induce the hemolytic anemia, among other effects from mild covid. There is some discrepancies that are difficult to track at this time, due to how new covid is to the population. We have not seen many manifestations of acute leukemia, except in older individual who recovered - either from severe or mild covid. Additional information is pending.

I hypotheses (grammar?) we will have more results in a 5 - 10 year timeline, from the early onset of the covid spread. At earliest, 2025, if the suggested data follows rewritten cells in the bone marrow.

[jeanusmle]

Hematopoiesis