#megakaryocytes

[annietheminor]

hey..👀👀 kinda nervous but can u draw my wife (Megakaryocytes) and my cookie run oc as my sona? 👀👀👀👀 Thank u <3

My wife 👀

My only image of my sona 😭

[ take ur time !! ]

[humancelltournament]

Which cell or cell component is better?

Megakaryocytes

Cytokines

Voting ended onOct 25, 2024

Propaganda!

A megakaryocyte is a large bone marrow cell with a lobated nucleus that produces blood platelets (thrombocytes), which are necessary for normal clotting. Once the cell has completed differentiation and become a mature megakaryocyte, it begins the process of producing platelets. The maturation process occurs via endomitotic synchronous replication whereby the cytoplasmic volume enlarges as the number of chromosomes multiplies without cellular division. The cell ceases its growth at 4N, 8N or 16N, becomes granular, and begins to produce platelets.

Cytokines are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Due to their size, cytokines cannot cross the lipid bilayer of cells to enter the cytoplasm and therefore typically exert their functions by interacting with specific cytokine receptors on the target cell surface. Cytokines have been shown to be involved in autocrine, paracrine and endocrine signaling as immunomodulating agents. They act through cell surface receptors and are especially important in the immune system; cytokines modulate the balance between humoral and cell-based immune responses, and they regulate the maturation, growth, and responsiveness of particular cell populations. Cytokines are important in health and disease, specifically in host immune responses to infection, inflammation, trauma, sepsis, cancer, and reproduction.

[bpod-bpod]

Platelet Stream

Our platelets – the blood component necessary for clotting to heal injury – are not cells but nucleus-free 'fragments' produced by very large cells of the bone marrow called megakaryocytes. This study reveals how the cell cycle and the structures involved in it, such as centrosomes, are controlled in megakaryocytes to enable their specialised function – insights for producing platelets for transfusion

Read the published research article here

Video from work by by Isabelle C. Becker & Adrian R. Wilkie, and colleagues

Vascular Biology Program, Boston Children’s Hospital, Boston, MA, USA

Video originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in Science Advances, June 2024

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[er-cryptid]

Hematopoiesis

-- also called homopoiesis

-- blood cell production

-- all cells are made from a single type originally

-- original cell = hemocytoblast

-- proerythroblasts become red blood cells

-- myeloblasts become      -- basophils      -- neutrophils      -- eosinophils

-- lymphoblasts become lymphocytes

--- monoblasts become monocytes

-- megakaryoblasts become platelets

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[teenytinybat]

😮WAT!

[larryhbernsteinme]

Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets

Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets

Silk Biomaterials Produced from 3D Bone Marrow Generate Platelets Reported by: Irina Robu, PhD Researchers from  National Institute of Biomedical Imaging and Bioengineering at Tufts University and their collaborators were successful on developing developed a 3-dimensional (3D) tissue-engineered model of bone marrow that can produce functional human platelets outside the body (ex vivo). The…

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[mburatov]

Making Platelets in the Culture Dish

Bone marrow-based cells known as megakaryocytes are rather uncommon in bone marrow, but these cells are very important for the health and daily operation of the human body. Megakaryocytes, you see, produce platelets, which are critical to clotting broken blood vessels and wound healing. Generating megakaryocytes in cell culture has proven to be rather difficult, but induced pluripotent stem cells…

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