TSRNOSS. Page 196.

seen from Malaysia
seen from Maldives
seen from Türkiye
seen from China
seen from United States

seen from Switzerland
seen from United Kingdom
seen from Australia
seen from Germany
seen from Australia

seen from United States
seen from United States
seen from China
seen from Australia
seen from Belgium
seen from United States
seen from United States

seen from Norway
seen from Pakistan
seen from Pakistan
TSRNOSS. Page 196.
Oh to be a little red glucose molecule snug in the embrace of a giant blue hexokinase enzyme.
Review the kinetics of hexokinase and glucokinase!
HEXOKINASE (I, II & III) vs. GLUCOKINASE (IV) Tissue distribution * Hexokinase - Skeletal muscle (most common example even though it occurs throughout most of the body) * Glucokinase - The liver - The pancreas (its beta cells) - Less notably,
Review kinetics of glucokinase and heokinase!
By The original uploader was TimVickers at English Wikipedia
Regulators
Hexokinase is regulated by its products: ADP and glucose-6-phosphate. Hexokinase is allosterically inhibited by glucose-6-phosphate.
Glucokinase is activated by un-phosphorylated phosphofructokinase 2 and fructose-2,6-bisphosphate. They keep glucokinase in the cytoplasm and active.
Phosphofructokinase is inhibited by ATP and citrate. (See 10/10/18 lecture at around 20 minutes). Phosphofructokinase is activated by ADP, AMP (AKA adenylate), and fructose-2,6-bisphosphate.
Pyruvate kinase is inhibited allosterically by ATP. Pyruvate kinase is inhibited by alanine. Pyruvate kinase is inhibited by phosphorylation (using PKA). Pyruvate kinase is dependent on lots of fructose-1,6-bisphosphate (pyruvate kinase can “see” what phosphofructokinase is doing; if phosphofructokinase is v. active and making a lot of fructose 1,6-bisphosphate, that’s “telling” pyruvate kinase to keep making pyruvate, which you don’t want if you’re trying to inhibit pyruvate kinase)
Hexokinase binding.
(x)