#hexokinase

[biology-geology-beaches-india]

TSRNOSS. Page 196.

[gillianthecat]

Oh to be a little red glucose molecule snug in the embrace of a giant blue hexokinase enzyme.

[drawittoknowitmedical]

Biochemistry Glossary: Hexokinase vs. Glucokinase

Review the kinetics of hexokinase and glucokinase! 

[drawittoknowitmedical]

Biochemistry Glossary: Hexokinase vs. Glucokinase

HEXOKINASE (I, II & III) vs. GLUCOKINASE (IV) Tissue distribution * Hexokinase - Skeletal muscle (most common example even though it occurs throughout most of the body) * Glucokinase - The liver - The pancreas (its beta cells) - Less notably,

Review kinetics of glucokinase and heokinase! 

[brutrealism]

By The original uploader was TimVickers at English Wikipedia

[collegeandknowledge]

Regulators

Hexokinase is regulated by its products: ADP and glucose-6-phosphate. Hexokinase is allosterically inhibited by glucose-6-phosphate.

Glucokinase is activated by un-phosphorylated phosphofructokinase 2 and fructose-2,6-bisphosphate. They keep glucokinase in the cytoplasm and active.

Phosphofructokinase is inhibited by ATP and citrate. (See 10/10/18 lecture at around 20 minutes). Phosphofructokinase is activated by ADP, AMP (AKA adenylate), and fructose-2,6-bisphosphate.

Pyruvate kinase is inhibited allosterically by ATP. Pyruvate kinase is inhibited by alanine. Pyruvate kinase is inhibited by phosphorylation (using PKA). Pyruvate kinase is dependent on lots of fructose-1,6-bisphosphate (pyruvate kinase can “see” what phosphofructokinase is doing; if phosphofructokinase is v. active and making a lot of fructose 1,6-bisphosphate, that’s “telling” pyruvate kinase to keep making pyruvate, which you don’t want if you’re trying to inhibit pyruvate kinase) 

[hydrolases]

Hexokinase binding.

(x)