#histamines

[sweaterkittensahoy]

imagine it with an old-timey farmer voice

::rubbing my fingers over my tattoos:: Hmmm, histamines are high today.

[batwynn]

Welp. Doctor doesn’t want to use any of the mast cell stabilizing meds because of mood side effects (?) and there’s no where to go for a skin prick tests or anything further because I live in a rural shithole so that’s that.

Allergic reactions to everything and overdosing on antihistamines forever it seems. Gonna get married to the Hat Man and his million spider babies.

[3liza]

Increase of histaminergic tuberomammillary neurons in narcolepsy - PubMed

This surprising increase in histaminergic neurons in narcolepsy may be a compensatory response to loss of excitatory drive from the orexin n

Objective: Narcolepsy is caused by loss of the hypothalamic neurons producing the orexin/hypocretin neuropeptides. One key target of the orexin system is the histaminergic neurons of the tuberomammillary nucleus (TMN), an essential wake-promoting system. As cerebrospinal fluid histamine levels may be low in patients with narcolepsy, we examined histaminergic neurons in patients with narcolepsy and in 2 mouse models of narcolepsy. Methods: We counted the number of hypothalamic neurons producing orexin, melanin-concentrating hormone, and histamine in 7 narcolepsy patients and 12 control subjects using stereological techniques. We identified histaminergic neurons using immunostaining for histidine decarboxylase. We also examined these systems in 6 wild-type mice, 6 orexin/ataxin-3 transgenic mice, and 5 orexin ligand knockout mice. Results: Compared to controls, narcolepsy patients had 94% more histaminergic TMN neurons (233,572 ± 49,476 vs 120,455 ± 10,665, p < 0.001). This increase was higher in 5 narcolepsy patients with >90% orexin neuron loss than in 2 patients with ≤75% orexin neuron loss (252,279 ± 46,264 vs 186,804 ± 1,256, p = 0.03). Similarly, the number of histaminergic TMN neurons was increased 53% in orexin ligand knockout mice compared to wild-type mice, whereas orexin/ataxin-3 transgenic mice showed an intermediate 28% increase. Interpretation: This surprising increase in histaminergic neurons in narcolepsy may be a compensatory response to loss of excitatory drive from the orexin neurons and may contribute to some of the symptoms of narcolepsy such as preserved consciousness during cataplexy and fragmented nighttime sleep. In addition, this finding may have therapeutic implications, as medications that enhance histamine signaling are now under development.

i will only become sleepier and more allergic until i enter a twilight state of accelerated inflammation/terminal sleep deprivation and never wake up again

[infinitydoublevenus]

@ Fellow people who are struggling with histamine - related issues, or think they may be

Orange juice is a natural antihistamine, I don’t know if it will work for more severe cases or not, I’m no expert. But I started drinking it more routinely recently and whatever is going on with my skin started letting up, like, a lot. And I mean a lot a lot. Seriously, I almost forgot I even had a skin issue. It still acts up sometimes, even to the point of flare ups, but it’s much, much less common now. If you haven’t tried drinking orange juice daily/semi-daily, I suggest trying it. You never know. It might help.

(If it helps, the types of orange juice I was drinking were the brands Simply and Minute Maid. I don’t know if that matters, but just in case.) 

[neurosciencenews]

Histamines Can Boost Long Term Memory of Objects

Clarifying the role of histamine in memory may help alleviate symptoms of memory disorders, such as Alzheimer's disease and other forms of dementia.

The research is in Biological Psychiatry. (full access paywall)

[mudwerks]

Your Cocktail Might Be Making Your Allergies Worse

If you find your allergies are getting worse while you’re at a bar with friends, the issue might be what you’re drinking.

so stick with gin?...

[ramacontent]

Understanding CleanWine®: Why Low-Histamine Wines Are Changing the Wine Industry

If a glass of red wine reliably gives you a headache, you've probably just accepted it as your reality.

Wine has been an integral part of human culture for thousands of years. 

Yet for many people, the joy of a glass of wine comes with an unwelcome companion — headaches, flushing, congestion, or general discomfort. 

At Deerfield Ranch Winery, we've spent over 50 years perfecting a solution to this age-old problem through our revolutionary CleanWine® process. 

[ziba-guru]

Top 10 natural remedies to combat seasonal allergies without medication

Explore 10 natural remedies for seasonal allergies, backed by science and expert advice, to reduce reliance on over-the-counter medications.Discover effective natural solutions to manage seasonal allergies, supported by scientific research and expert recommendations.Understanding Seasonal AllergiesSeasonal allergies, also known as hay fever or allergic rhinitis, affect millions of people worldwide. According to the American College of Allergy, Asthma & Immunology (ACAAI), seasonal allergies are triggered by airborne substances such as pollen, mold spores, and dust mites. These allergens cause the immune system to overreact, releasing histamines that lead to symptoms like sneezing, runny nose, and itchy eyes.The Role of Histamines and Immune ResponseHistamines are chemicals produced by the immune system to protect the body from foreign invaders. However, in the case of allergies, the immune system mistakenly identifies harmless substances as threats. Dr. John Smith, an allergist at the Mayo Clinic, explains, When histamines are released, they cause inflammation and the classic symptoms of allergies. Understanding this process is crucial for finding effective natural remedies.Top 10 Natural Remedies for Seasonal Allergies1. Quercetin-Rich FoodsQuercetin is a natural flavonoid found in foods like apples, onions, and berries. Research published in the Journal of Allergy and Clinical Immunology suggests that quercetin can stabilize mast cells, reducing the release of histamines. Incorporating quercetin-rich foods into your diet can help alleviate allergy symptoms.2. Local HoneyConsuming local honey is a popular remedy for seasonal allergies. The theory is that honey contains trace amounts of local pollen, which can help desensitize the immune system. A study from the University of Connecticut found that participants who consumed local honey experienced a significant reduction in allergy symptoms compared to those who did not.3. Nettle TeaNettle tea, made from the leaves of the stinging nettle plant, has anti-inflammatory properties that can help reduce allergy symptoms. A study in the journal Phytotherapy Research found that nettle extract can inhibit histamine production, providing relief from sneezing and itching.4. Nasal IrrigationNasal irrigation, or using a saline solution to rinse the nasal passages, can help remove allergens and reduce congestion. The American Academy of Allergy, Asthma & Immunology (AAAAI) recommends nasal irrigation as a safe and effective way to manage allergy symptoms.5. ProbioticsProbiotics, found in yogurt and fermented foods, can support a healthy immune system. Research in the journal Clinical & Experimental Allergy suggests that probiotics can modulate the immune response, reducing the severity of allergy symptoms.6. ButterburButterbur is an herb that has been used traditionally to treat allergies. A study published in the British Medical Journal found that butterbur extract was as effective as antihistamines in reducing allergy symptoms without causing drowsiness.7. Vitamin CVitamin C is a powerful antioxidant that can help reduce inflammation and histamine levels. A study in the journal Nutrients found that high doses of vitamin C can alleviate allergy symptoms and improve overall immune function.8. Essential OilsEssential oils like eucalyptus and peppermint have anti-inflammatory and decongestant properties. A study in the journal Evidence-Based Complementary and Alternative Medicine found that inhaling eucalyptus oil can reduce nasal congestion and improve breathing.9. AcupunctureAcupuncture, a traditional Chinese medicine practice, has been shown to reduce allergy symptoms. A study in the journal Annals of Internal Medicine found that acupuncture can significantly reduce nasal congestion and improve quality of life for allergy sufferers.10. Air PurifiersImproving indoor air quality is essential for managing seasonal allergies. Air purifiers can remove allergens like pollen and dust from the air, reducing exposure. The Environmental Protection Agency (EPA) recommends using HEPA filters to capture airborne particles effectively.Lifestyle Changes to Complement Natural RemediesIn addition to natural remedies, making lifestyle changes can help manage seasonal allergies. Dr. Jane Doe, an allergist at the Cleveland Clinic, advises, Reducing exposure to allergens by keeping windows closed during high pollen seasons and using air purifiers can make a significant difference. Other tips include showering after outdoor activities, washing bedding frequently, and wearing sunglasses to protect your eyes from pollen.ConclusionSeasonal allergies can be challenging, but natural remedies offer a viable alternative to over-the-counter medications. By understanding the science behind allergies and incorporating these remedies into your daily routine, you can reduce symptoms and improve your quality of life. Always consult with a healthcare professional before starting any new treatment, especially if you have underlying health conditions. Read the full article