#antihistamines

[glittergroovy]

[missmitchieg]

HI. Yeah, uhhhhh, why in the world are we not studying the effects of Histamine blockers on PMDD because SSRI's only help about 60-70% of people and we NEED a treatment for the rest of the population SSRI's don't help. What the hell? I understand it's expensive to do these tests but people that struggle with PMDD are at higher risk for suicidal thoughts and tendencies. Maybe I just care too much about people, but I feel like that should incentivize at least looking into blockers as a treatment.

[ahedderick]

CoUGhcOUghcouGhCouGHblargh

Allegra, Zyrtec and Claritin are all supposed to work for 24 hours. Bless their hearts. However, this year, I'm noticing that 20, or even 18 hours is about all they can handle. I have years when I'm not too bothered by pollen and other years (such as this one) where I can't go outside without it. Coughing, wheezing, eyes running, misery. I guess I should just make a firm routine of taking it in the morning. If it runs out during the night, that shouldn't cause any more trouble than waking up with gooey eyes.

One more thing to remember. And me with "can't remember" disorder. yay. Once, some years ago, I walked out through my pasture, got about 150 yards from the house, realized the tall grass was getting me, and headed home. I almost didn't make it, the last few yards heading for the edge of the pasture I could feel my throat starting to close. I know this is something I should take seriously, I do. Pretty damned aggravating, though, to have lived on a farm for my whole life and, oops, the plants want to kill me.

[macgyvermedical]

Requesting a history of diphenhydramine! I read somewhere that it was the first discovered SSRI, but can’t remember where.

This will be the history of diphenhydramine as an SSRI and the drugs surrounding it. The history of diphenhydramine as a whole is longer than my standard post length and I would want to do it justice!

It was technically the first available SSRI (becoming available by prescription in 1946), but it's SSRI activity was not discovered until the 1960s, after the SSRI activity of brompheniramine (available 1955) was discovered.

Brompheniramine was the first antihistamine to be studied as an antidepressant, as it was noted to have antidepressant properties strong enough to be usable. Out of this research came the antidepressant drug zimelidine, which went to market in 1982. Two years later, this drug would be withdrawn due to reports of Guillain-Barre syndrome.

Diphenhydramine does not have antidepressant effects strong enough to be usable, but it does weakly inhibit serotonin reuptake. Out of research into the antidepressant potential of diphenhydramine, the antidepressant fluoxetine (Prozac) was created. Fluoxetine went on the market in 1986 and is the 25th most commonly prescribed drug in the US today.

[hopefully-grimderp]

Took my cold medicine that is just anti-histamines masquerading as cold meds. And I'm in a really nice place!! A reeeeeeally nice place!!

[kinsey3furry300]

Go to sleep very groggy and confused from antihistamines, wake up in the middle of the night: "Why the fuck is Hooty from the Owl House at my window? Have I summoned him by re-watching toh lately?"

Check in the morning: it's my sock dryer.

[stardustdiver]

aromantic allergy sufferers inside my phone, have you had your antikisstamines today?

[pandemic-info]

The histamine receptor H1 acts as an alternative receptor for SARS-CoV-2 | mBio

We and others have found that antihistamine drugs, particularly histamine receptor H1 (HRH1) antagonists, potently inhibit SARS-CoV-2 infection.

In this study, we provided compelling evidence that HRH1 acts as an alternative receptor for SARS-CoV-2 by directly binding to the viral spike protein. ... Antihistamine drugs effectively prevent viral infection by competitively binding to HRH1, thereby disrupting the interaction between the spike protein and its receptor.

[Drugs the study focused on:] loratadine, astemizole, azelastine, desloratadine, and cyproheptadine

Also:

Covid‐19 Histamine theory: Why antihistamines should be incorporated as the basic component in Covid‐19 management?

Several studies have shown that a number of Covid‐19 patients improved significantly when on antihistamines due to their antiviral and anti‐inflammatory properties. Moreover, antihistamines have shown to be effective in the management of long term symptoms post‐Covid‐19 infection.