#lemon frost

[donutous]

Ringo and Lemon frost

[shinyx2]

Cancer Clues Found in Gene behind ‘Lemon Frost’ Gecko Color

Research has solved a macabre mystery, and the finding could one day help efforts to catch human melanomas earlier

This is so exciting that actual research was done on this morph.

[bpod-bpod]

On the Spot

Biomedical discoveries can come from unexpected places. In a prime example, recent research has uncovered surprising links between the genetics of colouration in geckos and human skin cancer. Popular pets, leopard geckos (Eublepharis macularius) have been bred to produce many different colour varieties. For those of the Lemon Frost form (pictured), their striking colour pattern comes at a cost: more than 80% of them develop skin tumours, known as iridophoroma. By tracking the Lemon Frost pattern in a breeding colony of geckos, and sequencing their DNA, scientists were able to identify the region of DNA controlling this unusual appearance. Within it lies a single gene, SPINT1, known to function as a tumour suppressor, and mutations of which are involved in several forms of cancer, including skin cutaneous melanoma (SKCM) in humans. Linking a key gene to a visible colour difference could make leopard geckos a useful model for studying SKCM in the future.

Written by Emmanuelle Briolat

Image from work by Longhua Guo and colleagues

Department of Human Genetics, Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, Los Angeles, CA, USA

Image copyright held by the original authors

Research published in PLOS Genetics, June 2021

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[eirikrjs]

Murrer Cirstmurs Eirikrs! If you could invite four SMT demons to your own Christmas party, which ones would they be?

Thank you! It's been a relaxing one. Four demons for Cirstmurs...

I don't think my typical demon favorites would fit too well in this context. So for one of my family's parties it would have to be...

1. Lemon Frost. For flavor.

2. Putz. For all the hazelnut filling I ate in chocolates this year.

3. Onmoraki. I had wings for Christmas dinner. Have to take the chicken thing literally.

4. Erlkonig. I mean, the gifts have to go under something.

5. Agony. I would delight in informing my family that this crucified-by-barbed-wire guy bleeding profusely on the floor is in fact not actually Jesus.

Oh, it was just four. Well, this is the season of giving, after all!

[aviatory]

quik ps doodles

[followthebluebell]

Iridophoroma associated with the Lemon Frost colour morph of the leopard gecko (Eublepharis macularius)

The Lemon Frost is a new colour morph of the leopard gecko, which emerged in ca. 2015 as a result of selective breeding and spontaneous mutation. According to multiple breeders observation of Lemon Frost inbreeding with wild-type leopard geckos, Lemon ...

[jargwellprescott]

Fosh’s Lemon Frost as an upstanding respectable mare and not a thot

[sunfish-exotics]

@alwaysatomicconniseur

I have in the past but after a quick search of my blog it looks like most of it was deleted in the purge. Basically- what makes the lemon frost so beautiful (iridophores) actively become cancerous and grow tumors with time. Here is an excellent summary of some more information -> http://followthebluebell.tumblr.com/post/167461892302/john-scarborough-of-geckoboa-reptiles-just-posted

Ferret's Business

John Scarborough of GeckoBoa Reptiles just posted the final pathology reports from the lemon frost geckos.  Discussion thread here. tl;dr: