#pharmaco

[kino51]

scanners  1981

[nostalgiesornementales]

Si le neurone lui-même pratique la polymédication, peut-être le psychopharmacologue devrait-il faire de même

Psychopharmacologie essentielle, Stephen Stahl

[fluoxanax]

Okay time to catch up on pharm, i have been pushing it back for 2 weeks now

[fluoxanax]

omg if it's this ssri switch thats making me suicidal

I dO nOt KnOwS.......

[emmajackielee]

Stuff I Learned: EM Lectures

Pain Management

SSRI + tramadol = SSRI syndrome

Mental: anxiety, restlessness

Autonomic: hypertension, tachycardia, vomiting, diarrhea

Neuromuscular: hyperreflexia, rigidity, myoclonus

MAOI + pethidine = hypertensive crisis and SSRI syndrome

Tramadol lowers threshold for seizure

Buscopan = hyoscine

NSAIDs: dose for peak analgesic effect is lower than dose for peak anti-inflammatory effect

Methocarbamol is a muscle relaxant

Drugs for migraine

Maxolon = metoclopramide

Stemetil = prochlorperazine

Drug for cystitis: pyridium (phenazopyridine)

Medicolegal & Psychosocial Issues

Bruises can move (by gravity), and do not indicate the site of injury

Bruises change color

Reddish blue

Black purple

Greenish brown

Yellow

Fade

Abrasion is a breach of epidermis of skin due to friction with rough or pointed surfaces

Laceration: splitting of skin by blunt force; has bruising of wound edge and underlying tissue bridge

Cut or incision is splitting of skin by a sharp instrument with little bruising

Gunshot wound

Exit wound is larger than entry wound and the wound is more ragged

Entry wound may have an abrasion collar or gunpowder on skin

Police is not supposed to shoot from the back

Wound Management

Primary closure: 6-8 hours

Not for primary healing: abscess, ulcer, contamination, delayed wound, puncture wound, bite wound

Techniques for wound closure

Layer matching

Wound eversion: 90 degree needle insertion, vertical mattress

Wound tension

Dead space

Prophylactic antibiotics usually not necessary

Anti-rabies vaccine (ARV) is given on days 1, 3, 7, 14

[ngodingkode-blog-blog]

Pharmaco Kinesis, Frost & Sullivan Position Paper

Pharmaco Kinesis, Frost & Sullivan Position Paper

Pharmaco Kinesis, Frost & Sullivan Position Paper

View On WordPress

[bittersweetautumn]

i dun even know what am i studying now 

[-mybarbaricyawp]

Graffner et al. (Graffner C, Johnsson G, Sjögren J. Pharmacokinetics of procainamide intravenously and orally as conventional and slow-release tablets. Clin Pharmacol Ther 1975;17:414–423), in evaluating different dosage forms of procainamide obtained the following AUC and cumulative urine excretion data listed in Table 6-2. Plasma and urine were collected for 48 hr following drug administration.Table 6-2 Procainamide Data Following i.v. and Oral Administration

Estimate both bioavailability and relative bioavailability of Formulation 2 from both plasma and urine data. What are the assumptions made in your calculations? Hide Solution

From AUC analysis, F = 0.76; Frel = 0.95.

From Ae∞ analysis, F = 0.83; Frel = 0.95.

Plasma

Urine

Assumptions made are:

CL and fe do not vary between treatments.

Estimates of AUC and Ae∞ are accurate (e.g., no missed urine collections, correct extrapolations to infinity).

The half-life of procainamide found in this study was 2.7 hr. Was the urine collected over a long enough time interval to obtain a good estimate of the cumulative amount excreted at infinite time? Show Solution

Do the renal clearance values of procainamide vary much among the three treatments? Hide Solution

CLR values (Ae∞/AUC) are 25, 28, and 28 L/hr for the i.v. formulation 1 and formulation 2 treatments, respectively. The differences among them are small and probably insignificant (only mean data are shown).