have you checked out qubesos? it's a little bit resource intensive, but its design paradigm is fascinating imo
i've heard about quebes ! the containerise everything approach is pretty cool tbh ! ^w^ but i haven't tried it yet but i want to ! as well as nix and bedrock for similar reasons - nix is really just a package management system that allows the user to install specific software from specific sources w/ the exact versions of dependencies and libraries it needs and bedrock is literally a meta-distribution where you can have entire containers like an arch container and a debian container etc.
they're on my list after gentoo, slackware, artix (not that exciting but i never liked arch's move to systemd) and antiX (i got an ask about it ages ago and i still haven't got to looking into it properly)