John Lennon, Paul McCartney on train to Essen during German tour leg (1966) Photographer: Robert Whitaker

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John Lennon, Paul McCartney on train to Essen during German tour leg (1966) Photographer: Robert Whitaker
you're so obvious, kid, but we get it
The Beatles | 7 October 1964 © Robert Whitaker
NEVER SEEN BEFORE photo of John Lennon, photographed by Robert Whitaker, taken during the filming of the music video for "Paperback Writter" on May 20, 1966.
©
The Beatles, por Robert Whitaker
Eric Clapton and Charlotte Martin, a French model active in the late 1960s and early 1970s who was Eric's girlfriend (1965–1968) and later of Jimmy Page (1970–1983) with whom she had a daughter, the photographer Scarlett Page. Photo taken by Robert Whitaker in London, UK, summer of 1967.
There is no good evidence that antipsychotics provide a benefit to first-episode or early-episode psychotic patients.
In short, there is no good evidence that antipsychotics provide a benefit to first-episode or early-episode psychotic patients. Furthermore, the limited evidence that does exist on this question, as reviewed above, suggests that 40% to 67% of such patients could recover without exposure to the drugs, and that this group would, by far, have the best long-term outcomes.
So yes, it is heartening to see the drug-tapering studies. But what is also needed, and needed badly, are studies that assess long-term outcomes with selective-use models of care that avoid immediate use of antipsychotics. This Dutch study reinforces that need, for it does raise a question of whether a first year of treatment with antipsychotics, even at a moderate dose, induces iatrogenic changes in the brain that persist and take a long-term toll.