Seekers are naturally very curious and want to know everything about anything. They're curious about everything and have coding in them telling them to keep digging deeper into something, to always want to find out more and why it's that way. They have that natural instinct to dig deeper. Think of the song Wonderful Life by Zendaya from Small Foot, that's essentially seeker attitudes towards everything around them.
It's a really big problem for Megatron because if they find any little bit of information that they aren't supposed to know they'll dig the entire thing up thanks to that pull to want to know more and then they'll know too much. It's also a problem because he can't get them to just follow orders blindly at first because they have that pull to know more and why things are the way they are. He also has trouble getting them to stop working on something when they've gone far enough for him because they want to know more, sometimes ending up learning too much.
The seekers and Vos were the furthest ahead in the field of science, their city just wasn't as developed as Iacon because they wanted it that way. They dug the deepest into anything and everything so they also had the most information about Cybertron and the universe discovered. Seekers also happen to be very open minded about scientific discoveries and if something is disproved they still added it to the archives in Vos, they just made sure to mark that it was disproven. They are very aware with more science discovered it could perhaps be proven right so it's important to keep that record.
The natural curiosity also fuels ambition a bit which is partially why Starscream is the way he is.
Seekers kept a record of discoveries and other things vital to seeker culture and survival or the things that contributed to certain fields in all of Cybertron, that such, in a big library/archive of such. When the war broke out they moved it, but no one except the seekers knows where. To keep them safe, the seekers pretended that all the knowledge of the archive was lost to Cybertron.