GLUCAGON • Peptide hormone secreted pancreatic alpha cells • Counterregulatory hormone: opposes insulin action • Other counterregulatory hormones: epinephrine, norepinephrine, cortisol, growth hormone • Binds G-protein coupled receptors in sp
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GLUCAGON • Peptide hormone secreted pancreatic alpha cells • Counterregulatory hormone: opposes insulin action • Other counterregulatory hormones: epinephrine, norepinephrine, cortisol, growth hormone • Binds G-protein coupled receptors in sp
KEY MECHANISMS • Cotranslational: ribosomes continue synthesizing protein as it crosses membrane • Post-translational: protein imports after it is completely synthesized by cytosolic ribosomes COTRANSLATIONAL IMPORT OF WATER-SOLUBLE PROTEINS 1. S