#vascular function

[longhaulerbear]

People with Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Exhibit Similarly Impaired Vascular Function

This study aimed to compare flow-mediated dilation values between individuals with long COVID, individuals with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), and healthy age-matched controls to assess the potential implications for clinical management and long-term health outcomes.

The study demonstrates that both long COVID and ME/CFS patients exhibit similarly impaired endothelial function, indicating potential vascular involvement in the pathogenesis of these post-viral illnesses. The significant reduction in flow-mediated dilation values suggests an increased cardiovascular risk in these populations, warranting careful monitoring and the development of targeted interventions to improve endothelial function and mitigate long-term health implications.

[odishasamaya-blog]

Effects of Vitamin D on vascular function

http://odishasamaya.com/news/health/effects-of-vitamin-d-on-vascular-function/63164

Nutritional Vitamin D supplementation improves the vascular function and reduces inflammation in early stage of chronic kidney disease, a study has revealed.

It stated that no other medicine has proper effect in the inflammation of kidneys or any other problems related to it.

In a randomised controlled trial under direct supervision of the researchers, two ground were created of 60 patients each. “Vitamin D deficiency is common in patients with chronic kidney disease. Our study shows that simply identifying and correcting this abnormality has the potential to improve the outcomes in these patients,” said Vivek Kumar, nephrologist at the Chandigarh institute and the first author of the study.

About one in 10 people suffer from chronic kidney disease around the world. Most of these patients are destined to develop premature cardiovascular disease, said Vivekanand Jha, leader of the study group.

In a randomised controlled trial under direct supervision the researchers gave two doses of 3, 00,000 units of Vitamin D to one group of patients eight weeks apart whereas the patients in the other group received matching placebo.

Vitamin D is cheap and widely available, and through its favorable effects on inflammatory and immune functions, it has the potential to favorably influence the outcome in these patients, said the researchers. “This study has shown improvement in a range of parameters in Vitamin D-treated patients. What makes this finding of special importance is that patients in both groups were already on optimal treatment to reduce cardiovascular risk, hence the benefit of Vitamin D was additive,” Jha added.

About 70 percent of patients receiving Vitamin D demonstrated significant improvement in their vascular functions and improvement in biomarkers indicating reduction in the level of inflammatory and immune activation.

In the placebo arm, only 5 percent patients showed improved vascular function and there was no change in the inflammatory and immune markers. Neither the patients nor the study doctors were aware of which patients received which treatment till the conclusion of the study, the researchers said.

[athleticaone]

Folic Acid Deficiencies May Impact Up To Five Generations Later

Folic acid has been found to boost male fertility, vascular function and even prevent cancer. Writing in Cell, a research team revealed that epigenetic risk markers for disease caused by folic acid deficiency can be passed on up to five generations and could have an impact on developmental risk factors and later risk of disease. "Although our research focused on genetic mutations which disrupts the break down and metabolism of folic acid, we believe that folic acid deficiency in the diet would have a similar multi-generational impact on health," explained Dr Erica Watson from the University of Cambridge, who led the study. Continue reading on Preventdisease.com.