Tissue Engineering & Regentive Medicine

TERM

[tissueengineering-regenetivemed]

[downwarddeathstare]

April 25, 2017 Honored for Innovative Contributions to the Advancement of Regenerative Medicine

[tissueengineering-regenetivemed]

What may seem like science fiction is happening right here at the Wake Forest Institute for Regenerative Medicine.

450 people from 15 countries in the lab at WFIRM Winston-Salem, NC. 

[aviatior]

A New Orthopedic Stem Cell Clinic Grading System

[aviatior]

Regenerative Medicine Physician Named R&D Magazine’s 2016 Innovator of the Year

The director of the Wake Forest Institute for Regenerative Medicine and the W. Boyce professor and chair of Urology at Wake Forest University has been recognized by R&D Magazine for his advancements in the growth and regeneration of tissues and organs. (Credit: Wake Forest Institute for Regenerative Medicine)

[tissueengineering-regenetivemed]

[aviatior]

Study compares cardiac repair potential of three types of stem cells

[neurosciencenews]

Mapping NMDA Receptors

Detailed images of NMDA receptors help explain how zinc and a drug affect their function. Drugs precisely targeting portions of this receptor may have applications in Alzheimer’s, depression and schizophrenia.

The research is in Neuron. (full access paywall)

[molecularlifesciences]

The painter behind the molecular visualizations.

[tissueengineering-regenetivemed]

@aviatior

[glasshalffullurbanfarm]

One tiny zucchini harvested a couple of days before Thanksgiving. Grateful.

[tissueengineering-regenetivemed]

Featured projects for November 2016

Established in 2000, the mission of the Genomic Sciences Laboratory (GSL) is to enable discovery in the biological sciences by providing researchers and students with the necessary cutting-edge equipment and infrastructure required to conduct advanced genomics research. The GSL operates as a solution center and provides NC State researchers, collaborators, and the broader scientific community with access to high-throughput DNA sequencing, traditional Sanger sequencing and genotyping, and additional equipment services for functional genomic assays and mapping. The GSL also provides high-throughput robotics and instrumentation to facilitate the handling of large numbers of samples, as well as many advanced sequencing and sequencing support applications developed independently by NC State faculty.

[tissueengineering-regenetivemed]

Immune Haplotypes in Zebrafish

The zebrafish has proven to be an extremely amenable model system for genetic and developmental studies and more recently, the modeling of human disease. The availability of a high quality reference genome has accelerated these studies. However, resequencing of zebrafish genomic and transcriptomic loci has revealed the wide extent of not only SNPs but also gene content haplotypes within multigene families; individual zebrafish encode variable numbers of related genes due to frequent gene gain and loss events. Families of immune-related genes, including NITRs, DICPs, PIGRLs and NILTs, that are clustered in the genome exhibit dramatic gene content haplotypes. Whole Transcriptome sequencing using NGS platforms are helpful to resolve gene content haplotypes as prior knowledge of the sequence is unnecessary. De novo transcriptome assembly of the deep coverage obtained through RNAseq by NCSU’s GSL has allowed us to discover many novel immune-related genes absent from the latest versions of the zebrafish genome assembly. Currently, multiple projects in the Yoder lab (CVM) are underway to determine (i) the extent of gene content haplotypes in multiple genetic backgrounds of zebrafish and (ii) how gene content haplotypes observed in multigene families of innate immune receptors influence the individual response to immune challenge.

[tissueengineering-regenetivemed]

[tissueengineering-regenetivemed]

Humans wear out over time

Since my job is heavily focused on working with research and development, I decided to share interesting info via this blog. Tissue engineering and regenerative medicine (TERM) will continue to shape our world in ways that will change the human experience. What is Tissue engineering and regenerative medicine? https://www.nibib.nih.gov/science-education/science-topics/tissue-engineering-and-regenerative-medicine