I feel like not enough people realize that people under enormous strain act really really fucking Weird
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@androgenetics
I feel like not enough people realize that people under enormous strain act really really fucking Weird
does the body ALWAYS have to keep the score? maybe we could just have a friendly game this time. maybe we can just have fun without putting numbers on it
the beauty of life
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using violence to liberate people from sweatshops, unsafe mines, and grinding poverty isn't the same as using violence to impose those things on people. the idea that violence is morally repugnant regardless of context is a belief that every oppressor throughout history would love for the oppressed to hold
I need a day between every day to recover from the day before
when i was a kid i decided that killing people was bad therefore war was bad therefore the military was evil. and adults would tell me it's more nuanced than that and i would understand when i grew up. well i'm a grown up now and idk i still think that killing people is bad and war is bad and the military is evil
hate when I type :) and this 🙂 fucker appears. Go away you evil soul
For anyone unaware, this week Scotland elected our first ever trans members of parliament
🩵🩷🤍🩷🩵
💛🤍💜🖤
@this-is-trans-joy
This is trans joy!!!
“i should take a walk for my mental health” boring, tired, i don’t even really wanna do it tbh
“i need to check the perimeter” i need to check the perimeter
the cognitive dissonance from people who want the products of modern medicine but get weird about animal research. like im sorry but this is necessary for the survival of the society we currently live in. and the scientists who work on these things are not evil cackling psychopaths. anyone you talk to in animal research has incredibly complex feelings about their work and incredibly complex relationships to the animals in their care. there are regulations and oversight and penalties in place to make the work as humane as possible and scientists are overwhelmingly the ones enforcing and advocating for better care.
@velvetdemon I'm doing a full reply because I want to give this question the time and space it deserves, and I really do appreciate your curiosity about this.
The short answer: It is deeply unethical. There are nowhere near enough willing patients in the world to be able to do this, and it would be criminal to put them through this.
The long answer: The one side of the equation you're focusing on is: how much of a drug is too much, to the point where it will cause negative side effects or even death? And this is crucial to know. But it's not just a matter of finding out the lethal dosage of a heart cholesterol medication, you need to know that it can actually lower the cholesterol of any living thing. There is no way to know this without giving it first to...a living thing.
But beyond this, I need to emphasize: The goal of a drug trial is to effectively cure people who are already suffering from disease, who are living on limited time.
Drug trials don't just happen on any member of the public, they need to happen specifically on people affected by the disease you're trying to treat. There is at any time a very limited and very marginalized population of the world affected by early onset, familial Parkinson's disease. Because you cannot ethically induce disease in a human being, you are working with, speaking with, and helping patients and their families who are hopeful and desperate for a cure.
If you were to jump straight to human trials from petri dishes, not knowing absolutely anything about how the drug functions in a living, breathing animal body, it would look like this:
We didn't know that minute quantities of the drug interact lethally with x, y, z medication that people are commonly also taking. X number of patients have died as a result.
We didn't know that the drug is fatal to people with [common variant] in their genetics. X more patients have died.
We didn't know the drug exacerbates x, y, z chronic illnesses. X number of people have acquired permanent, lifelong disabilities.
We didn't know the best way to deliver the drug, so we tried multiple ways: the people who received it intravenously are now suffering from a painful, costly, and debilitating condition that did not happen with the ingested form.
I could go on, and on, and on.
The vast majority of these problems can be nearly or almost entirely averted by testing other animals first.
These are all people who possibly could have waited for the normal progression from animal testing to human testing and thus received better outcomes. Some people will pass away in the time it takes to get to that point, and that's heartbreaking, and we all wish science could be faster.
But the cost of expediting science could mean a life of profoundly greater suffering or an even shorter life than the one where no intervention happens at all. And at that point, you have completely exhausted your trust, your goodwill, and your patients' hope, after you've failed to do anything or even worsened the lives of people who are already deeply suffering.
hi, i’m an animal research professional. making sure laboratory animals stay alive, healthy, and enriched has been my full-time job for several years now.
animal research is not the mad scientist wild west that PETA wants you to think it is. there are extremely strict federal laws in place to protect the well being of these animals. animal welfare organizations like AAALAC ensure that lab animals are treated with dignity & respect and are given enough specialized care & enrichment to be happy and content in captivity, just like AZA accreditation with zoos.
not a single animal from a zebrafish to a mouse to a dog to a macaque goes unaccounted for. if an animal gets moved to a new cage, paired for breeding, has a procedure performed on it, gives birth, gets sick or injured, dies, etc. it is legally required that this information is recorded and kept on file for the US federal government to access. failing to record & retain this information is very much punishable by US federal law.
let me tell you - if you abuse or kill an animal, even a mouse - you are almost certainly getting both fired & blacklisted from the industry. if you abuse or kill a more ‘advanced’ animal, such as a dog or monkey, you will likely face criminal charges. killing a monkey is as serious and disastrous as a nuclear meltdown. you are expected to reasonably explain every illness, injury, or death of an animal under your care. you must record all of this information. animals that are clearly suffering with low QOL are required to be euthanized according to AVMA guidelines.
research animals are highly expensive. yes, even the "lesser" animals like mice. the cheapest mice will run you a few hundred $ per individual, with some of the most expensive mice i've cared for being $25,000 per individual. in research we have the "three Rs" - reduction (reduce amount of necessary animals to a minimum), refinement (refine processes to ensure research is accurate and animals feel no pain or distress), and replacement (replace animals with non-living research models as they become available). i can assure you no proper research team is wasting animals (*do not* say "b-b-but elon musk--" his research team is actively being investigated for animal abuse by the government).
research methods that do not require live animals are currently being looked into & efforts spearheaded by - you guessed it - the animal research industry itself (notice how the animal rights people are strangely silent & unhelpful when it comes to this?) but current technology is rudimentary and does not compare to live animal models.
some research animal fun facts (US edition):
all species of animals are only allowed to have one single major surgery performed on them in their entire lifetime.
institutions with nonhuman primates must have a behavior program in place (run by knowledgeable primate specialists) to ensure that they are happy and receiving enough daily enrichment and social interaction.
institutions with dogs are required to have physical exercise programs in place. this means every individual dog gets a substantial amount of leashed AND free-roaming exercise daily, including playgroups with other dogs.
a majority of nonhuman primates get to retire to sanctuaries like peaceable primate sanctuary, and almost all dogs get retired and adopted out by organizations like homes for animal heroes. some institutions will also adopt out unneeded young rabbits, guinea pigs, rats, etc.
some strains of mice glow neon green (or orange or blue) under UV light. this is not harmful to them and is commonly seen in cancer research.
so yes, you can rest knowing that laboratory animals are treated with the utmost respect by their caretakers. and you can stop this awful, ignorant talk of human experimentation that will only end in the abuse of nonwhite people, LGBT people, disabled people, indigenous people, and so many others. please just take a look at this wikipedia page if you think “ethical” human experimentation can exist.
If you want to reduce animal testing - or at least, reduce the amount of things we need animals to be tested with - there is some growing traction in regards to mathematical modelling (also known as in silico studies), in vitro studies (i.e. test tubes), and 3D printing of organoids.
At the moment, this is not a substitute for animal testing. Bodies are incredibly complex and interconnected environments that we're still scratching our heads about, and animal testing is in a lot of ways the most efficient and least harmful way of testing things like medications.
If anyone wants to read more about these subjects, here are a few starting points (you will probably learn some new words, this is okay!):
Advances and Applications of Predictive Toxicology in Knowledge Discovery, Risk Assessment, and Drug Development research topic by the Frontiers in Pharmacology journal
Novel methods and technologies for the evaluation of drug outcomes and policies research topic by the Frontiers in Pharmacology journal
Spotlight on Artificial Intelligence in Experimental Pharmacology and Drug Discovery research topic by the Frontiers in Pharmacology journal
The Emerging Discipline of Quantitative Systems Pharmacology research topic by the Frontiers in Pharmacology journal
PDF Drug Combinations: Mathematical Modeling and Networking Methods by Vahideh Vakil and Wade Trappe
PDF Machine learning-based drug-drug interaction prediction: a critical review of models, limitations, and data challenges by Flaviu-Ioan Gheorghita et al.
PDF A review of 3D bioprinting for organoids by Zeqing Li et al.
3D Bioprinting for Engineering Organoids and Organ-on-a-Chip: Developments and Applications by Yuqing Ren, Congying Yuan, et al.
3D bioprinting of human iPSC-Derived kidney organoids using a low-cost, high-throughput customizable 3D bioprinting system by Jaemyung Shin, Hyunjae Chung, et al.
PDF Advancing organoid development with 3D bioprinting by Wenping Ma et al.
And, in order to obtain the stem cells required to make some types of organoids, in Canada, the ONLY embryonic stem cells that are legal to use in research must come from the extra “waste” embryos donated by couples who have already undergone IVF intending to have a baby. This means we only use embryonic stem cells that would otherwise be medical waste. Just like with animal research, it is extremely highly regulated.
I’ve had tumblr for 4 years but some of you bitches have had it for a decade. It’s time to seek penance
wait I’m curious now . Reblog this with how long u’ve been on tumblr for. Dating back to ur oldest blog ever !!!
For anyone who wants to see the exact date and time you started on tumblr:
Tumblr is a place to express yourself, discover yourself, and bond over the stuff you love. It's where your interests connect you with your
How long have you been on Tumblr?
< 1 year
1-2 years
3-4 years
5-6 years
7-8 years
9-10 years
11-12 years
13-14 years
15-16 years
17-18 years
Since the beginning (19 years)
Round to the closest year! I couldn't figure out the best way to succinctly communicate, for example, >10 but <=12 in a way accessible to people with varying degrees of comfort with math notation.
approximately poisson-distributed.
is this not just a photo of an Arabidopsis thaliana plant?
really one of the things i hate most about the ai fuckening we're currently in is that it positions me as the person wearing a tinfoil hat when i try to suggest that maybe handing over biometric and personal data to tech companies is bad, actually.
like maybe perhaps perchance we don't want it scanning our children's faces to do age verification because we don't know what it's going to do with those scans down the line. maybe we shouldn't be using it like a therapy machine and telling it our deepest, most painful things. maybe we shouldn't be giving it a dossier of our detailed medical information, especially in a world (in the us) where things like not being able to hold pre-existing conditions against someone for insurance is increasingly threatened. perhaps we shouldn't be scanning our faces for funny little short videos into something that can also generate porn on demand with all of the data it's collected.
maybe, stay with me and please stop building the tinfoil hat i can see you putting on my head coworker/friend/casual acquaintance, ai ISN'T a miracle to solve humanity's problems and is instead just more tech churned out by tech bros who have not historically been super great when it comes to morals.
it really is interesting how most adults really only see child sexual assault through the lens of how it makes THEM feel. it's not really about the actual harm that comes to the children, it's about how they, the adult (the real victim) feels about the fact that a child or children got abused and taken advantage of.
like one time I saw a vid of some dudes who tricked some guys into thinking they were going to meet up with minors, instead they forced the two dudes to fight on camera. it's voyeurism, it's not about protecting children it's about the good feeling YOU, the viewer, get inside when you watch this happen.
or like I was arguing with some people about CSA being punishable by death. i don't care if child abusers die, let me say that. wouldn't care if they all killed themselves to a person. but there is a REASON child advocacy organizations will tell you that executing convicted pedophiles is a bad idea, and that's because it will lead to more children being killed to hide the crimes of the abuser.
But if you argue against THE STATE executing pedophiles, people start pulling the "ohhhh wow defending pedophiles. this the hill you wanna die on?" like no dude I just think about the effects of policy outside of the fucking feel-good yummies in my tummy I get from seeing someone I don't like punished.
Why are subs always unemployed 😭 bitch you love getting told what to do and being taken advantage of you d loveee having a job😭😭