If you hate kids you will NOT fucking change your mind when you have your own. You will have kids you hate taking care of and they will be able to tell. These children are human people and you will fuck them up for the rest of their lives. Don't do that 👍
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.
That routine just changed.
On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.
This is not a minor update to an existing drug.
It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.
Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.
That means reducing from 365 injections a year down to just 52.
For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.
It represents relief.
How the Drug Actually Works
Understanding why this injection lasts a full week requires a quick look inside the body.
Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.
Awiqli works differently.
Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.
This attachment creates a slow-release reservoir.
Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...
What Comes Next
Awiqli is not standing alone in this space for long.
Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.
If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.
The broader direction of travel in diabetes care is unmistakable.
Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...
A Small Shot With Large Implications
It is easy to look at a once-weekly injection and see only a scheduling change.
But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.
Diabetes management has always asked a lot of people.
It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.
Anything that reduces that load, without reducing the quality of care, is worth taking seriously.
For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.
That is the real significance of what the FDA approved on March 26, 2026.
Not just a new drug.
A new way of keeping people healthy, one week at a time.
love that fl lures you in with body horror only to stab you in the liver with identity horror. how many of your memories can you lose to the eldritch purple before you're fundamentally a different person? what if you could only escape an oppressive destiny by becoming a fish? are you really human, or are you actually a pile of spiders wearing stolen memories and a very convincing skin-suit? who can say
Transphobia is about to be signed into law in the UK. We can fight this.
I am begging the UK trans community and its allies to attend the Mass Lobby at Parliament on June 25th, 11am-4pm, organised by Trans Solidarity Alliance.
Last year we broke the record for an LGBT+ mass lobby of Parliament. Will you help us break it again? Join us on 25th June 2026 to demand be
The new EHRC Code of Practice pushes trans people out of toilets, hospital wards, and community spaces. It normalises gender policing based on appearance and stereotypes. It becomes statutory guidance in the UK by the end of June.
Trans people are now legally their assigned gender at birth and must join gendered spaces accordingly, but if they are perceived as their lived gender, they can also be ejected from those spaces. The guidance says: either break the law, or don’t pass too well.
A mass lobby is where you invite your MP to discuss your concerns with you in-person. Ask your MP to:
Demand full parliamentary scrutiny, debate, and use their free vote on the EHRC Code of Practice.
Support any motions rejecting the EHRC guidance. As of June 4th, Labour MP Nadia Whittome has submitted a prayer motion - Early Day Motion 240.
Write to Bridget Phillipson, the Minister for Women and Equalities about our concerns
Your MP does not have to be an ally, they do not have to respond to your email for you to show up and greencard them (details below the cut.) What matters is that as many people as possible show up.
I cannot stress this enough: Showing up in person matters. It is much more effective than petitions, emails, and letters.
It is a horrible, stressful time, and I am so sorry if you're trans and live in the UK. But I was at last year's mass lobby and the line for greencarding alone stretched around the back gates. It was a record breaking mass lobby and made us impossible to ignore. Let's do even better this time. Details under the cut:
Worried about what to say?
Bring your personal worries about transphobia being signed into law, and trans friends being excluded from public spaces. You are a living person who deserves dignity. Remind your MP of that. You will also get guidance and brochures from Trans Solidarity Alliance that outlines our demands. This is mine from last year.
Money issues?
Trans Solidarity Alliance provides a travel bursary that you can sign up for via the link.
Got a refusal or no response from your MP?
Come anyway! You can request a same-day appointment with your MP through a process called greencarding. They will come and see you if they’re already in Parliament. Even if they don’t, they’re made acutely aware of your cause because you showed up in person. This is my greencard from last year.
Here is the EHRC Code of Practice in full. It's a tough read, but some highlights are:
Organisations can’t provide trans-inclusive, single-sex services, or they risk being sued for discrimination.
e.g. domestic violence support for women including trans women, men’s rugby group including trans men (12.68).
Trans people will have nowhere safe to pee.
If you’re a trans man, businesses can't allow you to pee in the men's, and you can also be ejected from women’s bathrooms if you’re perceived as a man. Vice versa for trans women. EHRC suggests a ‘third space’ bathroom, which is discriminatory and unworkable for most businesses. (13.130-133)
Sports organisations must exclude trans people from single-sex competitions (13.73).
A women’s only sports competition must exclude trans women because of their biological advantage or face potential lawsuits (13.74), but a trans man who has undergone testosterone treatment can also be excluded based on fairness rules (13.81).
Trans women are stripped of the legal definition of ‘lesbian’, and therefore no longer have legal protections if they’re discriminated against on the basis of sexual orientation. (2.50, 2.92).
Here is the Good Law Project's better explanation of the EHRC Code.
I have also made a PDF printout of QR codes for the government petition, email your MP tool, and mass lobby link to pass around your communities. DM me and I'll send it to you.
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