Dave writes: I am often asked about the top supplements I recommend, or "What is the best supplement program from glaucoma." I think it is valuable to have a list of the best or most recommended supplements. I provide suggestions on supplements all the time, and I will be working on a new complete list of recommended supplements. However, before I do that I want to share a perspective on the best supplement program that goes beyond a list of products. I think it will be the less-appreciated, less-liked than a list of hot new products, It's just not the "fun" thought-provoking answer that will stimulate our minds. But it is an important perspective, and I want to share it with you. For this answer, I am going to emphasize three points:balance (and synergy) - this often equates to complexity when it comes to health matters tracking (personalization)a natural foundationThe best supplements are often the most boring. We know that from our recent discussion on vitamin B3. Many of us are electing to use old-fashioned, cheap, boring niacinamide instead of NR or NMN. Some of us are using a combination. But I don't think any of us are ignoring the value of the older, "boring" vitamin B3, even if we also use NR or NMN. In fact, the best supplements are often foods, superfoods, herbs and spices. For example, I eat one brazil nut per day for selenium (although with COVID-19, maybe you could increase that to 2 or 3 per day, but as glaucoma patients we want to be attentive to not overloading selenium). I eat a teaspoon of hemp seed hearts, a teaspoon of freshly ground flax seeds, and a few raw, organic walnut halves daily. These are all superfoods. With these and attention to my diet, I easily maintain a ratio of arachidonic acid (AA) to eicosapentaenoic acid (EPA) in plasma of between 1 and 2, which is the ideal range according to the studies I think are best. For example, on a recent OmegaQuant test, my AA:EPA ratio was 1.3 (which can also be written as 1.3:1). The higher the AA:EPA ratio, generally the higher are the levels of cellular inflammation. EPA is anti-inflammatory while arachidonic acid is pro-inflammatory. An AA:EPA ratio of between 1 and 2 is considered to be ideal. This is the ratio found in the Japanese population having the greatest longevity and the lowest incidence of cardiovascular disease. It is not uncommon in the developed world to see an AA:EPA ratio of 20, 30, 40 or even 50. In another health-oriented community I know, the average ratio in a survey was 10. That is within the "good range" according to many labs and far better than average. Getting it down to 2 or below is rare in the USA. Fish oil supplements can help a lot, but the superfoods I mentioned above (hemp, flax, walnuts) are essential in a complete solution. Telling you to achieve an AA:EPA ratio of between 1 and 2 is not as exciting as the news I shared recently about TUDCA, for example. Taking a pill is a lot easier than changing your diet. But the real results come when we also do more than just take a pill. (That said, when I started taking TUDCA, it did feel life-changing for me. But again, even in that case, I also made a number of dietary changes along with starting TUDCA. I almost never look to a supplement as the total solution. I firmly believe all lifestyle factors, such as food, sleep exercise, stress management are essential.) I do not have to emphasize how important it is to maintain low levels of systemic inflammation. That's a huge key to staying healthy today. The higher your inflammation levels, the higher is your risk of developing chronic disease. Chronic systemic inflammation is a problem in everything from CFS-ME to heart disease to diabetes. It is most definitely a problem in glaucoma. The AA:EPA ratio is an important biomarker for achieving your goal of low systemic inflammation. Another thing I do, largely through diet (although again, fish oil supplements help) is to keep a very favorable omega-6 to omega-3 ratio. Mine was recently 2.1. It is quite common to see this value as high as 10, 15 or even 20. What are my main points? One of my main points is that the best overall supplement program is about balance. It is not just about the hottest products on the market right now. It is not just about taking high doses of single ingredients. I am now taking 3200 mg of PEAmium per day, and I will probably up my B3 to 3000 mg/day, so I am not against this at all. But I don't want us to lose sight of the biggest picture when it comes to supplements. There is no one single supplement at will "cure" glaucoma. In my experience, when experts come up with formulas for a supplement and they want to get everything into a single product, reality forces compromises. I know of a famous glaucoma formula that has only 250 mg of B3. Obviously, that is not enough. We want at least 500mg and probably at least 3000 mg. But with this formula, if you double the dose and achieve the model intake of 500 mg of B3, you will be getting far too much of at least one other ingredient in the formula. This is very common with formulas. It becomes nearly impossible to achieve an ideal balance in a single product. Unfortunately, this means that our ideal and balanced supplement program is going to consist of a sizable number of products, and that we are going to have to perfect our combination of products (which leads to my next point). Another point is that we have to pay attention to the boring details. This requires tracking. I like to use lab tests and home tests for quantitative feedback, such as the numbers I gave above. I like to stay near my optimal targets for nutrients and biomarkers. I also see a lot of value in tracking your symptoms along with your diet and other activities. Through tracking (although it can be tedious and boring), you can accomplish the rewarding work of perfecting your own dietary supplement program. This is how you achieve balance and this is ultimately how you achieve improved and optimal health. All of you know the great emphasis FitEyes has always placed on home IOP monitoring. I believe every glaucoma patient would benefit from doing this. How many times have you heard a top athlete say, "its all about the fundamentals." It is. Even when you are the world's best athlete, you spend most of your time paying attention to the fundamentals, to your foundation. to the basics -- the same foundational skills that are taught to beginners. By paying attention to the details over time, you get much better at executing. And while new discoveries and advanced technologies may give you that fraction of a percent edge, the bulk of what makes the difference -- and this applies whether you are a top athlete or an individuals seeking better vision and overall health -- is in your attention to the fundamentals. To continue the analogy, the same way an athlete keeps a training journal and a coach keeps data on the individual players, to achieve your goals and to arrive at your own "best supplement program" you have to carefully track your results, including your IOP. You actually have to write stuff down (ideally in the computer or by using the FitEyes Insight software, not on paper). Another of my main points is that the best supplement program is one that includes a very wide range of nutrients. I do use (and recommend) a fair share of nutraceuticals and supplements that contain one single ingredient. However, the foundation of the "best" supplement program needs to be built on superfoods, full spectrum herbs and natural supplements that each contain hundreds or thousands of naturally occurring nutrients. While I have nothing against taking an EPA (eicosapentaenoic acid) supplement (and I do take one), when I also get omega-3's from hemp seeds, flax seeds and walnuts, I am getting fiber, minerals, omega-3's and hundreds if not thousands of additional nutrients. Some of these nutrients have not even been identified by science yet. New supplements will come out in the future based on new discoveries. However, if our supplement program is built on a foundation of superfoods, we don't have to wait for these hidden nutrients to be discovered and packaged into a supplement. We are already getting all those nutrients. Here's an example. I recommend turmeric. A few years ago curcumin was the "the molecule of the year" in medical research and a very hot selling product. I stuck with recommending full spectrum turmeric. The FitEyes store missed most of those sales. But I stuck to my principles. Later, scientists came to recognize that curcumin is not the only important ingredient in turmeric. The multiple turmerones in turmeric are now recognized to have important benefits and some have even called the turmerones "curcumin's more powerful cousins." So why were we isolating curcumin out of turmeric and throwing away lots of other valuable and beneficial compounds? (In some cases, this strategy makes sense because we need to remove components of a plant that could be toxic.) However, turmeric is a very safe spice with a long history of human use and I do not believe it makes sense to take curcumin without at least having a foundation of full spectrum turmeric. We can take a top quality turmeric (or even add it as a spice to our food) and get all the beneficial compounds science recognizes today while also getting anything else science may discover in turmeric in the years ahead. In summary:balance - health is complex. Science does not understand everything about human biochemistry. There may be more that is unknown than known. No single chemical, whether pharmaceutical, nutraceutical or vitamin, is likely to be the "one best solution". Medicine has been trying to find a "cure" for glaucoma for more than 100 years. Glaucoma is complex. The solution for a complex chronic condition like glaucoma is almost never just one thing. Often, even surgery which achieves the ideal IOP value is not enough. My experience is that the "best supplement program" for any chronic condition is a complex combination of supplements that addresses a number of factors, and by addressing all of this together in a synergistic way, we create the balance that leads to great health. I do not recommend single all-in-one products because they are always too limited to achieve the personal balance we need. tracking - keeping written records and using them to refine your nutrition and supplement program over time is essential to creating your personal best supplement program.a natural foundation: superfoods, good nutrition, full spectrum, natural supplements often get less attention than the patented nutraceutical, but they must be your https://bit.ly/322s5g1 "best" list of supplements for glaucoma includes both natural supplements and nutraceuticals. Both have a place, but the foundation needs to be natural -- foods, superfoods, full spectrum herbs, spices, etc. This is one reason why we carry both Nordic Naturals (which are pharmaceutical grade fish oils) and Green Pasture Fermented fish oils (which are pre-industrialized foods that are more natural than any other fish oil in the world). I use Green Pasture as my foundation, and I take Nordic Naturals EPA to fine tune (or balance) my program and to achieve my target on the AA:EPA ratio biomarker. (I also take Pro DHA Eye.) https://bit.ly/34gk3Ts