I like the idea that Peter is as much unhinged about Wade as Wade is about him, but he's so emotionally repressed that it comes out very sporadically and in a way that's just ambiguous enough for Wade not to catch it.
Wade and Peter are on rooftop, talking and eating takeout after a mission.
Wade, rambling as always: - And then he told me that I was the most hideous thing he ever saw and that I should like, sew my mask to my face to be visually bearable to the general public, which is funny because I know where he willingly puts his dick sometimes and let me tell you-
Peter, who was clearly zoning out of the conversation, suddenly very focused: Who said that?
Peter: Which villain said that shit to you?
Wade: Villain? no it was Tony Stark. During yesterday mission.
Peter, actively preparing the webs he's gonna put in every engine of Stark's favorite cars: Huh, how funny of him.
Peter: Pool, you've gotta stop throwing yourself at dangerous individuals you don't know the powers of.
Wade: Listen baby, with all the freaks around here there has to be at least one who can put me down definetely. I just have to annoy the shit out of anyone with any kind of power and see which one sticks.
Peter: Anyone kill you, I'm gonna make their lives hell on earth.
Wade, joking: Awww, spidey babe, I'm gonna be the one who makes you break your no kill rule?
Peter, absolutely not joking: Yep.
Peter: Oh my God Deadpool, you are being so damn jittery. More than usual. You have ants crawling under your skin or something?
Wade: Huh, might as well.
Wade, shrugging: You know how it is, some flare ups. Every inch of skin feels like it's being burned with acid, my bones are aching something fierce and it feels like my brain is being boiled inside my skull. The usual. Oh there is this new chinese place in the corner, we should-, Spidey, are you good?
Peter: No I'm not good! You are in pain, you shouldn't be here!
Wade: Webs, I'm always in pain. Every second of every day I'm in pain. This is fucking thursday for me, just a slightly shittier thursday. But you know what would make it less shitty? having chinese food after the mission! You good with that?
Peter, actively having a breakdown about never noticing Wade suffering, thinking that if anyone dares to even put a scratch on Wade during the mission he's going full berserk on them: ... Sure. I'm paying.
Random villain: With that healing powers, torturing you will be fun. I'm gonna drag it out, and I'm gonna enjoy it.
Wade: Uuuuh, kinky. Maybe I will let you, if you're entertaining enough. Should we give him a chance Spidey?
Peter, about to put this asshole trough the nearest death experience ever: Yep, let's see him try.