Researchers who discovered a mechanism that prevents B cells from attacking the bodyâs own tissues in autoimmune diseases win Crafoord Prize
"Two researchers in the US and Australia have discovered important mechanisms that prevent B cells from attacking the bodyâs own tissues in autoimmune diseases like arthritis, lupus, and multiple sclerosisâand in the process have won a prestigious prize.
Normally, the bodyâs immune system protects us from viruses, bacteria, and foreign substances. However, in autoimmune diseases, the immune system starts attacking tissues in the body instead.
Researchers had long tried to discover the cause of autoimmune diseases. But, Christopher Goodnow and David Nemazee, independently of each other, adopted a new approach.
They asked why we do not all develop these diseases. Their focus was on B cells which, together with white blood cells and T cells, are the building blocks of our complex immune system.
âThey have given us a new and detailed understanding of the mechanisms that normally prevent faulty B cells from attacking tissues in the body, explaining why most of us are not affected by autoimmune diseases,â says Olle KĂ€mpe, member of the Royal Swedish Academy of Sciences and chair of the Crafoord Prize committee that awarded the pair 6 million Swedish kronor ($600,000).
Neutralize B cells
In recent years, physicians have started to experiment by using existing drugs to neutralize B cells for patients with severe autoimmune diseases, including lupus, rheumatoid arthritis, and multiple sclerosis, which has proven to be very effective at improving their quality of life.
Thanks to this yearâs Crafoord Prize Laureates, we have gained fundamental new knowledge about what is happening in the immune system during autoimmune disease attacks.
âThis also paves the way for development of new forms of therapies that eventually can cure these diseasesâor might prevent them in the future,â said one professor of clinical immunology at the Royal Swedish Academy of Sciences...
More details from the video, since the article glosses over the particulars:
"The laureates discovered what is now called B cell tolerance.
When B cells develop in the bone marrow, not all of them are perfect. To remove the faulty ones, a mechanism starts, in which defective cells are programmed to destroy themself through apoptosis.
The laureates discovered two new mechanisms that are used if some of the bad cells are left. Re-editing, where the immune system alters the combination of receptors, and anergy, that silences B cells with self-reactive receptors.
The laureates were able to demonstrate that these mechanisms sometimes fail. This means that faulty B cells can cause an attack on the body's own tissues â leading to autoimmune diseases.
Thanks to the laureateâs discoveries, doctors like Anders Bengtsson soon felt able to start treating patients with lupus, arthritis, multiple sclerosis, and many other autoimmune diseases, with medicines that eradicated B cells.
Anders Bengtsson: "I'm very happy that B cells has gotten so much attention because of the laureates. I have seen my patients getting so much better and getting a better life."
Autoimmune patient: "Today, I feel very good. I really have hope in the research that it will revolutionise things and perhaps even cure it all. Thatâs what I want, hope for, and believe in.""
-Article via Good News Network, April 6, 2025. Video via The Royal Swedish Academy of Sciences, January 29, 2025.
Small continuation of this role swap doctor Sanji art bc I couldn't get out of my head how funny it is that it meant that Zoro and Mihawks fight happens outside an A&E in this universe
Already seeing people on tiktok saying âI still hate trump but he ate with this oneâ like ⊠babes ⊠you just got propagandized ⊠thatâs literally exactly what he created this situation in the hopes you would say âŠ
you've got 2 admit that the oft repeated command to "touch grass" in itself illustrates a great disconnect from the tru wholesomeness of the offline world. unless you meant a kind of wild grass, a lovely tassel cord rush or even the humble rattlesnake grass. but we know that's not what they mean. to the chronically online, grass = lawn and nothing more. and a lawn is an abomination on par with the worst brainworms big online has to offer. touching a lawn will not help you. You've got to go injure yourself on some swordgrass for god's sake
Counterpoint: If you are so terminally online that touching *manicured suburban monoculture lawn* is an improvement on your connection to nature and reality, then the implications of the statement are magnified
But also consider that what grass is For is running around on. Maybe kick a ball or throw a frisbee. It's not about nature necessarily so much as being active in the physical world.
another angle is that if you're touching grass, unless you're barefoot, you're probably leaning down or even sitting or lying on the ground. you're taking it slow, at a picnic, in the park, enjoying a nice day out, maybe the sun is on you, and it's probably warm. maybe you're picking wildflowers. maybe you're making a little daisy chain to put on your head like a flower crown. no phones in site, only you and the green stains on your hands from picking blades of grass. whatever you're doing, the vibes are immaculate and you're not on this shithole website.
he's a pirate. he's exiled from fictional italy. he's a theater kid. his best friend has anxiety and lives in a suitcase. he's wanted by the catholic church for being too silly. he calls you "my dear boy." he was banished for being a fool and decided to start a circus called the troupe of fools. his main mode of transportation is a turtle. he dual wields pistols and a sword. he has beef with a giant whale. he lives on the ocean and has fire powers.
i havenât seen anyone talk about the outfit descriptions in wuwa and i honestly donât know if theyâve always been there or if thatâs new bc outfits are a thing in the game now
BUT LIKE
who wrote these ????????
rovers is so borderline passive aggressive that every time i look at it i giggle
also. did that line single-handedly make the fact that rover doesnât ever change clothes canon within the story?
mortefiâs only has one line thatâs actually about the outfit (same goes for like half the characters). but we know damn well that most of the academy researchers are NOT dressed like him and thatâs all you had to say pertaining to his outfit ????
some of the funniest ones are like baizhiâs where they try and convince you the outfit is practical. like noâŠ.itâs notâŠ
you have her fighting tacet discords in a mini bodycon dressâŠ.
shout out to yuanwu for having a description that is genuinely (mostly) just about the outfit
and then shout out to aalto and youhuâs outfit descriptions for having absolutely NOTHING to do with their clothes
âRed is Carlottaâs color.â
butâŠ
âŠpinkâŠ?
her outfit is pinkâŠ.
i can forgive that solely for for the laugh i had when reading that last line because i refuse to accept that they wrote that unironically
Hear my random thought, imagine that the PIDW fandom actually start noticing the weirdo called Peerless Cucumber and they find his comments absolutely hilarious, like âthis dude is crazy but hes damn funny tooâ and they just start teasing him with things like âwhat are you, Luo Bingheâs wife to defend him like this?â until someone actually makes a full 20.000 word fanfiction about peerless cucumber dying and reincarnating in PIDW and ending up rizzing up Luo Binghe, convincing him to leave his harem for him and they marry and live happily ever after and everyone finds this EVEN MORE HILARIOUS and more people start writing fanfic about it.
Before PIDW ends, the ship tag is one of the top 5 of the fandom in ao3 and they have tons of fanart and even an animation video on youtube that has hundreds of thousands of views and obviously airplane had seen it, and he found it hilarious too.
So when he finished PIDW he made some specials and he decided to be the funniest man ever and write one where peerless cucumber died and reincarnated in a male demon whom happened to be working close to Luo Binghe, and that was the first and last gay chapter of PIDW.
The fandom EXPLODED when they read this and the ship tag quickly became number 1 on the fandom in ao3, fanfiction.net, wattpad and tumblr.
Sadly, peerless cucumber stopped his activities on social media as soon as the final chapter of PIDW dropped, wonder what happened to that guy...
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it is currently 3am, no one can judge me for this thanks goodbye
prguitarman
kianamaiart
snowghoul
romaincrisis
gummygunk
yousharknotpass
vaporwave
andulkaphoto
