Mads Is My Whole Life

[mad-about-mads]

@luluuxoxo @hello-again-mysecretunivers-blog @randomkpopmemes 

Louis Vuitton only offers one-day discount. Please click the link for details

[mad-about-mads]

@usov-keks @morebaek4me @oohziminyeah @00--toofasttolive-tooyoungtodie @icantbelieveitsbrigi @beavoice-notanecho1d @luhannie-therain-is-suits-you @rairitiee @qpfail @homo-seoul @mireke13 @ulzzangjongin @peckhyeonnie @cryptiddy888 @whitecrow96 @damianwinsflawlessvictory @a-lazy-stalker @gittydakitty @fuckyeahritaora @ab-style-panda 

Louis Vuitton only offers one-day discount. Please click the link for details

[mad-about-mads]

@artyom-dzenkevichvpym @magnificenttimetravelavenue @femme-aphrodite @shawolwithapen @tiaoh19-blog @tianstone @jinkisymptoms @sherlockstyles @damnthestarss @jumponew @bomslegs-blog @saranghaeyo-scenarios @geguma96 @zicosaegyo-blog @hyacen @minhobooty @introducingjeudy @haechanites @elrarose @baesmin 

Louis Vuitton only offers one-day discount. Please click the link for details

[mad-about-mads]

@eixbfj1994 @silverpetalinterior @rikooooo-blog1 @i-am-emm @jelybeanssassypants @waytooshy @opie6900 @toneymike-blog1 @overdosedetoddynho @karamba000 @googame @kjaerestemin @twinklingpaopu @highlord-tarquin @avidreadr2004 @worriedshoes @fanfictionobsessednerd @xisloanfo-blog @moonlightreina-blog @camelcipv 

Louis Vuitton only offers one-day discount. Please click the link for details

[urfavhatesterfs]

YOU hates terfs

[switchingtogeico]

[captainhaterade]

[stankpasta]

rb if u hates terfs

[perkamentus]

JESSIE MEI LI ph. Wolf Marloh

[neurosciencestuff]

Simple sugar found in human breast milk possible therapy for repairing myelin in multiple sclerosis

N-acetylglucosamine, a simple sugar found in human breast milk and sold as an over-the-counter dietary supplement in the United States, promotes myelin repair in mouse models and correlates with myelination levels in multiple sclerosis patients according to a new University of California, Irvine-led study.

(Image caption: Shown are brains of newborn mice treated with or without N-acetylglucosamine by providing their nursing mothers with N-acetylglucosamine in their drinking water. Secreted in breast milk, N-acetylglucosamine entered the brain of nursing mice and stimulated myelin stem cells to promote myelination as measured by increased levels of staining (green) for both myelin basic protein and myelin (fluoromyelin). Credit: UCI School of Medicine)

Published in the Journal of Biological Chemistry, the study also demonstrates that in mice, delivering N-acetylglucosamine orally to lactating mothers drove primary myelination in their nursing offspring. N-acetylglucosamine is a simple sugar that is metabolically attached to proteins at the cell surface to control cellular function.

“We found that N-acetylglucosamine activates myelin stem cells to promote primary myelination and myelin repair,” said Michael Demetriou, MD, PhD, FRCP(C), professor of neurology, microbiology and molecular genetics at UCI School of Medicine and leader of the study. “Our data raises the intriguing possibility that N-acetylglucosamine may be a simple therapy to promote myelin repair in multiple sclerosis patients”. Formal human studies will be required to test this theory.

The failure of robust re-myelination following inflammatory demyelination in multiple sclerosis leads to chronic disability and neurodegeneration. Myelin insulates the long, cable-like nerve cell branches called axons, and serves to increase the speed of electrical signal conduction between neurons. Myelination in the central nervous system also plays an important role in cognitive development during childhood.

“Interestingly, since N-acetylglucosamine is a major component of human breast milk but not baby formula, it may explain some of the cognitive function and myelination benefits realized by children fed breast milk as opposed to formula.” said Michael Sy, MD, PhD, assistant professor of neurology at UCI School of Medicine, co-director of the regional MS program at the VA Long Beach Healthcare System, and first author of the study.

Dr. med. Alexander Brandt, MD, who led the clinical parts of the study together with Dr. med. Friedemann Paul, MD, added, “The association of reduced N-acetylglucosamine serum levels with white matter changes in the brain of patients with multiple sclerosis suggests that N-acetyglucosamine deficiency may contribute to disease severity.” At the time of the study, Brandt has been the head of the Translational Neuroimaging laboratory in the Clinical Neuroimmunology group at Charité – Universitätsmedizin Berlin, which is led by Paul. Brandt has since transitioned to the UCI School of Medicine as associate professor of neurology.

Formal clinical trials are required to test the applications identified in this study and are currently being pursued by the investigators.

[latinaspeak-blog]

Latinx women are breathtaking. Latinx women deserve to be treated like human beings because we are. Latinx women are so capable and strong and intelligent and amazing. Latinx women have come so far and deserve so much more. Latinx women deserve to be happy, healthy, and safe. Latinx women are multitalented and giving and we don’t hear it enough. Latinx women have broken barriers, can break barriers, and will break barriers. Latinx women are so precious. Latinx women are allowed to cry and have feelings and feel sad. Latinx women need to be treated with more respect. Latinx women deserve the world. Latinx women must be respected at all times. Latinx women are hardworking and discredited. Latinx women stand together and call out abuse. Latinx women are humans. Latinx women are deserving and great. Latinx women face so much adversity and don’t deserve the hatred they face. Latinx women are allowed to feel angry without people fetishizing their anger. Latinx women are deserving of life and respect no matter where they were born. Latinx women are not creatures, but humans. Latinx women are not spices, but humans. Latinx women are allowed to speak out against things that are unjust. Latinx women need more representation in the media. Latinx women come in all colors, shapes, sizes, and from all over the world. Latinx women speak any language. Latinx women are introverted or extroverted or ambiverts. Latinxs women are allowed to be shy or outgoing. Latinx women are doctors, lawyers, stay at home mothers, teachers, janitors, chefs, cashiers, hairstylists, dancers, politicians, sex workers, accountants, vets, dentists, volunteers, artists, public speakers, managers, therapists, nannies, models, writers, athletes- everything and all deserving of the utmost respect. Latinx women own their own bodies and are in control of their own lives. Latinx women love. Latinx women are allowed to feel numb. Latinx women are revolutionary. Latinx women are, but not limited to, bisexual, pansexual, lesbian, unsure, trans, asexual- unending. Latinx women are Muslim, Jewish, Christian, Buddhist, Atheistic, Agnostic, Pagan and more. Latinx women do not deserve to be fetishized. Latinx women are humans, not sex objects. Latinx women are allowed to struggle with physical, mental, and developmental illnesses. Latinx women are survivors. Latinx women are warriors. Latinx women are allowed to laugh and cry. Latinx women are allowed to rest. Latinx women are so much more than what is written in this post. Latinx women deserve justice. Latinx women deserve to not be spoken over. Latinx women deserve positivity. Latinx women deserve to not have their issues derailed or ignored. Latinx women are so beautiful.

[imagineredwood]

🗣🗣🗣

[shadowandbone]

KAZ & INEJ Season 1, Episode 7

[evermore-fashion]

Ziad Nakad ‘The Snow Crystal Forest’ Fall 2017 Haute Couture Collection

[toastbutteregg]

[shadowandbonedaily]

Amita Suman for Euphoriazine (x).

[oldfarmhousefallfeatures]

traditional and authentic 1893 farmhouse kitchen

.https://www.instagram.com/bryartonfarm

[losaslut]

Gino Vento as Nestor Oceteva in Mayans MC Season 3 Episode 8 (ft his glorious mane)

[princesshamlet-deactivated20210]

as a jew i love having opinions on jesus. it’s like. no i don’t think he was messiah However Yes i am a fan of this dude. fucker said ‘it’s easier for a camel to go thru the eye of a needle than it is for a rich man to go to heaven’ and proved his point by going absolutely ballistic flipping tables and chasing merchants with a whip in broad daylight in a synagogue. basically my thoughts on jesus are: 10/10 would go to brunch with.

[beggars-opera]

[prophecysgirl]

Olivia Baker in All American 3.10 Put Up or Shut Up

[oldfarmhousefallfeatures]

Incredibly beautiful.

This is New England Living Folks

Photocredit :#Dirtanglass @instagram