Drug Treatment for Depression
The use of drugs to treat unipolar depression is based on the biological explanation for depression, the monoamine hypothesis. They work by increasing levels of monoamines, namely serotonin, which helps regulate levels of other important mood-related monoamines. There are many different types of anti-depressant, although some are more effective than others. Here are some examples of types of anit-depressant drugs:
monoamine oxidase inhibitors (MAOI’s) work by temporarily inhibiting monoamine oxidase, the enzyme that breaks down the monoamines, helping them to stay in the body longer so they can continue working
selective serotonin reuptake inhibitors (SSRI’s) work by blocking reuptake of serotonin so it stays in the body longer
atypical drugs target noradrenaline and dopamine levels as well as serotonin
None of the above drugs are completely free from side effects (which include, nausea, dizziness, weight gain, insomnia, headaches and fatigue) although newer drugs do have less; MAOI’s were the first anti-depressant drugs created, so they have severe side effects and need dietary restrictions in order to work, therefore only used as a last resort. Patients can become reliant on anti-depressant drugs in order to function, so when a patient stops taking them, the amount they take each day must slowly be reduced so that their body can become accustomed to functioning without the drug.
Drug treatment is supported by Kuyken et al’s (2008) findings, which showed anti-depressants to be effective at treating depression and preventing relapse across an eight week trial when compared to CBT. Drugs are useful for temporarily boosting the mood of severely depressed patients in order for them to attend other therapies like CBT. Plus, researchers are continuously investigating possible new anti-depressants with even fewer side effects than existing drugs.
However, a 2006 government study showed that only 50% of those who take anti-depressants become symptom free, with many relapsing despite continuously taking the medication. Anti-depressants are not a long term solution or cure to depression, as they only help to ease symptoms and are not effective unless a patient is taking them regularly. They also cause unpleasant withdrawal symptoms when a patient must stop taking them.


















