If You Like Mass Effect, Try...
Saints Row IV | Why: space romance ship, keith david, humor
Deus Ex Series | Why: RPG with FPS elements & choice based gameplay
Knights of the Old Republic 1 & 2 | Why: Bioware game, space
Dragon Age Series | Why: Bioware game
Bioshock Series | Why: Tone, extraordinarity abilities, sci-fi
Nomad Fleet | Why: MCs like Quarians, villains like Reapers
Dead Space Series | Why: space, horror elements
The Witcher Series | Why: RPG, heavy storytelling, great plot points
No Man’s Sky | Why: exploration, space
Destiny | Why: space, extraordinary abilities
The Solus Project | Why: exploration, story focus, lore
Technomancer | Why: Similar tone
Star Control 2 | Why: Space opera, similar plot
Halo 1 - 3 | Why: similar tone, sci-fi, combat
Traveller (Tabletop Game) | Why: weapons, aliens, d&d elements
Firefly | Why: similar tone, character focus, space opera [see also: Serenity in Movies section]
Stranger Things | Why: 80s inspired, simliar music
Killjoys | Why: lore, science, sci-fi, space, villains named “Reapers”
The Expanse | Why: space, space opera, shared actor
Farscape | Why: tone, space, aliens
Cowboy Bebop | Why: space, visuals, tone, character focus
Outlaw Star | Why: space, tone
Tengen Toppa Gurren Lagann | Why: similar villains
Stargate: Atlantis | Why: aliens, similar technologies, moral dilemmas
Battlestar Galactica (2004) | Why: robots, tone, shared actor
Babylon 5 | Why: aliens, extraordinary abilities, tone, humor, plot
Futurama | Why: parodies sci-fi tropes
Star Trek | Why: character focus, space, moral dilemmas, plot [see also: Star Trek in Movies section]
Star Trek The Next Generation
Star Trek Deep Space Nine
Titan AE | Why: tone, visuals, aliens
Blade Runner | Why: 80s, visuals, robots
Guardians of the Galaxy | Why: humor, visuals
Alien & Aliens | Why: strong female lead, visual, space, aliens
Prometheus | Why: visual, space, aliens, exploration
Fifth Element | Why: space opera, visuals
District 9 | Why: aliens, moral dilemmas
Treasure Planet | Why: space, aliens, exploration
Star Trek Series (2009-Present) | Why: character focus, space, moral dilemmas, plot [see also: Star Trek in TV section]
Serenity | Why: similar tone, character focus, space opera [see also Firefly in TV section]
Saga | Why: tone, character focus, space opera
Lost Fleet Series | Why: space opera, strong female lead
The Confederation Series | Why: aliens, strong female lead
Hitchhikers Guide to the Galaxy Series | Why: exploration, space, aliens
The Expanse Series | Why: soap opera, space
The Martian | Why: humor, MC similar to Shepard
The Wayfarers Series | Why: spaceship, diverse crew, aliens, robots
Kris Longknife Series | Why: space opera, strong female lead
Paradox Trilogy | Why: aliens, romance, adventure, strong female lead
The Succession Series | Why: sci-fi, similar characters