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[drawittoknowitmedical]

Here's the answer to our Histology Quiz Question from earlier today!

[researchchla]

A Higher Resolution Image of Human Lung Development

The invention of interactive map applications has revolutionized wayfinding, providing an unprecedented level of information far beyond what printed road maps can offer. Researchers at Children’s Hospital Los Angeles are giving us a similar look into the anatomy of the human lung, and their findings could help babies breathe easier.

Infants born prematurely often suffer from poor lung development and can face life-threatening consequences. In order to provide novel treatments for these babies, we must first understand how cells of the lung differentiate and grow. But there are large knowledge gaps that must first be filled. Denise Al Alam, PhD, leads a team that studies development of the lung on a molecular and cellular level.

A new study, published online in European Respiratory Journal, marks an important milestone. “This is one of the very first studies looking at how the human lung develops at the single cell level,” says Dr. Al Alam. The study tracked the fate of these cells over time, showing a trajectory of cell development. Knowing when certain cell types are differentiating gives investigators a very detailed, time-lapse map to lung development.

Dr. Al Alam’s team focused on the development of two types of cells in the lung. Airway smooth muscle cells line structures such as the trachea, bronchial tubes, and smaller branches. Vascular smooth muscle cells are found in the walls of blood vessels. Both types of cells add muscle tone and stability while also mediating necessary movement within these structures. But they are often implicated in different disease pathways.

“The problem is that we can never really study one cell type without also studying the other,” says Dr. Al Alam, investigator in the Developmental Biology and Regenerative Medicine Program at The Saban Research Institute of CHLA. Up until now, investigators have used a marker – known as ACTA2 – to identify these cells. But the marker doesn’t distinguish between the two smooth muscle cell types. Although both types of cells are smooth muscle they are implicated in totally different pulmonary diseases. “We need to study the two types of cells independently to understand what happens in different lung disorders.” Fortunately, her work has solved this problem that has hindered research in the field.

Dr. Al Alam’s team has identified molecular markers that are unique to each subset of cells. This will allow investigators to differentiate between the two groups, which will benefit respiratory research efforts worldwide. Developmental disorders such as COPD, asthma, and bronchopulmonary dysplasia can now be studied separately from related, but distinct, conditions that arise later in life, such as pulmonary hypertension.

“It’s been decades since we’ve introduced anything into the clinic to treat lung diseases associated with prematurity,” says Dr. Al Alam. “We are putting together critical pieces so we can get these babies the treatments they need.”

The first author of the study was Soula Danopoulos, of The Saban Research Institute of CHLA. Other authors on the study were Soumyaroop Ghattacharya and Thomas J Mariani of the University of Rochester. The study was funded by the National Institutes of Health National Heart, Lung, and Blood Institute (R01HL141856, R01 DA037447) and the Hastings Center for Pulminary Research.

[doctordconline-blog]

How important do you think about anatomy in medicine ? Don't forget to revise anatomy if you get chance. @@@ Let's refresh our anatomy , share and tag friends @@@@@@ #anatomylove #revision #letsrefresh #anatomy #physiology #basicscience #usmle #usmlestep1 #usmlestep2 #university #pathology #orthopedics #orthopedicsurgeon #doctor #doctordconline #nhs #nurse #nursing #hospital #patient #medicine #medstudent #amc #plab @doctordconline

[totalhealthperformance]

#Repost @oldschoolworkout with @let.repost • • • • • • Understand the basics first... #charlespoliquin #poliquin #basicscience #trainingmethods #trainingprinciples #bodybuildingscience #sportshistory #strengthhistory #historyofbodybuilding #sciencebasedtraining #poliquingroup #strength #strengthandconditioning #armsgains #bicepgains #gainz💪 #bicepworkout #armsday #armstrength #musclegains #weightgain #oldschooltraining #musclescience #trainingscience #oldschoolstrength #bodybuildingbasics (at THP - Total Health Performance) https://www.instagram.com/p/CoQFnKtvl9o/?igshid=NGJjMDIxMWI=

[foodhealthsolutions]

Biochemical and nutritional profile of maize bran‐enriched flour in relation to its end‐use quality

Maize bran‐enriched flour is rich source of nutritional and bioactive components. Maize bran‐enriched flour bread has high dietary fibers than wheat flour bread. MB‐enriched flour bread explicated high score of sensorial overall acceptability.

Abstract

The core objective of current research was determined to nutritional and bioactive profile of maize bran (MB)‐enriched flour in relation to its end‐use product quality. Furthermore, rheological properties of MB‐enriched flour at different levels (5%, 10%, and 15%) were explicated through farinograph and mixograph. Moreover, bread was prepared with the addition of MB‐enriched flour and was characterized for nutritional and textural properties. Results showed that MB‐enriched flour having high water absorption and water retaining potential up to 4%–7% as compared to wheat flour (WF). Moreover, dough height gradually decreased with the addition of MB due to water‐binding ability of bran which causes a decrease in gas retention during fermentation. This resulted in bread volume decrease (4%–7%) as compared to WF. Furthermore, the moisture content and hardness increased with the addition of MB. The water activity of bread slightly increased with the addition of maize bran after 4‐day storage. Conclusively, MB‐enriched flour improved nutritional, textural, and sensorial properties of final product.

By: Muzzamal Hussain, Farhan Saeed, Bushra Niaz, Muhammad Afzaal, Ali Ikram, Shahzad Hussain, Abdellatif A. Mohamed, Mohamed S. Alamri, Faqir M. Anjum Title: Biochemical and nutritional profile of maize bran‐enriched flour in relation to its end‐use quality Sourced From: onlinelibrary.wiley.com/doi/10.1002/fsn3.2323?af=R Published Date: Tue, 04 May 2021 01:05:03 -0700

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[foodhealthsolutions]

Application of ε‐polylysine in extending the storage period of pork jerky

ε‐Polylysine has excellent antimicrobial activity and quality stability. ε‐Polylysine can extend the storage period of pork jerky to 180 days. ε‐Polylysine has a high research value in meat jerky and other products.

Abstract

In this experiment, natural nontoxic preservative ε‐polylysine (ε‐PL) was used as a natural preservative in pork jerky. The pork jerky samples with ε‐PL (experimental group) and without ε‐PL (blank group) were stored at the 27 and 37℃. Then, the number of microorganisms, total volatile basic nitrogen (TVB‐N), pH, and water activity (Aw) of each group were tested to test the antiseptic effect of ε‐PL. The results showed that due to the Staphylococcus aureus was detected, the storage period of the blank group at 27 and 37°C was 15 and 9 days, respectively. However, Coliforms, Staphylococcus aureus, Salmonella, and Shigella were not detected in the experimental group on the 60th day. The experimental group all accord with the national standard for the quantity of microorganisms in meat jerky. The TVB‐N content of the blank group reached 14.00 mg/100 g (15th day, 27°C) and 14.93 mg/100 g (9th day, 37°C) at the end of the storage period, while the TVB‐N content of the experimental group was 11.20 mg/100 g (60th day, 27℃) and 15.86 mg/100 g (60th day, 37℃), and the increase rate of TVB‐N in the blank group was greater than the experimental group, indicating that ε‐PL can play a better microbial stabilization effect in pork jerky. The test of pH and Aw showed that ε‐PL can stabilize the quality of pork jerky. Finally, the antiseptic effect of ε‐PL was comparable to many chemical preservatives. This experiment confirms that ε‐PL played an important role in extending the storage period of pork jerky.

By: Yizhuo Zhang, Changqing Zhao, Xingxiu Zhao, Yiguo He Title: Application of ε‐polylysine in extending the storage period of pork jerky Sourced From: onlinelibrary.wiley.com/doi/10.1002/fsn3.2289?af=R Published Date: Tue, 04 May 2021 00:30:02 -0700

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[dailymaterial]

#Dailymaterials #DailyStudy #DailyFact #BasicScience #ScienceNotes #DailyNotes https://www.instagram.com/p/BzvHDfaFJnY/?igshid=ndzh99pb51gl

[mydencyclopedia-blog]

The Anatomical Basis of Dentistry

The Anatomical Basis of Dentistry

Author: Bernard Liebgott Edition: 3rd Edition

Download The Anatomical Basis of Dentistry

  The 1/3 edition of The Anatomical foundation of Dentistry maintains to meet the need for a textbook of gross anatomy especially written for the dental profession. but some other version, but, begs the question, “How has the have a look at of anatomy modified because the final version of the book?” Human gross anatomy has no longer modified substantially over the centuries. However the strategies of describing, illustrating, and imparting the material have changed substantially and maintain to change.  In addition, the advent of scientific relevance has converted the take a look at of anatomy from an insufferable mandatory first-12 months hurdle to a significant revel in on which to build a a success profession in the exercise of dentistry. The answer is that, as dental professionals, we're licensed to write down prescriptions, take and interpret radiographs, administer anesthesia (neighborhood and general), and perform orofacial surgical methods. Moreover, no matter scientific histories and essential precautions, headaches can get up during routine treatment. Prevention and treatment of headaches require sound background information (of the form and characteristic) of the human frame that transcends a basic knowledge of the dental arches.

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