Discover Top Posts Tagged with #brain tumor

He finally told her... Mark can’t hide it anymore and tells Amber everything.

COUNTDOWN - S1.E7 / Nothing Else Helps!

#heartbreaking #jensen ackles #mark meachum #moment of truth #amber oliveras #brain tumor #countdown

getting a little personal

I had a whole big description that i copy/pasted on insta and tiktok but it already cleared out of my clipboard so idccccc

its been a rough ass year, ive mostly only mentioned that here but its my terrible mental state and i get to make art about it

have a good evening yall, remember to always take care of yourself. brain health and hormonal health are so important

#digital arwork #digital aritst #art #comic #personal comic #brain tumor #brain health #hormonalhealth #please please let this be a heads up to always take care of yourself #im so lucky #im so unbelievably lucky #it was growing really fast #but since we caught it so early #it didnt grow large enough to require surgery #only medication thankfully #and the meds SUCK but i didnt have to go blind before getting medical attention #when your body tells you something is wrong please listen

Please check out my go fund me.

#go fund me #brain tumor

Flag for people with brain injuries!

#my hoard #my creations #flag creation #brain injury #acquired brain injury #traumatic brain injury #neurodegenerative diseases #cerebral palsy #brain tumor #brain infections #hypoxia #contusion #post concussion syndrome #parkinsons #intracranial hemorrhage #etc #disability pride flag

Moodboard for Scratch (The Amazing Digital Circus) golden retrievers/brain tumor/programming/circus/desire to live quotes/yellow/red themes For an anon! Hope you enjoy ^^

We're closed for now, thank you!!

In the first human trial, an mRNA cancer vaccine at the University of Florida triggered immune systems to fiercely attack glioblastoma.

"In a first-ever human clinical trial, an mRNA cancer vaccine developed at the University of Florida successfully reprogrammed patients’ immune systems to fiercely attack glioblastoma, the most aggressive and lethal brain tumor.

The results in four adult patients mirrored those in 10 pet dog patients suffering from brain tumors whose owners approved of their participation.

The discovery represents a potential new way to recruit the immune system to fight treatment-resistant cancers using an iteration of mRNA technology and lipid nanoparticles, similar to COVID-19 vaccines, but with two key differences: use of a patient’s own tumor cells to create a personalized vaccine, and a newly engineered complex delivery mechanism within the vaccine.

“Instead of us injecting single particles, we’re injecting clusters of particles that are wrapping around each other like onions,” said senior author Elias Sayour, M.D., Ph.D., a UF Health pediatric oncologist who pioneered the new vaccine, which like other immunotherapies attempts to “educate” the immune system that a tumor is foreign.

“These clusters alert the immune system in a much more profound way than single particles would.”

Among the most impressive findings was how quickly the new method spurred a vigorous immune-system response to reject the tumor, said Sayour, principal investigator at the University’s RNA Engineering Laboratory and McKnight Brain Institute investigator who led the multi-institution research team.

“In less than 48 hours, we could see these tumors shifting from what we refer to as ‘cold’—very few immune cells, very silenced immune response—to ‘hot,’ very active immune response,” he said.

“That was very surprising given how quick this happened, and what that told us is we were able to activate the early part of the immune system very rapidly against these cancers, and that’s critical to unlock the later effects of the immune response,” he explained in a video (below).

Glioblastoma is among the most devastating diagnoses, with median survival around 15 months. Current standard of care involves surgery, radiation and some combination of chemotherapy.

The new report, published May 1 in the journal Cell, is the culmination of seven years of promising studies, starting in preclinical mouse models.

In the cohort of four patients, genetic material called RNA was extracted from each patient’s own surgically removed tumor, and then messenger RNA (mRNA)—the blueprint of what is inside every cell, including tumor cells—was amplified and wrapped in the newly designed high-tech packaging of biocompatible lipid nanoparticles, to make tumor cells “look” like a dangerous virus when reinjected into the bloodstream to prompt an immune-system response.

The vaccine was personalized to each patient with a goal of getting the most out of their unique immune system...

While too early in the trial to assess the clinical effects of the vaccine, the patients either lived disease-free longer than expected or survived longer than expected. The 10 pet dogs lived a median of 4.5 months, compared with a median survival of 30-60 days typical for dogs with the condition.

The next step, with support from the Food and Drug Administration and the CureSearch for Children’s Cancer foundation, will be an expanded Phase I clinical trial to include up to 24 adult and pediatric patients to validate the findings. Once an optimal and safe dose is confirmed, an estimated 25 children would participate in Phase 2."

-via Good News Network, May 11, 2024

-video via University of Florida Health, May 1, 2024