#cellular replication

[medicomunicare]

Striatum and cerebellum as related and damaged partners in Huntington's disease: a matter of vulnerability

In patients with Huntington’s disease, neurons in a part of the brain called the striatum are among the hardest-hit. Degeneration of these neurons contributes to patients’ loss of motor control, which is one of the major hallmarks of the disease. As many as 10 years ahead of the motor diagnosis, Huntington’s patients can experience mood disorders, and one possibility is that the striosomes might…

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[medicomunicare]

Clinical trials for hormone-positive resistant breast cancer: exploring kinase inhibitors and ER-modulators

Clinical trials for hormone-positive resistant breast cancer: exploring kinase inhibitors and ER-modulators

Patients with hormone receptor (ER)-positive, growth factor receptor (Her2)-negative breast cancer are commonly treated in the first line with an endocrine therapy (such as an aromatase inhibitor like anastrozole, which blocks the production of estrogens) alongside a CDK4/6 inhibitor, which stalls the cell cycle. Eventually, however, most tumors develop resistance to these therapies, and options…

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[medicomunicare]

Anticancer weaponry upgraded: the more the knowledge below, the more specific the payload

Anticancer weaponry upgraded: the more the knowledge below, the more specific the payload

Although advances in chemotherapy over the past 20 years have led to better survival of patients with various forms of cancer, the continuing biological evolution of drug-driven tumors leads to the breakdown of resistant forms with the consequent possibility of therapeutic failures. This is why the continuous development of new categories of drugs is necessary to overcome the problem. A study in…

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[medicomunicare]

Together is better than alone: did you put a Notch in your belt to remember it?

Together is better than alone: did you put a Notch in your belt to remember it?

Australian scientists have found a new and effective way to treat a particularly aggressive blood cancer in children. Acute lymphoblastic leukemia (ALL) is the most common cancer diagnosed in kids. Despite dramatic improvements in the survival of children with ALL over past several decades, children who develop ‘high risk’ ALL – subtypes that grow aggressively and are often resistant to standard…

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[medicomunicare]

Prostate cancer: when a single aminoacid makes the difference between "stasis" and metastasis

Prostate cancer: when a single aminoacid makes the difference between “stasis” and metastasis

An increased awareness on a molecular level of what mechanisms prostate cancer cells use to become mobile and start spreading may in the long run provide new opportunities for treatment of aggressive prostate cancer. This according to a new study by researchers at Umeå University, Sweden, in collaboration with researchers in Uppsala and Tokyo. This research has studied the growth factor TGF-β, or…

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[medicomunicare]

Dealing with the "hammer to fall": a precise target to be struck for an optimal cell killing

Dealing with the “hammer to fall”: a precise target to be struck for an optimal cell killing

Lung cancer accounts for a quarter of all cancer deaths, and non-small cell lung cancer makes up 84% of all lung cancer cases. Targeted therapies can be effective for a time against selected lung cancers, but resistance to these therapies soon develops. A cancer cell is like a small factory with many moving parts working towards one common goal: survival and reproduction of the tumor at the…

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[medicomunicare]

Lesch-Nyan gets nucleo-tide: too musch folate in culture has simply hidden the understanding beneath

Lesch-Nyan gets nucleo-tide: too musch folate in culture has simply hidden the understanding beneath

Lesch-Nyhan is a rare genetic neurological disease, affecting 1 in 380,000 newborns. Patients suffer from overproduction of uric acid, anemia, severe neurological problems, and compulsive self-injurious behavior. The pathology is caused by a deficiency of HGPRT, an enzyme that participates in the metabolism of purine nucleotides. Purines regulate many biological processes and are part of the…

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[eideard]

Scientists hold private discussion about creating synthetic DNA

Scientists hold private discussion about creating synthetic DNA

This was published a few days after the meeting ❝ Scientists are now contemplating the fabrication of a human genome, meaning they would use chemicals to manufacture all the DNA contained in human chromosomes. The prospect is spurring both intrigue and concern in the life sciences community because it might be possible, such as through cloning, to use a synthetic genome to create human beings…

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