#circadian clock

[chronicillnessresourcelibrary]

Chronic Illness News from the Past Week

📰 A miniature injectable device is being developed that will help treat chronic pain and movement disorders. Revolutionizing implant technology, this new device is the size of a seed and powered wirelessly, thus eliminating the need for batteries, wires, and surgery!

📰 A new study found that people with celiac disease showed consistent differences in immune cell function. There even appear to be differences in immune system functions before symptoms develop. The researchers hope these findings will lead to more personalised monitoring and better care in the future.

📰 Researchers from Radboud University Medical Center have developed a new test that is better able to diagnose rare genetic disorders, provides a much more complete picture of DNA, and can replace fifteen other tests!

📰 Scientists may have figured out a way to regrow worn-out joint cartilage! This could be a game-changer for people with cartilage damage from aging or arthritis, and could even eliminate the need for knee and hip replacement surgeries in the future.

📰 Researchers at Kyushu University have discovered that the circadian clock may be linked to inflammatory responses in immune cells. These findings could improve treatmeants for inflammatory diseases and cancer as they indicate that giving anti-inflammatory drugs at a particular time of day could enhance treatment efficacy and minimize side effects.

📰 Good news for people with Sjögren's disease – a recent study has advanced understanding of how the disease progresses! This new development could help researchers develop more targeted treatments in the future instead of relying on broad immunosuppressive drugs that work on the entire immune system.

[violet-phoenix-nebula]

Well, I just took a truly obnoxious amount of melatonin. Time to see what happens.

[sijuikabisa]

[neurosciencenews]

Scientists Assemble a Biological Clock in a Test Tube to Study How It Works

A reconstituted circadian clock of cyanobacteria can run for consistent days, allowing researchers to study the interactions of the clock proteins in real-time and observe how the clock exerts control over gene expression.

[mindblowingscience]

In First-of-Its-Kind Discovery, Scientists Confirm Bacteria Have a 24-Hour Body Clock

"They adapt their molecular workings to the time of day by reading the cycles in the light or in the temperature environment."

In a first-of-its-kind discovery, scientists have found that a species of non-photosynthetic bacteria are regulated by the same circadian rhythms that hold sway over so many other life-forms.

In humans, our circadian rhythms act as a kind of biological clock in our cells, controlling virtually all the processes in our bodies, influencing when we sleep and rise, plus the functioning of our metabolism, and cognitive processes.

This internal time-keeping, which revolves around a 24-hour cycle, is driven by our circadian clock, and the same core phenomenon has been observed in many other kinds of organisms as well, including animals, plants, and fungi.

For a long time, however, it's been unclear whether bacteria at large are also subject to the dictates of circadian rhythms.

Continue Reading.

[pagingdredgware]

so rip dr edgware's circadian rhythms productivity recharge time

[bpod-bpod]

Treatment Time

No matter how hectic your lifestyle, the body naturally tries to run on a roughly 24-hour cycle. That’s why jet lag leaves you feeling so off. The body adapts fairly quickly after a single trip, but regular disruption, such as for shift work, can have lasting effects on health, raising the risk of brain disorders such as Alzheimer’s disease. A new study might help explain why this is. Investigating the area of the brain that keeps the cycle in time it found that one protein called CDK5 interacts with another called PER2 (green and red in the mouse cells pictured), levels of which rise and fall as the brain keeps time. Tweaking CDK5 levels adjusted mouse circadian rhythms, as did removing PER2, suggesting CDK5 regulates PER2’s activity. CDK5 has previously been linked to various neurological disorders. Could it one day be used to manipulate our body clock and treat patients?

Written by Anthony Lewis

Image by Andrea Brenna and Iwona Olejniczak

Department of Biology, University of Fribourg, Fribourg, Switzerland

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, November 2019

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[currentsinbiology]

Daytime wounds heal more quickly than those suffered at night 

The antidote to a bad scrape-up is usually a fairly simple recipe: antibiotics, bandages, and time. Now, a new study suggests that timing also matters. Skin cells that help patch up wounds work more quickly in the daytime than they do at night, thanks to the workings of our circadian clock. The finding suggests patients might recover from injury more quickly if they have surgery during the right time of day.