One good way to attract fruit flies into your bathroom, of all places: Bandages with manuka honey in the trash! 😧
I felt like a dumbass, taking that long to figure out what might be drawing them in there. (Seeing some congregating around the trash can kinda helped, a little while ago.) But, it's really not much honey, and I haven't even been thinking of it as food in that context. ¯\_(ツ)_/¯
Guess I'll try closing that up well in plastic bags, besides making sure it's emptied more often for a while.
Calendula officinalis (pot marigold, ruddles, common marigold)
garden marigold, English marigold, or Scottish marigold) Caléndula, Fleur de Calendule, Gold-Bloom, Holligold
“is a plant in the genus Calendula of the family Asteraceae. It is probably native to southern Europe, though its long history of cultivation makes its precise origin unknown, and it may possibly be of garden origin. It is also widely naturalised further north in Europe (north to southern England) and elsewhere in warm temperate regions of the world.
Calendula officinalis is a short-lived aromatic herbaceous perennial.The leaves are oblong-lanceolate. The inflorescences are yellow, comprising a thick capitulum or flowerhead 4–7 cm diameter surrounded by two rows of hairy bracts; in the wild plant they have a single ring of ray florets surrounding the central disc florets.
Pot marigold florets are edible. They are often used to add color to salads or added to dishes as a garnish and in lieu of saffron. The leaves are edible but are often not palatable. They have a history of use as a potherb and in salads.
Flowers were used in ancient Greek, Roman, Middle Eastern, and Indian cultures as a medicinal herb as well as a dye for fabrics, foods, and cosmetics. Many of these uses persist today. They are also used to make oil that protects the skin.
Marigold leaves can also be made into a poultice to helps scratches and shallow cuts to heal faster, they also when made into a poltice can help prevent infection.
Sooths exfoliative cheilitis = heavily cracked/ chapped, crusted lips/mouth corners * see research link PMC2803874/
Anti-inflammatory *see research link 19374166
Enhances wound healing and increases collagen ,reduces leg ulcers (Excerpt from:” The percentage of wound closure was 90.0% . extract treatment at a dose of 20 or 100 mg/kg “) *see research link 19601397 , 25266273, PMC3841996/, 16372475
Antioxidant *see research link /19405380, 17921550 , 12189055
Anticancer ,antitumor , anticarcinoma, anti-leukemia Orally taken 50mg/kg (Excerpt from research:” In leukemia cell lines, LACE treatment inhibited 100% of growth. The growth of Ando-2 tumor was reduced in a 60%. The anti-tumor efficiency of LACE was similar to obtained with other commonly used chemotherapy drug, paclitaxel. LACE (Laser Activated Calendula Extract ) “) *see research link PMC1513589/, 17190444
Improves radiodermatitis caused by radiation therapy *see research link 25992820, PMC3841996/
Anti-plaque & gingivitis *see research link PMC3917203/
Anti- HIV type 1 (Excerpt from research:” the organic extract from Calendula officinalis flowers caused a significant dose- and time-dependent reduction of HIV-1 reverse transcription (RT) activity. “) *see research link 9207986
Can relax and induce cramps * see research link 16906636
Reduces ulcerative colitis *see research link 22737434, 26831607
Cardioprotective and myocardial infarct damage reducing (Excerpt from research:” Calendula achieved cardioprotection by stimulating left ventricular developed pressure and aortic flow as well as by reducing myocardial infarct size “)* see research link 20874690
Natural sunscreen ,SPF 15 * see research link PMC3326776/ , 21491442
Reduces oropharyngeal mucositis *see research link PMC3623793/
Hydroxyurea-associated Leg Ulcers in primary Myelofibrosis: A Case Presentation by Dr Vishnu Sharma by Journal of Clinical Case Reports Medical Images and Health Sciences
Abstract
Hydroxyurea, a cytotoxic agent commonly employed in the treatment of myeloproliferative disorders, has been linked to various dermatological manifestations, including the infrequent occurrence of leg ulcers. We present a case of a middle-aged male patient with a medical history of primary myelofibrosis, who presented with multiple painful leg ulcers secondary to hydroxyurea therapy. This case underscores the critical significance of comprehensive literature review and meticulous evaluation to identify and manage adverse events associated with hydroxyurea therapy.
Keywords: Myeloproliferative disorders, Leg ulcers, Hydroxyurea, Primary Myelofibrosis, Adverse drug reactions.
Case
A male patient in his 60s, who was receiving treatment for primary myelofibrosis (DIPSS Plus Intermediate-1 risk group) with hydroxyurea, presented with multiple painful ulcers located below the ankle on the medial, lateral and posterior sides of the left leg (figure 1). These ulcers exhibited ill-defined margins and showed signs of sloughing and degenerative changes at the floor. On physical examination, the ankle-brachial index was within the normal range (1; Normal range: 0.9-1.3) and pedal pulses were felt bilaterally. There were no dilated veins or pain with dorsiflexion of foot. Other common causes of leg ulcers, such as diabetes mellitus, hypertension, infectious etiologies, and autoimmune conditions, were also ruled out. A biopsy of the ulcer showed no signs of cancer. The patient's therapy also included thalidomide and amitriptyline; however, no documentation of leg ulcers caused by these medications was found.
Consequently, a decision was made to discontinue hydroxyurea, and the patient was started on ruxolitinib. After a period of 2 months following the discontinuation of hydroxyurea, a notable improvement in the ulcers was observed (figure 2), thus confirming a diagnosis of hydroxyurea-induced ulcers.
Adverse effects associated with hydroxyurea include various skin manifestations such as xerosis, nail discoloration, diffuse hyperpigmentation and skin eruptions to name a few.1
Although rare, the occurrence of leg ulceration has been documented, affecting approximately 9% of patients undergoing hydroxyurea therapy for myeloproliferative diseases.1 The mechanism is thought to be associated with the cytotoxic action of hydroxyurea on proliferating cells during the synthesis phase of the cell cycle, which may impair the synthesis of keratinocytes and collagen fibers in the skin. 1
Multiple painful ulcers located below the ankle on the left leg with ill-defined margins and signs of sloughing and degeneration
Healing observed in leg ulcers after discontinuing Hydroxyurea.
Financial disclosure statement: The authors declared that this study received no financial support.
Conflict of interest statement: No conflicts of interests were declared by the authors.
Diabetic Foot: Comprehensive Care and Treatment for Leg Ulcers
Explore the essential care required for diabetic foot complications, focusing on leg ulcers and related issues. This page covers various aspects of diabetic foot care, including wound management, vascular assessments, neuropathy treatment, and orthopedic interventions. A multidisciplinary approach ensures effective solutions to prevent and manage diabetes-related foot conditions, improving patient outcomes and quality of life.
Wounds are a common occurrence, and while many heal without complications, some persist, leading to non-healing and chronic wounds.
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Expert Care for Leg Ulcers by Dr. Sumit Kapadia: Healing Beyond the Surface
In the quest to combat leg ulcers effectively, Dr. Sumit Kapadia, a preeminent vascular surgeon in Vadodara, India, offers groundbreaking treatments and holistic care. This article delves into the types, symptoms, causes, and innovative treatments of leg ulcers, highlighting Dr. Kapadia's expertise in the field.
Understanding Leg Ulcers and Their Impact
Leg ulcers are more than just superficial wounds; they are deep sores arising from poor blood circulation or damaged veins. Typically appearing around the ankles or lower legs, these ulcers vary in size and depth, often leading to pain, swelling, and prolonged healing periods.
Types of Leg Ulcers Treated by Dr. Sumit Kapadia
Venous Ulcers: Stemming from damaged vein valves, leading to high pressure and skin breakdown.
Arterial Ulcers: Caused by poor circulation due to narrowed arteries, commonly found on the feet and toes.
Neuropathic Ulcers: Predominantly in diabetics, arising from nerve damage and loss of sensation.
Varicose Ulcers: Linked with varicose veins, due to increased pressure and blood pooling in the legs.
Identifying Symptoms for Timely Intervention
Symptoms of leg ulcers include:
Pain and discomfort around the ulcer.
Skin discoloration and texture changes.
Swelling and discharge from the ulcer.
Itching and irritation near the affected area.
Comprehensive Treatment Approaches by Dr. Kapadia
Dr. Sumit Kapadia’s treatment methodologies are multifaceted, focusing on the underlying causes and the patient’s overall health. Treatment options include:
Compression Therapy: Enhancing blood flow in venous ulcers.
Improved Circulation: Medications and interventions for arterial ulcers.
Diabetic Management: Tight control of blood sugar and wound care for diabetic ulcers.
Holistic Care and Advanced Wound Healing Techniques
Emphasizing the importance of comprehensive care, Dr. Kapadia provides advanced wound care, including Negative Pressure Wound Therapy (NPWT) and biologic or synthetic skin substitutes. His approach is not just about treating the ulcer but also about educating patients on self-care and preventive measures.
Why Dr. Sumit Kapadia Stands Out?
Personalized Care: Tailoring treatment plans to each patient's unique needs.
Expertise: Leveraging the latest advancements in vascular medicine.
Patient Empowerment: Educating and supporting patients throughout their treatment journey.
Seeking Expert Care
For those grappling with leg ulcers, timely consultation with Dr. Sumit Kapadia is crucial. His expertise in vascular health offers a path to effective healing and improved quality of life.
To schedule a consultation, contact Dr Sumit Kapadia’s team at +91 9904114443 (WhatsApp available) or visit Dr Sumit Kapadia’s website.
