#leukocytes

[er-cryptid]

Bone Marrow

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[selfsciencenotes]

Blood makeup/characteristics part 2: Buffy Coat

BUFFY COAT

(makes up less than 1% of blood)

1) Leukocytes (white blood cells) there are 5k-10k wbc in blood

-> 5 types. Listed in order of most abundant to least

i. Neutrophils

-> first on the scene and first to die. Dead neutrophils are the pus we see in wounds. They fight infections, respond to damage, viruses, bacteria. They neutralize and clean up.

ii. Lymphocytes

-> these are the B cells and T cells. The T cells include Helper T cells which activate other cells like the Cytotoxic T cells and B cells when there's an infection, Cytotoxic T cells (killer T cells) that kill infections, and regulatory T cells that reduce T cell activity to make sure the T cells don't go overboard and start attacking healthy cells. B cells include B cells that create antibodies to fight infection. The two main types are B cells that turn to plasma and create antibodies, and B memory cells that remember infections and can trigger a faster immune response to the same infection in the future.

iii. Monocytes

-> they're inactive and float in the blood vessels. When an infection occurs they move into tissues and turn to macrophages. These are wbc that are "big eaters", they eat the pathogens. They can also turn into dendrites which alert other cells to of an infection that needs fighting. They essentially call for backup.

iv. Eosinophils

-> help fight of infections caused by parasites and allergic reactions

v. Basophils

-> deal with allergens and fight parasites, bacteria, viruses, and fungi. Prevent blood clots that may slow healing. They attack any organism they find unfamiliar and have no way of recognizing pathogens they have already been exposed to. Like macrophages, they eat the pathogens.

2) Thrombocytes (platelets) there are 200k - 400k in blood

-> platelets are cell fragments made from megakaryocytes chopped up. They help with blood clotting

[isthisahearmeout]

Is the white blood cell (U-1146) from Cells! At Work a hear me out?

Yes

No

Voting ended onApr 5, 2025

[Clarification; yes = yea, that's a choice & no = that's rather tame/vanilla pick]

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[Only requirement for submissions is that the character is fictional]

[nomestapgetes]

Quanxi as an NK cell.

[drawittoknowitmedical]

Pathology Glossary: Acute Inflammatory Response

Review the acute inflammatory process and learn how it relates to both healing and pathology

[missnoodliness]

Leukograms - Neutrophils

We talked about blood smears before and they are showing up again! Leukograms are the portion of the CBC pertaining to white blood cells. White blood cells are the surveillance team for the body, killing pesky bacteria, cleaning up after themselves, directing healing, and so much more. They are fantastic little cells!

An analyzer is a great thing to have in a veterinary practice and there are varying kinds, each with their pros and cons. The downside of all of them is that they cannot do your job for you! That means making a blood smear, drying it, staining it, and then sitting your butt down at the microscope to evaluate it. Your blood count just is NOT complete without a blood smear.

We’ll talk about neutrophils, monocytes, lymphocytes, eosinophils.  Basophihls I will not really talk about because they are rarely seen and we know so little about them that it’s not useful for me to speculate on them here.

Let’s look at some White Blood Cells (WBCs)

Cells we expect to see besides Red Blood Cells and Platelets,

Neutrophils

These guys are the first responders and they phagocytize (internalize and kill) bacteria. Fun fact, they are the main component in pus of most of our domestic species. Some animals, like rabbits, do not have neutrophils, but a slightly different cell to serve a similar function!

They look different in different species, but serve the same basic function.

The band neutrophil shown at the bottom is an immature form, whereas the others are called ‘segmented’. The presence of band neutrophils in itself is not a problem. Animals make more of them all the time. When the storage of mature cells has been depleted, we expect to see an increased number of band neutrophils. The body will pump out immature neutrophils instead of having none to put out at all. What’s the issue?

Band neutrophils are not as competent as their mature counterparts are. When band neutrophil numbers get high while segmented neutrophils are low, this is termed a ‘left shift’. If we have an infection, we want increased numbers of both segmented and bands!

What happens when we hurry?

Neutrophils undergo ‘toxic’ changes. These are not due to the presence of toxins, but indicate the hurried way the bone marrow is producing and pumping out the immature neutrophils. This includes a ‘foamy’ appearance of the cytoplasm, cytoplasmic basophilia (looks more purple) meaning that RNA has been retained, and the presence of Dohle bodies which are aggregates of RNA.

Next time we will talk about monocytes!

[studydev]

[twooatomsinamolecule]

12.8.17 // Plasma cell (may be present in multiple myeloma) •• Ringed nucleus in a neutrophil (may be present in multiple sclerosis)