Born on October 25, 1940, Major is a trans women well known as a leader in the broader trans community and an activist, with a particular focus on black and incarcerated trans women. Major grew up in Chicago's South Side and participated in the local drag scene, during her youth. Major described the experiences as glamorous, like going to the Oscars. While she did not have the contemporary language for it, Major has been out as a trans women since the late 1950s. This made her a target of criticism, mistreatment, and violence, even among her queer peers. Majors transition, especially getting her hands on hormones, was largely a black market affair. Given the lack of employment opportunities for black trans women at the time, she largely survived through sex work and other criminalized activities. At some point Major moved to New York City and established herself amongst the cities queer community, despite the prejudice against trans women. She participated in the 1969 Stonewall Uprising. Later, after getting convicted on a burglary charge, Major was imprisoned with men at Clinton Correctional Facility in Dannemora, NY. There she met Frank "Big Black" Smith, a participant in the 1971 Attica Uprising at Attica Correctional Facility. He treated Major, and her identity as a woman, with respect and the two built a friendship. Smith also taught Major a good bit about advocating for herself and other trans women being mistreated by the US Justice System. Major was released from Dannemora in 1974. Major moved to San Diego in 1978 and almost immediately began working on community efforts and participating in grassroots movements. Starting by working at a food bank, she would go on to provide services directly to incarcerated, addicted, and homeless trans women, and would provide additional services after the AIDS epidemic started. In the 1990s Major moved to the San Fransisco Bay Area, where she continued her work, alongside organizations like the Tenderloin AIDS Resource Center. In 2003 Major became the Director of the Transgender Gender Variant Intersex Justice Project, shortly after its founding by attorney and community organizer Alexander L Lee, a trans man. The group works to end human rights abuses in the California Prison System, with a focus on trans, intersex, and gender variant POC. The position has since been passed on to Janetta Johnson, a previously incarcerated trans woman who mentored under Major. She is the focus of the 2015, award winning, documentary Major!. Major has five sons, two biological and three runaways she adopted, after meeting them in a California park. Her oldest son, Christopher was born in 1978, and her youngest, Asiah (rhymes with messiah) in 2021. At 82 years old Miss Major Griffin-Gracy continues to be an active member of her community and an advocate for our rights as trans people.