When you think about it, a lot of the other timelines of the games and their events were kickstarted by one or several witches in some form or fashion.
The Beast's Creators - Kingdom
The Beasts were baked by certain Witches to bring peace and prosperity to the Cookie world.
Unfortunately, each of the five corrupted into evil one by one, their Virtues twisting into darker versions of what they once were.
The Firsts and the Shadow Witch - Witch's Castle
All the First Cookies were human Witches that became Cookies. The Witch of Light and twelve other witches wanted to use the essence of Life to cleanse ignorance and greed.
But the pride of one of the witches ruined their attempt (First Egg Cookie). The Witch of Light gave the witches Cookie bodies to save their souls.
You also have the Shadow Witch, who was the one who baked Gingerbrave in this timeline. She's also seeking the Cookies of the First Batch.
The Burnt Witch - Tower of Adventures
While we haven't seen The Burnt Witch, recent stories have given a bit more insight on her and her actions.
The Burnt Witch is the creator of the Tower's Oven. The Burnt Witch layed a curse on the Tower that turned it into pancakes (hence why it's called the Pancake Tower), almost causing it to fall and be destroyed.
After preventing the collapse, Daccus, the witch's curse, along with things that deceive hearts and charred emotions, were sealed inside the oven.
Then a Cookie with no memory or identity of their own began consuming the negative memories and emotions inside the Oven, turning into Melanchream Cookie. She would then share the memories she consumed with other lifeless dough to form the other three Calamities, and consume Daccus, the origin of her powers, to obtain her monster form, destroy the Oven's seal, letting loose the darkness that was sealed inside of it for so long, endangering the Cookies and the Tower once more.
Which... honestly, your guess is as good as mine on how this is gonna involve a Witch in some way if it does. 😅