At A Decent Hour @atadecenthour-blog - Tumblr Blog

The bride was lovely, but the groom was a little stiff.

Did You Know You Can Legally Marry A Dead Person? It’s Called A Ghost Marriage

Its pretty incredible how accurate the science of astrophysics has gotten. New Horizons actually arrived 72 seconds early after travelling for almost 10 years straight to its destination.

haithinkimfunnny

Hello! The person who calculated the arrival time of New Horizons was Yanping Guo, mission design leader and one of the women who made up 25% of the New Horizons team. She configured the entire mission trajectory, including Jupiter and Pluto flybys.

Women’s contribution to the sciences has a long history of being erased, so let’s not forget the women who made New Horizons possible!

Kneeling from left to right: Amy Shira Teitel, Cindy Conrad, Sarah Hamilton, Allisa Earle, Leslie Young, Melissa Jones, Katie Bechtold, Becca Sepan, Kelsi Singer, Amanda Zangari, Coralie Jackman, Helen Hart. Standing, from left to right: Fran Bagenal, Ann Harch, Jillian Redfern, Tiffany Finley, Heather Elliot, Nicole Martin, Yanping Guo, Cathy Olkin, Valerie Mallder, Rayna Tedford, Silvia Protopapa, Martha Kusterer, Kim Ennico, Ann Verbiscer, Bonnie Buratti, Sarah Bucior, Veronica Bray, Emma Birath, Carly Howett, Alice Bowman. Not pictured: Priya Dharmavaram, Sarah Flanigan, Debi Rose, Sheila Zurvalec, Adriana Ocampo, Jo-Anne Kierzkowski.

(Credit: Michael Soluri for image)

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neurosciencestuff

(Image caption: Mice received injections of drugs that specifically block the activity of two different molecules. Blocking those molecules reduced pain symptoms coming from nearby nerves. Credit: Hiroshima University)

New targets for reducing nerve pain identified

A specific molecule involved in maintaining pain after a nerve injury has been identified and blocked in mice by Hiroshima University researchers. These results reveal a promising therapeutic strategy for treating neuropathic pain.

Mice with an injury to their sciatic nerve showed less pain after multiple injections of a drug that blocks the activity of a molecule called high-mobility group box-1 (HMGB1). Researchers also discovered that a single dose of a drug to block the activity of a different molecule, called matrix metalloprotease-9 (MMP-9), could also alleviate pain from the injury.

The chemical pathways that these drugs use to inhibit HMGB1 or MMP-9 are different from common pain relievers, like opioids (Morphine) or acetaminophen (Tylenol). Therefore, the potential for addiction or negative side-effects may be reduced.

The results reveal that the drug to block HMGB1, called anti-HMGB1, has the downstream effect of preventing the increase of MMP-9 that would normally be expected when HMGB1 increases. Therefore, an inhibitor of MMP-9 may be a more direct route to produce the same effect. This is the first study to link HMGB1 and MMP-9 together in the cellular process of maintaining pain.

A research team led by Professor Yoshihiro Nakata, PhD, at Hiroshima University’s Institute of Biomedical and Health Sciences began their investigation of sciatic nerve pain as part of their long term studies of the central nervous system.

Sciatic nerve pain, or sciatica, causes pain in the lower back, buttocks, or back of the leg and is often caused by a herniated disc in the spine or a pinched nerve. Similar pain can occur in different nerves in patients with cancer or diabetic neuropathy.

Previous studies by other research groups have injected anti-HMGB1 underneath the protective membranes surrounding the nerve. This method, called an intrathecal injection, is more complicated for doctors to perform and has more potential risks.

Prof. Nakata’s team demonstrates a pain-relieving effect from injecting anti-HMGB1 into the hip in the slightly broader area around the nerve, called a perineural injection, avoiding the complications of other injection methods. A localized injection also avoids the potential side-effects of delivering the drug through larger body systems, like a pill into the digestive system or an injection into the blood.

Blocking HMGB1 lessened pain with no negative impact on healing. Selectively blocking MMP-9 also relieved pain with no obvious changes to the activity of other molecules responding to the injury.

The results of this Hiroshima University study show promise for relieving nerve pain with a chemically specific approach that is convenient for patients.

#where do i sign up

captainjackssingalongblog

So the next show I’m doing is Streamers and it’s going to be intense. If you’re up for some intense fucking theatre, come check us out. Trigger warning: violence, language, brief nudity, implied rape, gallons of stage blood.

#quoth the literate #theatre

diedinpompeji-deactivated201505

hanthelion

Pluto 2015 // NASA

rpmememaker

Sentence Meme [ smut & innuendo version ]

• ”You look good enough to eat.” • ”Come here.” • ”Is this okay?” • ”This is going differently than I imagined.” • ”Tell me.” • ”I’m not expecting anything. I just want to…” • ”That is the sexiest thing I’ve ever heard.” • ”Just let me take care of you.” • ”You look incredible like that.” • ”Are you sure this is okay?” • ”Well, I mean, I’m not going to stop you if that’s what you want to do.” • ”I just want to watch you.” • ”Oh really?” • ”Say it again.” • ”What do you want me to say to that?” • ”That was hotter than it had any right to be.” • ”I can’t take my eyes off of you.” • ”Lights on or lights off? • ”Do we need a safeword?” • ”How do you want me?” • ”Is it just how you pictured it?” • ”Wait! Just… wait.” • ”Is that too kinky?” • ”I had no idea you had such good ideas.” • ”Do you want me to stop?” • ”Should I keep going?” • ”Tell me when you’ve had enough.” • ”Don’t you dare stop.” • ”You’re killing me here, you know that right?” • ”Just watch me.” • ”Should we use rope or handcuffs?” • ”Don’t move.” • ”You are such a tease.” • ”I like making you wait.” • ”It’s bigger than I imagined.” • ”Should we try it or not?”

#writing prompts

clonerightsagenda

I understand that a lot of people enjoy writing shipfics where they transplant characters into a college setting. Since some writers may not be in college, or may have graduated a...

#writing prompts

areyou-stillawake

#weird shit #but okay

wolverxne

Photographer Tim Carter captured these adorable images of this Red Fox playing, stretching and sleeping in the snow.

#adorable things #photography

catsbeaversandducks

Russian Photographer Captures The Cutest Squirrel Photo Session Ever

Photos by ©Vadim Trunov - Via Bored Panda

npr

Weekend inspiration. -Emily

#adorable things #photography

gogoodshare

Solar eclipse from space

#pretty things #science #solar eclipse #spacey wacey

sidestuiff

A big mix of them, so have fun with them! Intrigue, revolts, and fairytales~

“Your majesty, the invaders have breached the castle walls — you must flee!”

“I pledge my fealty to you.”

“One day, you will become a fine ruler of this land.”

“I need no king/queen.”

“You should do...

#writing prompts

adorablespiders

jumping spider mama and her babies

image source

#pretty things #science #spiders

memesforu-blog

“Shut your mouth or you’ll never see the light of day again.” “If they’d hurry up with the ransom, I wouldn’t have to keep you as long.” “Stop squirming.” “Scream to your heart’s content, Princess. No one can hear us out here.” “Not sure I’m ready to let you go just yet. It’s too...

#writing prompt

greelin

but what if a vampire drank the blood of someone who was anemic like would they be seriously grossed out

“what the fuck is this”

“i have anemia”

“can you take something for that you should probably take something for that this shit is nasty to drink let alone have running through your body i’m setting up a doctor’s appointment for you”