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mynotes4usmle

Multiple Myeloma

Plasma cells neoplasm => >20% plasma cells in bone marrow

How to recognize plasma cells? nucleus excentrally placed & perinuclear halo (clear cytoplasm arround nucleus)

Most common primary tumor arising in the bone marrow of adults.

Lab & Blood Smear

Monoclonal Ig spike => IgG= 60%, IgA= 20%

High serum protein

Normal albumin

Rouleaux formation

Urine: Bence-Jones Protein (light chains casts)

Clinical Manifestations

Multiple lytics lesions due to OAF (Osteoclastic Activating Factor) => Bone Pain => Fractures

Hypercalcemia => Renal Failure

Complications: Infections, Primary Amyloidosis (AL chains), Myeloma Neprhosis, increased IL-6 (poor prognosis)

lovecrumbss

oh to have foxes play where I've laid to rest

suiheisen

*calling your colleague voluptuous* *begging him for kisses* *bouncing on it (his lap, while manifesting a goal)* yeah. checks out. just a normal day at the office for them

local-gun-witch

Source: merletails

I'm gonna miss the boopening. You may have been here only for a day and half, but you brought the joy of many many MANY boops to completely random strangers, watchers and mutuals. God speed you adorable chaotic kitty paws.