Therapeutic proteins are proteins that are engineered in the laboratory for pharmaceutical use, including non-covalent binders, therapeutic proteins such as enzymes and albumin are having properties such as breaking of covalent bongs and therefore has wide application of treatment .Therapeutic proteins are highly effective in vivo and in-vitro treatment of diseases. Oral vaccines are biologically prepared products, which provide active acquired immunity to diseases such as cholera, polio, rotavirus, smallpox, yellow fever, and others. An oral vaccine comprise an agent resembling to the disease causing microorganism. The vaccines are generally developed from live attenuated or killed forms of the disease causing microorganism, its toxins, or its surface proteins.