Novochizol SA

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Hyperhidrosis: Novochizol™-mediated extension of Botulinum toxin-specific inhibition of sweating in rats The operating hypothesis tested: Novochizol™-formulated Botulinum toxin extends the anti-perspiration activity of a commercial preparation of Botulinum toxin (Xeomin ®) following subcutaneous injection and pilocarpine stimulation in rats. Read here to learn the result: https://www.novochizol.ch/drug-formulation/hyperhidrosis/

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WATCH: CAR T Cells Fantastic Voyages of Serial Killers

First episode of the Oncology Biotech 12-pack , a unique learning solution that combines video lectures with an interactive knowledge base to help all stakeholders in healthcare work together better. Published on iversity.org, the distance learning platform of Springer Nature.

Watch more of our videos here https://www.novochizol.ch/video-collections/

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WATCH: Common colds vs Covid-19

AT1R INHIBITORS TO TREAT COVID19 PATIENTS CALL FOR ACTION

We are a group of doctors and researchers, that believe that AT1R antagonists, such as Losartan or Valsartan, will provide substantial clinical benefit to acutely ill SARS-CoV-2-infected patients.

Watch more of our videos here https://www.novochizol.ch/video-collections/ 

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NOVOCHIZOL RESEARCH AND DEVELOPMENT:

BREAKTHROUGH CHITOSAN FORMULATION OF BOTULINUM TOXIN

Intracellular Delivery in Different Tissues, Enabling New Mechanisms of Action

Chitosan, a derivative of chitin, is the second must abundant polysaccharide on earth. It has numerous applications in healthcare and other fields, but its inherent characteristics limit its use.

Novochizol™ technology quantitatively transforms single linear chitosan molecules into uniformly sized nanoparticles that can be used alone, as excipients, emulsifiers or carriers of countless active ingredients.

Novochizol™ overcomes the limitations of chitosan, enhances its existing beneficial properties and displays new characteristics, offering first-in-class solutions for bioadhesive, sustained tissue-targeted drug delivery.

Learn more: https://www.novochizol.ch/wp-content/uploads/2021/07/teaser_-novochizol_botulinum_toxin.pdf

Visit our website https://www.novochizol.ch/

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Research and Development: 

Effects of Novochizol-Based Fungicide Formulations on the Phytosanitary State Of Seeds, And on the Growth And Development Of Seedlings Of Spring Wheat

Learn More: https://www.novochizol.ch/wp-content/uploads/2021/07/fongicide_formulation_report.pdf

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Brain Surgery: Novochizol™-bacterial cellulose for duraplasty

Bacterial cellulose impregnated with Novochizol™-formulated vancomycin offer several advantages over the current gold standard dural substitutes.

Learn More: https://www.novochizol.ch/medical-devices/duraplasty/

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Resistant Hypertension: In situ inhibition of renin release

Novochizol™ - formulated botulinum toxin injections into renal arteries inhibit renin release, resulting in lower arterial blood pressure over extended periods of time. Novochizol™ enables a new mechanism of action.

Learn More: https://www.novochizol.ch/drug-formulation/hypertension/

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Atrial Fibrillation: A New Weapon Against An Emerging Epidemic

Novochizol™ - formulated botulinum toxin injections into epicardial fat pads lead to long-term suppression of atrial fibrillation and complete abolition of cardiac vagal response.

Learn More: https://www.novochizol.ch/drug-formulation/atrial-fibrillation/

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SYSTEMS THAT LIMITS THE USE OF FERTILIZERS AND PESTICIDES

Organic Farming: Limiting the Use of Fertilizers and Pesticides

Organic farming has many benefits both nutritionally and environmentally. As an agricultural system that limits the use of fertilizers and pesticides to only those of organic origin. The lack of chemicals means the food it produces is relatively free of toxins harmful to human health. It also allows for the preservation of nutrients in soils that are necessary for the life and development of thousands of insects and plant species. As a result, farmland increases its fertile life span across generations unlike industrial agriculture, which quickly where arable land can quickly become poor.

Fungal Infections

One of the organic farming’s major challenges however is fungal infections. When it comes to battling fungi, organic farmers have a limited spectrum of treatments available. The problem with fungal diseases, especially when it comes to organic agriculture, is that once fungal infections take hold of a crop, their reappearance in subsequent seasons is very likely. Even when infected plants are destroyed. This can happen because fungal spores are capable of overwintering in soil and sometimes overlooked infected foliage also contaminates the soil. This will cause the soil to effectively become a reservoir of fungal infections for years.

One solution, the Bordeaux mixture – a solution of copper sulfate, lime, and water – has been used since the 19th century to control fungal infections of vegetables, fruit, nuts, trees, and ornamental plants. While various copper solutions and powders have been used for centuries to control diseases in plants and trees.

Today, the Bordeaux mixture is used particularly in grapes, potatoes and sugar beet crops. Historically, these copper mixtures were sprayed repeatedly, up to several times per season, and in huge amounts (e.g. 500g per hectare per application). More recent products have allowed farmers to use 150g per hectare per application but this still represents a large amount of copper.

Solution to disease control in plant and soil contamination

But what if we could reduce the number of applications and copper needed to just 1 or 2g per hectare? Wouldn’t that be amazing?

An organic-friendly solution that is itself naturally occurring, is chitosan; a derivative of chitin the second most abundant polysaccharide. Both as a stand-alone product or in combination with other polymers, limiting the use of fertilizers and pesticides. Chitosan has been extensively used in agriculture since it possesses both antifungal and antimicrobial properties. However, its inherent characteristics such as its limited solubility, high viscosity, and degree of variability restrict its use.

Novochizol™, a new molecule inspired by chitosan but with none of its limitations is a promising new advent to organic agriculture. The Novochizol™ transforms linear chitosan into pure chitosan cross-linked globular particles, which overcomes the limitations of chitosan. It also enhances its existing beneficial properties while displaying new properties. Novochizol™ nanospheres can be loaded with copper sulfate loads. These nanospheres are sticky and deliver its cargo through a sustained release mechanism (meaning that their copper loads aren’t released all at one). The Novochizol™ itself may also elicit a plant defense mechanism that in turn also helps the plant by bolstering its ability to ward of fungal infections. In addition, the nanospheres are sharp and can also act as a mechanical deterrent to snails and other organisms.

Summary

Novochizol helps organic farmers keep their crops healthier.

The use of Novochizol nanospheres laden with now far less copper allows for better and healthier, fungus-free crop growing. Moreover, it will limit the harmful effects copper may have on the soil and on human health.

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Copper: The Future of a Very Old Pesticide   KEY POINTS:  • Copper-based pesticides are among the most widely used inorganic plant protection products • Agriculture-related copper accumulation in soil is unsustainable • Dose reduction is the only way forward in copper pesticide practices • Copper compounds can be formulated with Novochizol technology in minutes • Novochizol-based copper formulations offer the promise of dramatic copper reduction • Novochizol is a technology for a precise and sustainable agriculture.  Visit our website at https://www.novochizol.ch

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Novochizol: An Introduction

Novochizol is made from chitosan, a linear polymer derived from a naturally occurring substance called chitin (the second most abundant polysaccharide on earth). Chitosan was invented 150 years ago and is now used in a range of industries from wastewater management to highly complex sectors, like drug formulation.

Today, however, Novochizol retains all the beneficial characteristics of chitosan but opens a world of new possibilities thanks to its unique transformative design. Single molecules of chitosan of a defined size are activated and then made to undergo an intramolecular reaction wrapping themselves into uniform nanospheres.

These properties allow Novochizol to overcome all the major limitations of chitosan. For example, while chitosan is soluble at acidic pH’s only, Novochizol suspensions are pH independent. Novochizol’s low viscosity as compared to chitosan allows it to be delivered as injectables, aerosols and through other mediums that chitosan was never considered for due to its high viscosity. In addition, Novochizol, decomposes slowly and is very stable, yet retains the fully biodegradable properties of chitosan. And finally, because Novochizol is a spherical shape, it can be purified and calibrated much more easily than the linear and heavy polymers of chitosan.

But the real power of Novochizol lies in its ability to formulate all classes of active ingredients: small molecules, peptides, nucleic acids, proteins, even viruses and cells. And it also acts as powerful emulsifier, bringing into solution even the most hydrophobic active ingredients. Many different formulations are possible: hydrogels, low viscosity suspensions, aerosols, even 3D printing ink to create soft or hard objects of all shapes.

The possibilities are limitless.

Interested in learning more about Novochizol? Contacts us today to learn more.

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The Big Bang, Simplified for Biology. To watch more of our videos, visit https://www.novochizol.ch/video-collections/

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Medical Devices and Tissue Engineering: Why Choose Novochizol™?

- Customizable hardness: from hydrogels to rigid matrices - Full biocompatibility - Inherent anti-inflammatory properties - Strong adherence to living tissues and other materials - Synergy with a variety of other biocompatible materials - Sustained release of embedded active ingredients

For more information, visit https://www.novochizol.ch/medical-devices/

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Nebulized particles that can get any active ingredient anywhere and everywhere

Aerosols: Why Novochizol?

- Formulation of all classes of molecules as fine aerosols - Generation of aerosol particles of defined size - Strong adherence to animal and plant tissues - Resistance to wash-off and leaching - Proof of concept with 9 drugs for intra-pulmonary delivery

For more information, visit https://www.novochizol.ch/aerosols

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WATCH: CAR T Cells Fantastic Voyages of Serial Killers

The first episode of the Oncology Biotech 12-pack, a unique learning solution that combines video lectures with an interactive knowledge base to help all stakeholders in healthcare work together better. Published on iversity.org, the distance learning platform of Springer Nature.

For more information, visit our website at https://www.novochizol.ch/

[novochizol]

Open Innovation To Develop A Vaccine That Will Help Kill Sars-Cov-2

The Cleopatra VII Project

The current Covid-19 vaccines aim at preventing illness and death. This is wonderful. But they are not designed to eliminate the virus itself, nor prevent its transmission.

In themselves, they will not put an end to the pandemic.

The reason is simple: injectable vaccines elicit systemic humoral and cell-mediated immune responses, but they do little if anything to induce protective immunity on the mucosal surfaces where the virus establishes itself and can reproduce for months, without symptoms, generating potentially dangerous mutant variants each time it reproduces.

Only mucosal vaccines can unleash weapons that directly kill pathogens outside the body before they get the chance to infect any cell. These weapons are secretory IgA antibodies, the first line of defense against all respiratory viruses. But mucosal immune responses are not limited to IgAs, they also engage the complement system, cell-mediated defenses and can jump-start the production of systemic IgG antibodies just in case the pathogen managed to breach the mucosal barrier. And best of all, mucosal immunity can last a lifetime.

Ever wondered why the oral polio vaccine works so well? Now you know.

So why are there no mucosal vaccines against respiratory pathogens?

There are three specific challenges in developing mucosal vaccines:

They must adhere to epithelia, to avoid vaccine loss in mucus secretions.

They must protect vaccine antigens from degradative enzymes in mucus secretions.

They must be sufficiently immunogenic to activate a more tolerant mucosal immunity.

But these challenges must be overcome… and in the midst of the COVID-19 pandemic, there is no time to waste!

Meet Novochizol™: the promise of an ideal mucosal vaccine delivery system.

Novochizol™ technology quantitatively transforms single chitosan molecules into uniformly sized nanoparticles. As a mucosal vaccine delivery system, Novochizol™ offers:

Versatility: RNAs, peptides, proteins and viruses can all be formulated in any form.

Low nasal clearance: Novochizol adheres to epithelia, promising no vaccine loss.

Intracellular transport: Novochizol bring active ingredients inside cells for processing.

Protection: Novochizol protects active ingredients from proteases and nucleases.

Stability: Novochizol formulations are chemically and physically more stable.

Adjuvant properties: Novochizol particles promise to enhance vaccine immunogenicity.

Prior art: Chitosan, Novochizol parent molecule, is an effective Influenza vaccine carrier.

Safety: Preclinical and clinical studies all support Novochizol lack of toxicity and safety.

The CLEOPATRA VII open collaboration project: Join us!

With Novochizol™ technology proven and available, we can address the main challenge in developing the ultimate COVID-19 vaccine: finding the right combination of antigens necessary and sufficient to elicit strong mucosal immunity, leading to full immunization.

We have started to formulate some SARS-CoV-2 antigens, but we need more variety and know-how in vaccinology. We are thus looking for research organizations that would be interested in helping generate this variety and co-formulate together a killer vaccine, in the very best sense of the term!

How does it work?

Being Novochizol experts we know how to formulate a variety of active ingredients as aerosols for intra-nasal or any other form of mucosal vaccine delivery. And we are doing just that.

We also have access to research facilities to test formulations in animal models for their capacities to elicit the production of relevant classes of antibodies (IgGs, IgAs, IgEs) and other markers indicative of systemic and mucosal immunities. And we will be doing just that.

The rest will be history that we want to write with you.

So, if your organization or company has the capacity, the will, and the wisdom to share samples of SARS-CoV-2 antigens it may have access to and its know-how in vaccinology, Cleopatra VII wants you!

CLEOPATRA VII is an open-source research project.

Just like open-source IT projects that generate the best software, we believe we can do the same by bringing together smart research organizations, companies, and individuals to generate a proof of concept that will lead to a decisive victory in the war against the virus.

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NOVOBEAD: Pushing the boundaries of PCR diagnostics.

Novobead: Novochizol-coated magnetic beads for superior nucleic acid isolation

- Highly selective nucleic acid extraction. - Rapid and high-capacity binding. - Compatible with a wide variety of magnetic beads. - Gain of 2 to 3 cycles in real time PCR and RT-PCR. - Special beads to completely remove nucleic acids from any sample.

For more information, visit https://www.novochizol.ch/in-vitro-applications/