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tamamita

#OK THIS IS IMPORTANT LIKE.#BELDAM YOU SHIT BACK OFF LET HER BE TRANS!!!#TRANS VIVIAN WOOOOO

ourlordapollo

The zoo in my hometown posted this picture of one of their cheetah cubs and I'm obsessed

HIS NAME IS YAM ARE YOU FUCKING KIDDINF ME

carfuckerlynch

[ID: 1. a picture of a juvenile cheeta sitting with a nearly polite posture. he is looking at the camera and the angle makes his eyes enormous. he has blood on his muzzle. /end

2. an illustration of a TBH creature with characteristic big dark eyes sitting in a puddle of blood. it has blood on its mouth and feet. /end ID]

#BAHAHAHAHA THE #THE FUCKING #THING!! THE CREATURE.

frightfullytreeish

reblog to slowblink at your mutuals

spooniestrong

Pritzker Molecular Engineering researchers led by Prof. Jeffrey Hubbell showed that their compound can eliminate the autoimmune reaction ass

rosslynpaladin

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

otteroflore

The stage that they're at is animal testing but it sounds like it's been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is "flagging" the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can't destroy anything, which leaves a person vulnerable to infection.

The newer method is basically "tricking" the body using a method that... the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body "hey, you flagged this wrong" and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn't foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

moreclaypigeons

Thank you for this explanation/synthesis of the article! It's important for us to understand that they're still in early development and testing of these methods, but also that they've seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

astridflies

Hi! I'm a microbiologist and I've done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it's not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there's good data it is safe) and are recruiting for a Phase 1/2 trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It's way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

#finally reblogging again #this is so COOOOL #SCIENCE

Hi! I opened a bigcartel store and would love for people to visit and see what I have for sale! It's currently all corcheted plushes, but may include resin jewelry in the future! Please visit and buy what you like! <3

#bigcartel #store #crochet #plushies #plush artist #amigurumi #monster hunter #sea creatures #dinosaur

the-raven-hearted

Stupid things my players have done

Yes, hello, I am a DM and in conjunction with my group we listed some of the highlights of the silly, ridiculous things they’ve done in our campaign over the last year or so.

My players are @diabeticpasta, as Eloise the Aasimar cleric of Pelor, @rosalicorvus as Suna the dragonborn fighter/ dragon-rider, @shaysscribbles as Xida the gnome rogue/druid, and @stereonobe-no-futo as Lerissa the tiefling bard/artificer.

The one I love most will always be excessive vandalism of the Roll20 maps. They abuse that draw tool. Just look at this beautiful cloud giant @diabeticpasta drew. More shenanigans below the cut!

Keep reading

the-raven-hearted

Today begins my senior year of college, wooooo!

rosalicorvus

WHAT THE FUCK TIME SLOW DOWN HOLY SHIT!!!

0xo

Visit Original Link

a perfect little mp3 for a phone notification tone - so you can let everyone know how much you fucking love bees [x]

shaysscribbles-deactivated20181

FIRST COMMISIONS :D

Hi, I’m Shay, and I’m pretty new things like making art for other people. But I REALLY want to! SO, for anyone that followed me out of appreciation of the much less than frequent drawings I post–and even if you didn’t– I’d like to do something for you guys cause you’re all great! I’m going to take requests if anyone wants to make one! :D

I’m getting some 15x20 art boards that I’ll be using. (I could also make some digitally if you’re not comfortable with me mailing you stuff. xD)

Here is a draft of a drawing i did for a friend as an example:

I can draw a picture of you with an OC of yours, your favorite video game/movie/show character/creature, you and a friend, or anything else you can think of! And NO NSFW please! :)

Even if YOU don’t want me to make you something, I would appreciate a signal boost! Who knows, maybe one of YOUR followers will! And hey, it’s a good way to start getting myself out there, right?

THANK YOU TO ANYONE THAT DIDN’T SCROLL PAST THIS AND TOOK THE TIME TO READ IT

<3 Shayvonna

#!!!#GUYS LOOK AT MY COOL FRIEND'S COOL ART #JUST DO IT

peridootles

thecoolestinfatuation

I know, it’s Breast Cancer Awareness Month..but there are other diseases that need awareness to be raised for as well. I personally don’t have Trigeminal Neuralgia but I know people that do. Stay woke.

mizmoevents-blog

International Trigeminal Neuralgia Awareness Day

https://www.facebook.com/events/1480731248897752/

Today, October 7th, is Trigeminal Neuralgia awareness day. I feel like I really owe it to my mom who has this disease to make a post about it on tumblr to help raise awareness about it. She has been suffering though so much, and the only reason she has to continue living on and waiting for a cure is her family who has been supporting her since day 1. Trigeminal Neuralgia is a disease that affects the nerves in one's face, known as the trigeminal nerve. There's one for each side of the face, and each nerve has 3 branches: in the forehead, the cheek, and the jaw. When these nerves are pressed against by a blood vessel or other obstruction, it causes COMPLETELY UNBEARABLE pain that cannot be stopped. My mother takes tons of medication that was perscribed to help her, but it doesn't do much to help her other than slightly decrease the likelihood of a bad flare-up.There can be surgery done to free the nerve from what's aggrivating it, and my mother has had that procedure done, but there's a chance that it won't work or the pain will come back. And that's exactly what happened to her. Other than that procedure, there are no other known methods of curing this disease. This disease is also extremely debilitating, for the littlest things can trigger flare-ups of pain. Sneezes, loud noises, bending over, getting up too fast, remaining active/walking for too long, doing dishes, cleaning the house, and doing laundry are all things that have triggered a flare-up for my mom. Sometimes flare-ups happen for seemingly no reason. She constantly feels a "burning" pain that never goes away, and flare-ups are described to feel like lightning strikes. I'm on mobile and can't exactly post any sources right now, but if you simply google the term "Trigeminal Neuralgia", plenty of information pops up. I would also appreciate it if other people could reblog this post with sources if possible. It would be wonderful if you could reblog this post and more people can find out about this disease, because awareness is the first step to finding a cure.