#bladder cancer

[viripiendotcom]

hii! the mother of one of my pals has been battling bladder cancer for a while. she's been struggling to afford transportation and her treatments.

if you can comfortably donate, please do so!

https://gofund.me/c53314c3f

[dogs-in-a-trenchcoat]

Help needed:

I don't really know how to write serious posts without feeling like I'm coming off hokey but this is important so I'm just gonna have to deal with that discomfort.

My dad was diagnosed with stage 2 invasive bladder cancer. As of right now we don't have a total quote for his medical treatment, but we've already been struggling to afford the gas to get him to his appointments - let alone that it looks like some of his chemo medications won't be covered by Medicare.

We are hoping to get some help with the costs associated with this diagnosis, so my mom's organized a gofundme. Please help me get some eyes on this, and if you can spare any money I would be eternally grateful.

Support Jims Stage 2 Invasive Bladder Cancer Fight, organized by Vicki Geisler

Dear friends and caring souls, (Summary - We are trying to raise $2… Vicki Geisler needs your support for Support Jims Stage 2 Invasive Bl

[disabilityhealth]

update!

cw: cancer (but it’s good news)

So the last couple of months have been pretty hectic for me, health-wise. As you may know, I had a hysterectomy in July and the surgeon noticed a strange growth in my bladder. I had surgery again in early August to remove it and the pathology came back to confirm that it was cancerous.

Here’s the good news: I just underwent my final round of testing and as of right now, I am cancer free! We caught it extremely early (stage 0), which means I won’t even need chemotherapy unless it comes back. I’ll get tested again in November and then probably yearly for the rest of my life, but I can live with that!

My head is still spinning from getting the worst news of my life followed so quickly by the best news of my life, but mostly I’m just feeling very lucky. 

Now that the stress is off, I hope to be more active on the blog. See you folks in the notes! <3

[zaraillustrates]

I was commissioned by Cedars-Sinai to illustrate an article about breakthroughs in bladder cancer treatment. Innovations in surgical and laboratory work are reducing the risk of recurrence. Patients with early-stage disease now have the option of a procedure called en bloc resection, that allows surgeons to remove the tumor in one piece. Meanwhile, for the 25% of patients whose malignancies invade the bladder-wall muscles - increasing the danger of metastasis - Cedars-Sinai investigators have developed a means of predicting how bladder cancers respond to certain therapies. A big thanks to AD Robert Parsons for this project. © Zara Picken 2022 www.zarapicken.com

[biomedicool]

Bladder Cancer

Causes

Smoking 

A result of chemical accumulation and formation within the bladder epithelium

Occupational Exposure 

Dyes, textiles, rubbers, paints, plastics, leather tanning etc. 

Analine dyes, 2-Naphthylamine, 4-aminobiphenyl, xenylamine, benzidine, o-toluidine

Schistosomiasis infection 

Co-factors: smoking, diet, bacterial infection

Ketamine use 

Ketamine-associated ulcerative cystitis 

Direct toxic damage by ketamine or metabolites 

Microvascular damage 

Trigger of autoimmunity 

Unrecognised bacteriuria 

Types of Bladder Cancer 

Transitional cell 

90% of bladder cancers 

Can be invasive (in situ) or invasive (grown in to muscle layer) 

Arises from transitional cells 

Has further subtypes 

Squamous cell 

5% of bladder cancers 

Associated with shistosomiasis infection 

Adenocarcinoma of the bladder 

1-2% of bladder cancers 

Arises from goblet cells within the bladder 

Other very rare types include soft tissue sarcomas and neuroendocrine tumours.

[iheartguts]

When life gives you interstitial cystitis, make lemonade. 🍋

[intelligentliving]

Breast Milk Compound Found To Dissolve Tumors In Human Trials

Trial results show that cancer patients were able to pass dissolved tumors through their urine after breast milk chemical broke it into fragments.

[bpod-bpod]

Hedgehog vs. Cancer

Named after the eponymous video game and comic book series, the Sonic Hedgehog gene (SHH) plays a role in adult stem cell division. In the bladder, SHH helps block cancer cells from growing, which prompts aggressive cancer cells to turn off the gene. A study looked at how they manage to do this and what happens when SHH is switched back on. Looking at cell DNA from bladder cancer patients, the team found that the SHH gene didn’t have any obvious flaws but found signs of DNA methylation, a process that can switch genes off. When human cancer cells were transplanted into mice, tumours developed (left two columns). However, mice treated with a drug that blocks methylation had less tumour growth and their cancers were less aggressive (right columns). In future, applying these insights about SHH and methylation to the clinic could help develop new treatments to manage more aggressive cancers.

Written by Gaëlle Coullon

Image from work by SungEun Kim and colleagues

Department of Life Sciences, Pohang University of Science and Technology, Pohang, Republic of Korea

Image originally published under a Creative Commons Licence (BY 4.0)

Published in eLife, April 2019

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