#brittle bones

[skkortysoup]

[mailrebel]

Brittle Bones

OOT Zelink where adult timeline Zelda writes letters to Link which she knows he'll never receive. Written for @serenade-of-time

It's pretty sad y'all 🥲

An Archive of Our Own, a project of the Organization for Transformative Works

[inkboundmelody]

fragile <3

⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚

My fragility is a weakness,

a curse thrust upon me when I entered this world. 

Easily broken.

Put back together

with flimsy bandages and endless regret. 

Deeply feeling

and hiding the cracks that splinter,

pain echoes in my bones

and in my glass heart. 

⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚⋆. ˚✩⋆｡˚

and that's on having rare medical issues like brittle bone disease

[bpod-bpod]

Fishbones and Fractures

One bad fall and crack go your bones. But if you have an inherited Fragile Bone Disorder (FBD), even the smallest knock can cause a fracture. Checking whether certain genetic flaws are responsible for FBDs and the impact they have isn’t straightforward in humans due to our genetic diversity and ethical considerations. Researchers have, therefore, made it easier using zebrafish and a technique called crispant screening. They focused on genes previously identified in humans as associated with an FBD. Using a gene-editing technology called CRISPR/Cas9, they created zebrafish lacking these genes. Next, they used microscopy to analyse the skeletons of these mutant fish at different ages after staining their bones (pictured) or fluorescently tagging their bone cells. All mutant fish (middle, bottom) had deformed bones when compared with normal fish (top), with many showing fractures and fused bones. This shows the power of crispant screening in zebrafish to clarify which genes are responsible for FBDs.

Written by Lux Fatimathas

Image from work by Sophie Debaenst and colleagues

Center for Medical Genetics Ghent, Department of Biomolecular Medicine, Ghent University, Ghent, Belgium

Image contributed by the authors under a Creative Commons Attribution 4.0 International (CC BY 4.0) licence

Published in eLife (reviewed preprint), January 2025

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[madelinesmedicine]

-ˋˏ ༻❁༺ ˎˊ- Osteogenesis Imperfecta (OI) aka Brittle Bone Disease -ˋˏ ༻❁༺ ˎˊ-

✎ What is Osteogenesis Imperfecta?

Osteogensis Imperfecta aka Brittle Bone Disease is a group of inherited disorders characterized by fragile bones that break easily.

✎ What cause OI?

Osteogenesis imperfecta is caused by defective genes. These genes affect how the body makes collagen, a protein that helps strengthen bones.

✎ What are the different types?

The different types of OI include:

Type I: This is the mildest and most common form of OI. Type I leads to broken bones (bone fractures) or muscle weakness. It doesn’t cause any bone deformity

Type II: Babies born with Type II often can’t breathe and die young. Type II causes multiple broken bones even before the baby is born

Type III: Babies often have broken bones at birth. Type III often leads to severe physical disabilities

Type IV: Bones may break easily. Usually, children with this type have their first bone break before puberty. People with Type IV may have mild to moderate bone deformity

✎ What are the symptoms of OI?

Bone deformity and pain

Bruising easily

Difficulty breathing

Hearing loss

Loose joints or muscle weakness

Curved spine

Small stature

Triangular face shape

Weak, brittle or discolored teeth

Blue sclerae (bluish color of the whites of the eyes)

It is important to note that not everyone with OI has every one of these symptoms.

✎ How is OI treated?

Treatment may include, occupational therapy, physical therapy, assistive devices, oral/dental care, and medications

✎ How are broken bones as a result of OI treated?

A broken bone will either be treated with a splint, brace, cast, or surgery. A rod may be placed in surgery to support the bone and to prevent it from breaking again in the future.

✎ Is there a cure for OI?

Nope. Treatment can help but this condition doesn't have a cure.

✎ How is OI diagnosed?

A blood test and bone density tests are use to diagnose OI. However, a baby may break a bone before birth which is often a major sign that the baby has OI and a doctor may or may not conduct tests.

✎ Extra information/fun fact

I myself am diagnosed with OI and have had quite a few broken bones.

[disabilityhorizons]

StrongBones Charity are doing a (UK only,sorry) giveaway of equipment for children and young adults with a bone condition. Please shre if you know anyone who would benefit. Can be used for gaming, switches, controllers, tablets, toys and crafts. https://tinyurl.com/wbalhtm

[ad-on-the-am53]

They're both non-binary, the Skeleton has a gun

[oicandresstoimpress]

So many times we go to the mall, buy new pieces & hang them in our closets without giving the other items a second thought. We pile new items in not realizing that you may have pieces that would go perfect with the old ones. We all need to take time & do a closet overhaul. Simply put, clean out your closet!! A few days ago I was looking through my armoire & for the first time in forever I noticed a blazer that I completely forgot I had. Right then, I began riffling through & I swear I should be ashamed of myself..... I had pieces with the tags still on, stuff I bought 3,5 years ago. Honestly, I don’t even need to buy shit else!!!!!! So I’m always looking to do new projects & I decided that once a week, I will go through my closet & armoire & put some pieces together. I will post it both here & my Instagram (@YooooooItsPeach) & then later post a photo of me wearing what I’ve put together. This project is totally multiplexed because not only am I sifting through my clothes, It’s also giving me the opportunity to see what toss (donate) & what to keep. It also gives me ideas of how to wear various pieces outside of my norm. It’ll give other petite women like myself some ideas of how to pair. ✨😌✨