#interview with the vampire#iwtv#the vampire armand#assad zaman
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The ene-Myc is an ally-GATOR: lymphoma defeat must happen through metabolism
According to the Global Cancer Observatory, there were over 630,000 new cases of lymphoma worldwide in 2022, highlighting the urgent need for better understanding of the molecular mechanisms that drive this disease. Scientists already know that at least 70-80% of lymphoma cases rely on the activity of the proto-oncogene c-Myc and aberrations in regulators of the cell death pathway are well known…
FOXes R 2 clever to go undetected: but when it comes to children, "targeted" shots are needed
Pediatric tumors are a field of oncology that has always had special attention that needs no explanation. Tumors such as neuroblastoma and medulloblastoma are among the most frequent tumors of the nervous system in children and basic research is making great strides in understanding the molecular defects affecting these types of cancer. For example, it has been understood that among the thousands…
NeMyco giurato: ricerca e medicina di precisione contro il medulloblastoma
I tumori cerebrali sono la causa principale di decessi per cancro infantile e il medulloblastoma è il tipo più comune di tumore cerebrale nei bambini. Colpisce circa 500 bambini ogni anno in Canada e negli Stati Uniti, rendendo la diagnosi e il trattamento migliorati una priorità assoluta nell’oncologia pediatrica. Mentre alcuni bambini con medulloblastoma rispondono bene al trattamento, altri…
Fattori di trascrizione: i "direttori d'orchestra" cellulari della salute umana
Fattori di trascrizione e salute umana I fattori di trascrizione sono proteine essenziali che regolano l’espressione genica, influenzando la trascrizione del DNA in RNA messaggero (mRNA), che è il primo passo della produzione di proteine. Essi si legano a sequenze specifiche di DNA, chiamate promotori o enhancer, per attivare o reprimere la trascrizione dei geni. Sono cruciali per il controllo di…
Though "poker faces", psoriasis and skin diseases show their last CARD: 1 4 Myc should be enough
Our skin, the body’s largest organ–provides the first line of defense against infections and many other threats to our health. Decades of research has shown that a wide range of diseases can occur, or become worse, when the skin cannot form an effective barrier. Millions of people are affected by eczema, psoriasis and other inflammatory skin disorders. Now, experts in human genetics and asthma…
Researchers see an unprecedented degree of nerve regeneration using proteomics.
Researchers see an unprecedented degree of nerve regeneration using proteomics. Thoughts health innovators?
Using proteomics techniques to study injured optic nerves, researchers at Boston Children’s Hospital have identified previously unrecognized proteins and pathways involved in nerve regeneration. The new study showed that adding back one of these proteins, the oncogene c-myc, achieved unprecedented optic nerve regeneration in mice when combined with two other known strategies. The opensource study…
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The retinoblastoma protein inhibits cancer by controlling cell division. Now, researchers have shown that it also binds to and inhibits genes necessary for pluripotency — a defining characteristic of stem cells.
Repopulation of Damaged Livers With Skin-Derived Stem Cells
Repopulation of Damaged Livers With Skin-Derived Stem Cells
Patients with severe liver disease must receive a liver transplant. This major procedure requires that the patient survives major surgery and then takes anti-rejection drugs for the rest of their lives. In general, liver transplant patients tend to fair pretty well. The one-year survival rate of liver transplant patients approaches 90% (see O’Mahony and Goss, Texas Heart Institute Journal2012…
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