#holoprosencephaly

[hongrelmog]

Examples of babies with otocephaly and holoprosencephaly, two related disorders of embryonic development. Otocephaly results in the lack of a mandible, reduced or absent mouth and tongue, and fusion of the ears. Holoprosencephaly results in the failure of the brain to divide into two hemispheres, which in turn causes the features of the face such as the eyes and nostrils to partially or completely fail to divide.

[duckyfann9871]

Just remembered that there is a Sonic-Hedgehog gene and how if you discover a gene you get to name it whatever you want, time for me to dedicate my PhD to the up and coming Shadow-hedgehog gene

[sewiders]

Happy disability pride month to people with brain malformations btw.

[justkidneying]

An Example of Scientists Being Nerds

What do Sonic the Hedgehog and cyclopia have to do with each other? A lot, actually.

Alobar holoprosencephaly (aka cyclopia) is a condition in which the prosencephalon does not properly split during development. Let me explain what that means. So, one of the most important structures in the early embryo is the neural tube. This tube comes from the ectoderm and eventually becomes the central nervous system. The top of it has three little bulbs and the bottom is the spinal cord.

The top bulb is the prosencephalon, which will later differentiate into the telencephalon and diencephalon. These will become the cerebral hemispheres, basal ganglia, thalamus, hypothalamus, and amygdala. The middle bulb is the mesencephalon, which will become the midbrain. The bottom bulb is the rhombencephalon, which will differentiate into the metencephalon and myelencephalon. These will become the pons, cerebellum, and medulla.

So, this entire thing has to split in half anteriorly. The anterior portion of this structure deals with motor function, and the posterior half deals with sensory function. This holds true as an adult. The front half of your spinal cord carries motor nerves, and the back half carries sensory info. If you want to move your eyes, you use the front part of your brain. If you want to know what you are seeing, you use the back half.

If you look at your spinal cord, the front half has this fissure down the middle (anterior median fissure is such a fitting name, then right??). Your brain is also split down the middle. Since the eyes are part of your brain, you get one for each half of the brain (two). Now, let's say you never have this anterior fissure form... you won't get two eyes, either. The condition where the fissure doesn't form is called holoprosencephaly (holo means whole).

There are five types of this (in order of decreasing severity): alobar, semilobar, lobar, syntelencephaly, and microform.

*note that the more severe the condition is, the more likely the fetus will die and not form all structures mentioned*

Alobar: there will be one eye, a proboscis (fleshy tube on the face), and severe mental impairment.

Semilobar: eyes will be close together, the nasal bridge will be flat, the palate and lip will be cleft, and there will be mental and ocular impairment.

Lobar: the eyes will be close together, the nasal bridge will be flat, the nostrils will be close together, and there will be some mental impairments.

Syntelencephaly: flat nasal bridge, shallow philtrum, and possible mental delays.

Microform: eyes may be close, nasal bridge will be sharp, and there will be one central upper incisor.

Okay, so what does this have to do with Sonic the Hedgehog? Sonic hedgehog (SHH) genes, of course! This gene codes for the sonic hedgehog protein, which controls what happens during organogenesis (how everything differentiates and forms). A mutation in this gene can cause issues with how embryos form, and is indicated specifically in holoprosencephaly. SHH genes are still important in adults, and mutations can be linked to certain cancers.

Fun fact: an inhibitor of SHH genes is called Robotnikinin. I personally love this. And, here's a citation in case you don't believe me: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2770933/

[mamas4healthcare-blog]

This is my dtr Hannalise Rose. I found out at 27 weeks she has a congenital brain malformation known as Holoprosencephaly (HPE or HoPE). She has the moderate form known as semi-lobar. HPE effects the frontal lobe of the brain and its division into left and right hemispheres. 3% of children survive delivery and of that 3% only 1% survive 6 months of age. Hanna just turned 4 in February! HPE can cause lots of complications and effects each child differently. Hanna’s HPE has caused her to have Microcephaly, Spastic Quad Cerebral Palsy, Diabetes Insipidus (issues with sodium levels NOT blood sugar), Aspiration Risk, Developmental Delays, ACC (Agenesis of Corpus Callosum- the structure in between the hemispheres that helps messages cross back and forth), amongst other issues. She is considered nonverbal (she can say a handful of words consistently and others inconsistently but she is unable to verbalized her needs/wants essentially). She is very social and personable. She is very observant and does comprehend.. she just has about a 15 second delay in processing. She is unable to sit, stand, or walk on her own. Because of her CP she has lots of issues with high tone/spasticity. She is hospitalized at least once a year for an ear or respiratory infection. Thus far this year she has been twice. She is my light!☀️🌼

[jansancharbharat]

बक्सर के सिमरी में दुर्लभ साइक्लोपिया विकार से पीड़ित नवजात का जन्म, उच्च चिकित्सा केंद्र रेफर

बक्सर (सिमरी), 6 दिसंबर 2025: सिमरी प्रखंड के सामुदायिक स्वास्थ्य केंद्र में शुक्रवार को एक ऐसा जन्म हुआ जिसने पूरे अस्पताल को हिला कर रख दिया। राजपुर पंचायत के त्वकलराय डेरा निवासी रवि यादव की पत्नी रिंकू देवी ने जिस बच्चे को जन्म दिया, उसमें जन्म के साथ ही गंभीर शारीरिक असामान्यता दिखी। नवजात की आंखें एक ही जगह मिली हुई थीं और नाक का उभार माथे के ऊपरी हिस्से में था। प्रसव कक्ष से लेकर पूरे…

बक्सर के सिमरी में दुर्लभ साइक्लोपिया विकार से पीड़ित नवजात का जन्म, उच्च चिकित्सा केंद्र रेफर

[radsiarai]

Holoprosencephaly_Sound therapy session_Sounds of nature

Holoprosencephaly is a rare and complex neurological disorder characterized by abnormal brain development. Traditional medical treatments for Holoprosencephaly focus on managing symptoms and supporting overall development. However, recent research suggests that incorporating resonant frequency sound therapy as an adjunctive treatment can provide additional benefits. Resonant frequency sound therapy is a non-invasive therapeutic approach that utilizes specific low-frequency vibrations to stimulate the body's natural healing processes. It is based on the principle that every organ and tissue in our body emits its own unique resonant frequency. By introducing carefully calibrated sound waves, resonant frequency sound therapy aims to restore balance and promote optimal functioning. Resonant frequency sound therapy has the potential to stimulate neurological pathways and enhance brain function. By introducing therapeutic vibrations, this therapy may help activate dormant areas of the brain affected by Holoprosencephaly. Neurological stimulation can facilitate neural connections, potentially improving cognitive function, motor skills, and overall neurological development. Holoprosencephaly can be emotionally and physically challenging for both individuals and their families. Resonant frequency sound therapy has shown remarkable potential in inducing deep relaxation, reducing stress, and promoting a sense of calmness. By alleviating emotional and physical stress, this therapy may support overall well-being and improve the quality of life for individuals with Holoprosencephaly. Many individuals with Holoprosencephaly experience sensory processing difficulties. Resonant frequency sound therapy can aid in sensory integration by providing gentle and consistent sensory input. These therapeutic vibrations can help individuals regulate their sensory experiences, potentially improving their ability to process and respond to sensory stimuli. Resonant frequency sound therapy offers a holistic approach to the treatment of Holoprosencephaly. By addressing not only the physical symptoms but also the emotional and energetic aspects of the individual, this therapy complements traditional medicine and supports a comprehensive treatment plan. The combined approach can provide a more well-rounded and multidimensional approach to managing Holoprosencephaly. Resonant frequency sound therapy has the potential to improve overall well-being for individuals with Holoprosencephaly. The therapeutic vibrations can promote relaxation, reduce pain and discomfort, and enhance emotional and mental well-being. By fostering a state of balance and harmony within the body, this therapy may contribute to a higher quality of life for both individuals and their families. Resonant frequency sound therapy shows promise as an adjunctive treatment for individuals with Holoprosencephaly. By providing neurological stimulation, promoting relaxation, supporting sensory integration, and offering a holistic approach, this therapy can complement traditional medical treatments and contribute to a more comprehensive treatment plan. TO ACHIEVE A POSITIVE RESULT, DAILY LISTENING TO VIDEOS IS REQUIRED. I wish you health and prosperity!

Holoprosencephaly_Sound therapy session

#resonantfrequencytherapy #Holoprosencephaly #adjunctivetreatment #traditionalmedicine #benefits #braindevelopment #neurologicaldisorder #ho

[imran16829]

Missing British Girl's Dead Body Found: Nora Quoirin Biography, Wiki, Age, Family, Net Worth, Twitter, Instagram, Facebook, Fast Facts You Need to Know

Missing British Girl’s Dead Body Found: Nora Quoirin Biography, Wiki, Age, Family, Net Worth, Twitter, Instagram, Facebook, Fast Facts You Need to Know

Nora Quoirin Biography

Nora Quoirin has a brain defect called holoprosencephaly, she has the limited verbal ability and is not able to write or make and receive the phone call.

Nora Quoirin Age

She was 15 years old.

Nora Quoirin Parents

Nora’s parents, Frenchman Sebastien, 47, and Irish woman Meabh, 45, faced the harrowing ordeal of identifying their daughter’s body in the mortuary today.

Malays…

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