#maraviroc

[mindblowingscience]

HIV Drug Helps Memories Stay Connected With Age, Intriguing Mouse Study Finds

The authors are now organizing a clinical trial to test maraviroc's influence on early memory loss in humans.

A common HIV drug has been shown to improve the connections between memories in aging mice. The findings could help reveal how contextual events are remembered in the human brain, and why this becomes harder as we age.

The HIV drug, known as maraviroc, acts on a cellular protein known as CCR5, which sits on the surface of white blood cells. When the HIV virus connects with one of these receptors, it can enter the cell and replicate. But if maraviroc gets there first, it blocks the entrance.

And that's not all it does. In 2019, researchers working in mouse models found that maraviroc can also help neurons to make new connections following a stroke.

Now, another mouse study has cast more light on the workings of this drug, including its effects on cells involved in memory. When mice naturally age, researchers noticed the expression of CCR5 in the neurons of their hippocampus also increased.

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[pharmaceuticalresearch]

High-Purity Mefloquine Impurities Standards from SynZeal for Reliable Drug Development | SZ-M096001

SynZeal’s Maraviroc impurity standards offer the reliability needed for precision in antiretroviral R&D and regulatory documentation.

[thoughtlessarse]

HIV Medication Could Slow Dementia

The drug clears toxic brain proteins and had positive results in mice.

Maraviroc (Selzentry), an antiretroviral treatment approved for HIV, has also reportedly aided the brain functions caused by dementia in mice, according to a study published in Neuron. Researchers from Cambridge Institute for Medical Research and the UK Dementia Research Institute at the University of Cambridge in England identified that autophagy, the body’s natural way of cleaning out damaged cells, did not work correctly in mice with dementia, including those with Huntington’s disease. Neurodegenerative diseases like Huntington’s and Alzheimer’s can lead to the degradation and death of brain cells after a buildup of toxic proteins in the brain. Although the results from the study were encouraging, Dr. Marc Gordon, chief of neurology at Zucker Hillside Hospital in New York, told Medical News Daily, “It is still very early in the process. Typically, from this point, if all goes well, it could take 12 to 15 years to get to a new drug. However, since researchers used an existing drug, it could be as soon as five to eight years.”

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[projectqueer]

Maraviroc May Need Help as PrEP

Maraviroc has promise but may need to be paired with another medication to be a true alternative to Truvada.

The findings, presented at this year’s Conference on Retroviruses and Opportunistic Infections were less positive than hoped. 

The NEXT-PrEP study, examined the possibility of using the drug Maraviroc as an alternative to Truvada as a method for pre-exposure prophylaxis to prevent HIV. Maraviroc had been considered a particularly viable candidate for PrEP because, it’s a type of drug not commonly used in treating HIV. That uniqueness lowers the chance of someone becoming resistant to the drug; and could make it an alternative for those who’ve developed Truvada-resistance.

An entry inhibitor, Maraviroc prevents HIV infection by attaching itself to the same part of the white blood cells that the virus needs to connect with, thus blocking HIV from attaching and replicating.

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[medphoenix]

Marowak has high defense, so it uses that to defend WBC from HIV by blocking the binding of HIV outer envelope protein gp120 to the CCR5 chemokine receptor on the WBC. 

Maroviroc (Marowak), HIV entry inhibitor 

Only works for CCR5-selective tropic strains of HIV

Pharmacokinetics: CYP3A4 (can be toxic if co-administer with other CYP)

Adverse effects: well-tolerated :)

Resistance: 

Shift in viral tropism (HIV-->AIDS)

Mutations of HIV's gp120 to allow binding of virus in presence of inhibitor

[froggie901]

Research. Research. Research.

Ugh. Time to vent. I'm hoping that writing this makes / help me problem solve of my research issue. So, if it is extra fussy I'm sorry. So what does this pill separation boil down too? - differential solubility - changes in solubility What do I know? - when I crush the pill and dissolve it in MeOH, the major component is maraviroc. (Confirmed via NMR) - The other components are magnesium stearate, cellulose, and other starches. - maraviroc is soluble in methanol, acetonitrile, and DMSO - adding water causes a waxy substance to crash out. - this waxy substance is soluble in MeOH and DCM and insoluble in hexanes - attempts to crash the waxy stuff out of solution in -78 DCM failed - attempted to crash out via -78 hexanes failed too (sadly) ... - TLC: combinations of hexanes, DCM, and methanol (w/ or w/o formic acid) move the compounds. So what does this mean? 1.) extract these gummy bits from the aqueous layer... 2.) run a short silica plug to remove the magnesium stearate 3.) the sugars? Should be pH sensitive... Small concern... - very small amount seemed to extracted from original crushed pill extraction. Original - 207.6 (1/6th of total - thus maximum maraviroc 50mg)