I'll be one to point that out that some sectors of the MCU are better at addressing this than others, usually the ones where it's strongly implied why others wouldn't be involved or a reason is outright given that seems plausible. To give examples:
Iron Man 3: Rhodey explicitly says the US government wants to prove they can handle threats without the Avengers' help (which is a big reason for the Iron Patriot rebranding of War Machine). Meanwhile, Tony is also cut off from his allies when he's stranded in Tennessee for the middle part of the movie, and by the time he links back up with Rhodey, they're in a race against the clock to rescue the President and Pepper.
Captain America: The Winter Soldier had Steve and Natasha branded as fugitives by HYDRA. Sam's the only ally they can scrounge up until they link up with Fury and Maria.
Ant-Man: Hank Pym harbors his grudge against SHIELD for their misuse of Pym Particles.
Doctor Strange had Wong explaining that the Masters of the Mystic Arts deal with all the mystical threats the Avengers don't deal with (with Endgame later retroactively showing the Ancient One defending the New York Sanctum during the Chitauri invasion).
Ant-Man and the Wasp and Endgame established Scott and Clint as being on house arrest as a result of the fallout from Civil War to explain their lack of involvement in Infinity War.
Black Widow justifies the lack of other heroes' involvement (and Natasha and Yelena instead having to team up with their adopted parents) by being set during the immediate fallout from Civil War.
The Netflix shows had the reasons strongly implied: with the Hand, they were a shadow organization. The storylines in each season of Jessica Jones involve cases very personal for Jessica. The Punisher sees Frank's stories happen largely disconnected from the rest of the shows save for the Turk Barrett and Karen Page cameos because the other heroes wouldn't tolerate his use of lethal force on criminals. Daredevil season 3 had Matt in a mentally bad place post-Midland Circle, as well as Fisk using the FBI to tarnish him, Karen, and Foggy.
Honestly I think WandaVision belongs on this list because there's good reasons for the other Avengers to not be involved (the Hex erases' outsiders knowledge of Westview existing, only about a day passed between SWORD determining Wanda was behind the Hex and Wanda taking down the Hex; and Hayward wouldn't want the Avengers poking around when he's in the process of desecrating the corpse of one of their own and framing another for his crimes), though Strange's reasons for not getting involved as mentioned in DSMOM are pushing it.
I mean fair enough there are better explanations then others. When it's stuff like CAWS it's fine to go with idea of we're dealing with the situations as it comes and we don't have the time or the means to call anyone in. With the netflix shows the characters ran in different circles so you don't expect them to be able to call on anyone.
WandaVision is an interesting example because originally Doctor Strange was going to be there. That watch commercial was originally meant to be alluded to him trying to get through to Wanda.
I think it only really becomes a problem when people in-universe ask why can't they call someone and the answer is always just "No, because reason. Shut up." like they never give a good explanation
