#mtorc1

[evolving-science]

The Opposite Of Apoptosis? Research Confirms That Regeneration Does Occur In Adult Cells

For a long time, it was thought mature cells (those that constitute the tissues in living organisms) could not proliferate in order to repair any damage. However, a new study has uncovered the physiological process of paligenosis, the “other side” of apoptosis for injured cells.

[neurosciencenews]

Protein Links Alcohol Abuse and Changes in Brain’s Reward Center

When given access to alcohol, over time mice develop a pattern similar to what we would call “problem drinking” in people, but the brain mechanisms that drive this shift have been unclear. Now a team of UC San Francisco researchers has identified a protein that links alcohol consumption with structural changes in one of the “reward centers” in the mouse brain.

The research is in Neuron. (full access paywall)

[yackni-blog1]

Over the past 10 years, the increase in comprehension of the mechanisms behind acne has been truly exponential. Starting with the ethnological work of Cordain, accelerated by the epidemiological work of Adebamowo, supported by the clinical trials of Smith and Mann, Kwon, DiLandro and others, the interface of diet and acne is coming into focus. Melnik now presents an exceptional pair of papers that illustrate for dermatologists what translational research is all about. The Western diet, the role of dairy, FoxO1 and mTORC1, the interplay of agonists and antagonists, therapeutics present and future - the jigsaw puzzle is coming together.