#oncogenic

[xxredridinghoodxx]

The ongoing pandemic so many of you are ignoring is it's own genocide. Just so you know. Every week, every day, every month -- contracting, spreading, hospitalized, killed, disabled, disabled further -- because of SARS-CoV-2 -- being spread, minimized, lack of concern/care, growing fascism, eugenics, and even claimed to be beneficial to catch and give to others. Also propaganda.

[dr-afsaeed]

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition - Research

Opposing oncogenic and tumor-suppressive forces establish a progenitor-like state that builds a self-reinforcing niche to drive benign-to-malignant transition in pancreatic cancer models. Disruption of p53 activity or KRAS inhibits malignancy by collapsing the niche. Read more about this post… Credits: Source Disclaimer

Oncogenic and tumor-suppressive forces converge on a progenitor niche at the benign-to-malignant transition - Research

[dr-afsaeed]

EcDNA-borne structural variants drive oncogenic fusion transcript amplification - Research

Extrachromosomal DNA (ecDNA) is a major source of oncogenic fusions across cancer types, generating tissue-specific fusion landscapes with diagnostic potential. EcDNA-borne PVT1 5′-end fusions stabilize partner RNAs and boost oncogene output. Read more about this post… Credits: Source Disclaimer

[freehealthteacher]

Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors

Scientists reveal novel oncogenic driver gene in human gastrointestinal stromal tumors

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Sarcomas – cancers that arise from transformed mesenchymal cells (a type of connective tissue) – are quite deadly. Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and are initiated by activating mutations in the KIT receptor tyrosine kinase.

Micro-GISTs are a smaller variation of clinical GISTs and are found in one-third of the general population without…

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[dubjob999]

Postdoctoral Position: Oncogenic Splicing Factors and Cancer Metabolism

http://bit.ly/2GeJ8jc

ETH Zürich Location : Zürich ZH CH Applicants should hold a PhD, MD/PhD or MD degree with a strong background in mouse genetics, handling and analyses, molecular and biology, be highly motivated,…

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The post Postdoctoral Position: Oncogenic Splicing Factors and Cancer Metabolism appeared first on DUBJOB.COM.

[currentsinbiology]

Stress wakes up sleeping herpesviruses -- but how?

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, eventually causing cell death by lysis - the lytic phase. This process allows the virus to multiply and spread usually through lesions of the skin, as in the case of the well known Herpes Simplex virus. Unlike the Herpes Simplex, however, some other herpesviruses can cause cancer, they are oncogenic.

The study, a combination of the most advanced microscopy technologies and genetic manipulation techniques, shows that a variety of chemical stresses all lead to the activation of a set of cellular "stress-sensors" proteins -  like p53 and p21clip - that in the attempt of rescuing the cell from the exogenous stress slow down cell proliferation. This process seems to create an environment that favors the production of viral lytic genes, which few hours after reactivation lead to massive damage of the cellular DNA and arrest the cell division cycle in a stage known as Gap-2 phase or G2. In this status, cells are kept alive by viral proteins and all cellular nutrients and resources are redirected to the assembly of thousands of new virions.

[whatisdictionary]

oncology

Definition of oncology

noun

the scientific study of new growths, especially cancers

oncology was originally published on What Is Dictionary