Two of the published clinical reports of yeast infection say more about human desperation than the tendency of the fungus to cause disease. Both concern instances of self-inflicted Saccharomyces infection. The first, from Columbia, Missouri, in the 1970s, involved a sixty-eight-year-old man with an unusual diet. He was a health food enthusiast who medicated himself with vitamins and, in a vein unrelated to his belief in dietary supplements, drank a full pint of vodka every day. Then he began developing symptoms of influenza and was admitted to a hospital. Nothing in the case history alarmed his physicians until the patient admitted to swallowing massive quantities of brewer’s yeast. The clinical report says that he consumed up to three kilograms of dried yeast per day, which is equivalent to hundreds of the little sachets used in bread-making. There is likely a typo in the transcript. He would have needed much more than a pint of vodka to wash that down. In any case, this gentleman developed fungemia that was misdiagnosed initially as a bacterial infection. His condition improved when he “was instructed to discontinue use of brewer’s yeast.”
The second case is more bizarre. It involved Vietnamese refugees in a Hong Kong detention center who injected themselves with yeast precisely in order to induce infections, and therefore to be admitted a hospital. One of the patients was a teenage boy admitted to hospital with convulsions. The other was a woman suffering from shock who presented with a serious abscess in her breast, presumably at the injection site. Once they were admitted to hospital they absconded. In the column of the table reserved for clinical outcome, the report says, “Seen running away.” One hopes that these victims survived.
Concern about Saccharomyces infections has grown with reports that they are associated with the use of yeast as a probiotic, as was the case with the vodka drinker. Probiotics are microorganisms whose ingestion is thought to bestow health benefits. Probiotic yeast is sold in capsules as a treatment for a wide range of digestive disorders, and as a daily supplement to maintain a healthy bowel function. The capsules contain a freeze-dried preparation of Saccharomyces boulardii, which is probably a strain of Saccharomyces cerevisiae, rather than a separate species. Nonetheless, it behaves quite differently from the strains of the sugar fungus used to brew beer and leaven bread. The association between the use of boulardii as a probiotic and development of yeast infections should not concern the majority of people who have benefited from the probiotic.